Basic Description

Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Monosaccharide derivative of glucose found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. Used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s).
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Canonical SMILES	CC(=O)N[C@@H](C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
Isomeric SMILES	CC(=O)N[C@@H](C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
WGK Germany	3
PubChem CID	1738118
Molecular Weight	221.21
Beilstein	1727589
Reaxy-Rn	1913592

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
I2412091	Certificate of Analysis	Sep 24, 2024	A105212
I2412092	Certificate of Analysis	Sep 24, 2024	A105212
I2412093	Certificate of Analysis	Sep 24, 2024	A105212
E2308212	Certificate of Analysis	May 19, 2023	A105212
E2308215	Certificate of Analysis	May 19, 2023	A105212
E2308307	Certificate of Analysis	May 19, 2023	A105212
H2204254	Certificate of Analysis	Aug 09, 2022	A105212
H2204256	Certificate of Analysis	Aug 09, 2022	A105212
H2204263	Certificate of Analysis	Aug 09, 2022	A105212
K2119058	Certificate of Analysis	Nov 25, 2021	A105212

Chemical and Physical Properties

Specific Rotation[α]	+39.0 to +43.0 deg(C=1, H2O)
Melt Point(°C)	211°C

Safety and Hazards(GHS)

WGK Germany	3
Reaxy-Rn	1913592

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yan Yuandong, Wang Ruyi, Zheng Qian, Zhong Jiaying, Hao Weichang, Yan Shicheng, Zou Zhigang. (2023) Nonredox trivalent nickel catalyzing nucleophilic electrooxidation of organics. Nature Communications, 14 (1): (1-11). [PMID:38042856] [10.1038/s41467-023-43649-6]
2. Huahai Yu, Ying Piao, Yifan Zhang, Jiajia Xiang, Shiqun Shao, Jianbin Tang, Zhuxian Zhou, Youqing Shen. (2023) Cell-Selective Binding Zwitterionic Polymeric Micelles Boost the Delivery Efficiency of Antibiotics. ACS Nano, 17 (22): (22430–22443). [PMID:37933869] [10.1021/acsnano.3c05181]
3. Ai Yuan-li, Wang Wei-jia, Liu Fan-jian, Fang Wei, Chen Hang-zi, Wu Liu-zheng, Hong Xuehui, Zhu Yuekun, Zhang Ci-xiong, Liu Long-yu, Hong Wen-bin, Zhou Bo, Chen Qi-tao, Wu Qiao. (2023) Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. CELL RESEARCH, (1-19). [PMID:37460805] [10.1038/s41422-023-00848-6]
4. Anand Babu Perumal, Reshma B Nambiar, Xuelun Luo, Zhenzhu Su, Xiaoli Li, Yong He. (2023) Exploring dynamic changes of fungal cellular components during nanoemulsion treatment by multivariate microRaman imaging. TALANTA, 261 (124666). [PMID:37210918] [10.1016/j.talanta.2023.124666]
5. Shiwei Liu, Shuang Han, Yuzhuo Song, Ruonan Sun, Le Zhao, Chen Yan. (2023) Disulfide-Bridged Dendritic Organosilicas-Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox-Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy. Advanced Healthcare Materials, 12 (20): (2300184). [PMID:36943098] [10.1002/adhm.202300184]
6. Liu Quanzhen, Wei Guoguang, Yang Pengfan, Wang Chengyong, Chen Kequan, Ouyang Pingkai, Zhang Alei. (2023) One-pot biosynthesis of N-acetylneuraminic acid from chitin via combination of chitin-degrading enzymes, N-acetylglucosamine-2-epimerase, and N-neuraminic acid aldolase. Frontiers in Microbiology, 14 [PMID:37025634] [10.3389/fmicb.2023.1156924]
7. Kai Wang, Yunfei Xiao, Changchun Wu, Yimo Feng, Zhipeng Liu, Xi Zhu, Hongjun Zang. (2023) Direct conversion of chitin derived N-acetyl-D-glucosamine into 3-acetamido-5-acetylfuran in deep eutectic solvents. CARBOHYDRATE RESEARCH, 524 (108742). [PMID:36716693] [10.1016/j.carres.2023.108742]
8. Yan Liang, Ping-Yu Wang, You-Jie Li, Ze-Yun Liu, Ran-Ran Wang, Guang-Bin Sun, Hong-Fang Sun, Shu-Yang Xie. (2023) Multistage O2-producing liposome for MRI-guided synergistic chemodynamic/chemotherapy to reverse cancer multidrug resistance. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 631 (122488). [PMID:36521638] [10.1016/j.ijpharm.2022.122488]
9. Xinjun Yu, Zengchao Jiang, Xiaodan Xu, Changyi Huang, Zheyi Yao, Xiao Yang, Yinjun Zhang, Dongsheng Wang, Chun Wei, Xuwei Zhuang. (2022) Mechano-Enzymatic Degradation of the Chitin from Crustacea Shells for Efficient Production of N-acetylglucosamine (GlcNAc). MOLECULES, 27 (15): (4720). [PMID:35897896] [10.3390/molecules27154720]
10. Han Xu, Ninghua Fu, Jie Zheng, Muhammad Sohail, Xing Zhang. (2022) Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives. BIOORGANIC CHEMISTRY, 128 (106041). [PMID:35907378] [10.1016/j.bioorg.2022.106041]
11. Chaoqiang Wu, Chengyong Wang, Alei Zhang, Kequan Chen, Fei Cao, Pingkai Ouyang. (2022) Preparation of 3-aceta mido-5-acetylfuran from N-acetylglucosamine and chitin using biobased deep eutectic solvents as catalysts. Reaction Chemistry & Engineering, 7 (8): (1742-1749). [PMID:] [10.1039/D2RE00118G]
12. Lei Li, Yun Fang, Yongmei Xia, Chunling Bo, Ye Fan. (2022) Monosaccharides driving the formation of conjugated linoleic acid vesicles in near-neutral solutions via weak noncovalent bonding interactions. JOURNAL OF MOLECULAR LIQUIDS, 351 (118656). [PMID:] [10.1016/j.molliq.2022.118656]
13. Kequan Chen, Chaoqiang Wu, Chengyong Wang, Alei Zhang, Fei Cao, Pingkai Ouyang. (2021) Chemo-enzymatic protocol converts chitin into a nitrogen-containing furan derivative, 3-acetamido-5-acetylfuran. Molecular Catalysis, 516 (112001). [PMID:] [10.1016/j.mcat.2021.112001]
14. Shuo Shi, Guocheng Wang, Jie Liu, Sunan Liu, Qiuyu Xu, Xi Lan, Jianxing Feng, Jing Sun, Wentao Zhang, Jianlong Wang. (2021) Gentiana straminea Maxim. polysaccharide decolored via high-throughput graphene-based column and its anti-inflammatory activity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 193 (1727). [PMID:34774595] [10.1016/j.ijbiomac.2021.11.010]
15. Guangyao Huang, Hongxin Zhao, Pan Li, Juanjuan Liu, Siyu Chen, Meihong Ge, Miao Qin, Guoliang Zhou, Yongtao Wang, Shaofei Li, Yizhuang Cheng, Qiang Huang, Junfeng Wang, Hongzhi Wang, Liangbao Yang. (2021) Construction of Optimal SERS Hotspots Based on Capturing the Spike Receptor-Binding Domain (RBD) of SARS-CoV-2 for Highly Sensitive and Specific Detection by a Fish Model. ANALYTICAL CHEMISTRY, 93 (48): (16086–16095). [PMID:34730332] [10.1021/acs.analchem.1c03807]
16. Xiaoguo Ji, Liangliang Zhu, Kunlin Chang, Ran Zhang, Yijia Chen, Hao Yin, Jiayang Jin, Liming Zhao. (2022) Chitooligosaccahrides: Digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro. CARBOHYDRATE POLYMERS, 275 (118716). [PMID:34742440] [10.1016/j.carbpol.2021.118716]
17. Ning Zhou, Pengfan Yang, Jie Chen, Guoguang Wei, Chengyong Wang, Alei Zhang, Kequan Chen, Pingkai Ouyang. (2022) Effect of organic solvents treatment on structure of chitin and its enzymatic hydrolysis. POLYMER DEGRADATION AND STABILITY, 198 (109654). [PMID:] [10.1016/j.polymdegradstab.2021.109654]
18. Meng Wensi, Zhang Lijie, Cao Menghao, Zhang Yongjia, Zhang Yipeng, Li Ping, Kang Zhaoqi, Guo Shiting, Xu Ping, Ma Cuiqing, Gao Chao. (2021) 2,3-Butanediol synthesis from glucose supplies NADH for elimination of toxic acetate produced during overflow metabolism. Cell Discovery, 7 (1): (1-12). [PMID:34103474] [10.1038/s41421-021-00273-2]
19. Alei Zhang, Chengyong Wang, Jie Chen, Guoguang Wei, Ning Zhou, Ganlu Li, Kequan Chen, Pingkai Ouyang. (2021) Efficient enzymatic hydrolysis of chitin into N-acetyl glucosamine using alkali as a recyclable pretreatment reagent. GREEN CHEMISTRY, 23 (8): (3081-3089). [PMID:] [10.1039/D1GC00818H]
20. Hongjun Zang, Jing Lou, Shuolei Jiao, Huanxin Li, Yannan Du, Jiao Wang. (2021) Valorization of chitin derived N-acetyl-D-glucosamine into high valuable N-containing 3-acetamido-5-acetylfuran using pyridinium-based ionic liquids. JOURNAL OF MOLECULAR LIQUIDS, 330 (115667). [PMID:] [10.1016/j.molliq.2021.115667]
21. Xiaomei Li, Xiaoman Li, Jing Zhu, Haoxin Wang, Chunhua Lu. (2020) Carbamothioic S-acid derivative and kigamicins, the activated production of silent metabolites in Amycolatopsis alba DSM 44262Δabm9 elicited by N-acetyl-D-glucosamine. NATURAL PRODUCT RESEARCH, [PMID:30784305] [10.1080/14786419.2019.1574783]
22. Yue Sun, Shi-Qi Cheng, Junkai Ma, Fei Zhu, Wei Hong, Haibing Li. (2020) Biomimetic nanochannels platform for detecting N-acetylglucosamine analogues. SENSORS AND ACTUATORS B-CHEMICAL, 323 (128705). [PMID:] [10.1016/j.snb.2020.128705]
23. Cheng R., Wang L., Li J., Fu R., Wang S., Zhang J.. (2019) In vitro and in vivo anti‐inflammatory activity of a succinoglycan Riclin from Agrobacterium sp. ZCC3656. JOURNAL OF APPLIED MICROBIOLOGY, 127 (6): (1716-1726). [PMID:31517429] [10.1111/jam.14447]
24. Yu Yu, Li Kecheng. (2020) Adsorption characteristics of chitooligosaccharides onto activated charcoal in aqueous solutions. Journal of Oceanology and Limnology, 38 (2): (342-350). [PMID:] [10.1007/s00343-019-8327-2]
25. Fusheng Zhang, Dongdong Wang, Haijuan Qin, Liang Feng, Xinmiao Liang, Guangyan Qing. (2019) Chemoselectivity of Pristine Cellulose Nanocrystal Films Driven by Carbohydrate–Carbohydrate Interactions. ACS Applied Materials & Interfaces, 11 (14): (13114–13122). [PMID:30880380] [10.1021/acsami.9b00471]
26. Kecheng Li, Andrew R. Green, Meredith M. Dinges, Cynthia K. Larive. (2019) 1H NMR characterization of chitin tetrasaccharide in binary H2O:DMSO solution: Evidence for anomeric end-effect propagation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 129 (744). [PMID:30771389] [10.1016/j.ijbiomac.2019.02.062]
27. Qiu Xiuzhen, Xu Xian-Yan, Chen Xuncai, Wu Yiyong, Guo Huishi. (2018) Preparation of a molecularly imprinted sensor based on quartz crystal microbalance for specific recognition of sialic acid in human urine. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (18): (4387-4395). [PMID:29736700] [10.1007/s00216-018-1094-7]
28. Mou Tang, Wenting Zhou, Yi Liu, Jiabao Yan, Zhiwei Gong. (2018) A two-stage process facilitating microbial lipid production from N-acetylglucosamine by Cryptococcus curvatus cultured under non-sterile conditions. BIORESOURCE TECHNOLOGY, 258 (255). [PMID:29533885] [10.1016/j.biortech.2018.03.015]
29. Yunrui Zhang, Haihong Niu, Xiangjie Zhang, Junxiu Pan, Yang Dong, Haijun Wang, Yongjun Gao. (2017) Magnetic N-containing carbon spheres derived from sustainable chitin for the selective oxidation of C–H bonds. RSC Advances, 7 (82): (51831-51837). [PMID:] [10.1039/C7RA10226G]
30. Guoguang Wei, Alei Zhang, Kequan Chen, Pingkai Ouyang. (2017) Enzymatic production of N-acetyl-d-glucosamine from crayfish shell wastes pretreated via high pressure homogenization. CARBOHYDRATE POLYMERS, 171 (236). [PMID:28578959] [10.1016/j.carbpol.2017.05.028]
31. Yan Liang, Baocheng Tian, Jing Zhang, Keke Li, Lele Wang, Jingtian Han, Zimei Wu. (2017) Tumor-targeted polymeric nanostructured lipid carriers with precise ratiometric control over dual-drug loading for combination therapy in non-small-cell lung cancer. International Journal of Nanomedicine, [PMID:28280336] [10.2147/IJN.S121262]
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33. Shan-Wei Li, Raymond J. Zeng, Guo-Ping Sheng. (2017) An excellent anaerobic respiration mode for chitin degradation by Shewanella oneidensis MR-1 in microbial fuel cells. BIOCHEMICAL ENGINEERING JOURNAL, 118 (20). [PMID:] [10.1016/j.bej.2016.11.010]
34. Cong Gao, Alei Zhang, Kequan Chen, Zhikui Hao, Junmao Tong, Pingkai Ouyang. (2015) Characterization of extracellular chitinase from Chitinibacter sp. GC72 and its application in GlcNAc production from crayfish shell enzymatic degradation. BIOCHEMICAL ENGINEERING JOURNAL, 97 (59). [PMID:] [10.1016/j.bej.2015.02.010]
35. Baocheng Tian,Yuanyuan Ding,Jian Han,Jing Zhang,Yuzhen Han,Jingtian Han. (2015-04-30) N-Acetyl-D-glucosamine decorated polymeric nanoparticles for targeted delivery of doxorubicin: Synthesis, characterization and in vitro evaluation.. Colloids and surfaces. B, Biointerfaces, 130 (246-254). [PMID:25921641]
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References

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N-Acetyl-D-glucosamine - 97%, high purity , CAS No.7512-17-6