Skip to the beginning of the images gallery

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate - 98%, high purity , CAS No.53678-77-6, Agonist of NLRP1;Agonist of nucleotide binding oligomerization domain containing 2

Moligand™

≥98%

CAS#: 53678-77-6
Formula: C₁₉H₃₂N₄O₁₁·xH₂O
Molecular Weight: 492.48 (anhydrous basis)
MDL number: MFCD00077638
PubChem CID: 11620162

Item Number

N303924

Grouped product items
SKU	Size	Availability	Price	Qty
N303924-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
N303924-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$349.90

Activates NOD2 receptors

View related series

Immunology/Inflammation MAPK/ERK Pathway NLRP1 Agonist NOD-like Receptor (NLR) nucleotide binding oligomerization domain containing 2 Agonist p38 MAPK

Basic Description

Synonyms	Adjuvant Peptide \| s9709 \| Q259464 \| AKOS034831580 \| N-Acetylmuramoyl-L-alanyl-D-?-glutamine \| (4R)-4-carbamoyl-4-[(2S)-2-[(2R)-2-{[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}propanamido]propanamido]butanoic acid \| BDBM50505203
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Bacterial peptidoglycan fragment that activates NOD2 receptors. Induces polarization of proinflammatory Ly6Chighinto Ly6Clowpatrolling monocytes.Enhance the antigenicity of weak antigens, thereby increasing antibody titers. N-acetylmuramyl-L-alanyl-D-isog
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of NLRP1;Agonist of nucleotide binding oligomerization domain containing 2

Associated Targets(Human)

NOD2 Tclin Nucleotide-binding oligomerization domain-containing protein 2 (1 Activities)

Discover Target: NOD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NLRP1 Tbio NACHT, LRR and PYD domains-containing protein 1 (0 Activities)

Discover Target: NLRP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOD1 Tchem Nucleotide-binding oligomerization domain-containing protein 1 (1322 Activities)

Discover Target: NOD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NOD2 Tclin Nucleotide-binding oligomerization domain-containing protein 2 (1613 Activities)

Discover Target: NOD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NLRP3 Tchem NACHT, LRR and PYD domains-containing protein 3 (908 Activities)

Discover Target: NLRP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Oryctolagus cuniculus (11301 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(4R)-4-[[(2S)-2-[[(2R)-2-[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid
INCHI	InChI=1S/C19H32N4O11/c1-7(17(30)23-10(16(20)29)4-5-12(26)27)21-18(31)8(2)33-15-13(22-9(3)25)19(32)34-11(6-24)14(15)28/h7-8,10-11,13-15,19,24,28,32H,4-6H2,1-3H3,(H2,20,29)(H,21,31)(H,22,25)(H,23,30)(H,26,27)/t7-,8+,10+,11+,13+,14+,15+,19?/m0/s1
InChi Key	BSOQXXWZTUDTEL-QAQREVAFSA-N
Canonical SMILES	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C
Isomeric SMILES	C[C@@H](C(=O)N[C@H](CCC(=O)O)C(=O)N)NC(=O)[C@@H](C)O[C@H]1[C@@H]([C@H](OC([C@@H]1NC(=O)C)O)CO)O
PubChem CID	11620162
Molecular Weight	492.48 (anhydrous basis)

Wikipedia

ChEBI

CAS Registry No.

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
H2316667	Certificate of Analysis	Jul 21, 2023	N303924
H2316668	Certificate of Analysis	Jul 21, 2023	N303924
L2315337	Certificate of Analysis	Jul 21, 2023	N303924
L2315338	Certificate of Analysis	Jul 21, 2023	N303924

Solubility

Solvent:water, Max Conc. mg/mL: 49.25, Max Conc. mM: 100

Boil Point(°C)

1071.8±65.0 °C(Predicted)

References

1. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M et al.. (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.. J Biol Chem, 278 (8): (5509-12). [PMID:12514169] [10.1021/op500134e]
2. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.. J Biol Chem, 278 (11): (8869-72). [PMID:12527755] [10.1021/op500134e]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate - 98%, high purity , CAS No.53678-77-6, Agonist of NLRP1;Agonist of nucleotide binding oligomerization domain containing 2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator