N-Acetylneuraminic acid - 98%, high purity , CAS No.131-48-6

  • ≥98%
Item Number
A100555
Grouped product items
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A100555-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$122.90
A100555-250mg
250mg
In stock
$148.90
A100555-1g
1g
In stock
$172.90
A100555-5g
5g
In stock
$778.90
A100555-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,401.90
A100555-25g
25g
In stock
$3,152.90
A100555-100g
100g
In stock
$11,350.90

Basic Description

SynonymsNAN | NANA | b-5-acetamido-3,5-dideoxy-D-glycero-D-galacto-Nonulopyranosonate | N-Acetyl-b-neuraminate | N-Acetylsialic acid | A-1600 | CHEBI:45744 | EN300-174088 | N-acetylneuramic acid | SMR000857174 | N-Acetyl-delta-neuraminic acid | 4mnp | (2S,4S,5R,6
Specifications & Purity≥98%
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads

Associated Targets(Human)

NEU2 Tbio Sialidase 2 (382 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NEU3 Tchem Sialidase 3 (398 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NEU4 Tchem Sialidase 4 (267 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NEU1 Tchem Sialidase 1 (236 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488189832
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189832
IUPAC Name (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
INCHI InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1
InChi Key SQVRNKJHWKZAKO-PFQGKNLYSA-N
Canonical SMILES CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
Isomeric SMILES CC(=O)N[C@@H]1[C@H](C[C@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)O)O
WGK Germany 3
PubChem CID 445063
Molecular Weight 309.27
Beilstein 1716283
Reaxy-Rn 1716283

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

29 results found

Lot NumberCertificate TypeDateItem
L2407020Certificate of AnalysisNov 15, 2024 A100555
K2428222Certificate of AnalysisNov 15, 2024 A100555
K2428221Certificate of AnalysisNov 15, 2024 A100555
K2428219Certificate of AnalysisNov 15, 2024 A100555
K2428218Certificate of AnalysisNov 15, 2024 A100555
I2022150Certificate of AnalysisJul 10, 2024 A100555
I2406032Certificate of AnalysisAug 29, 2022 A100555
J2422022Certificate of AnalysisAug 29, 2022 A100555
J2313100Certificate of AnalysisAug 29, 2022 A100555
J2210133Certificate of AnalysisAug 29, 2022 A100555
J2210132Certificate of AnalysisAug 29, 2022 A100555
J2210131Certificate of AnalysisAug 29, 2022 A100555
J2210125Certificate of AnalysisAug 29, 2022 A100555
J2210107Certificate of AnalysisAug 29, 2022 A100555
J2210105Certificate of AnalysisAug 29, 2022 A100555
G2402068Certificate of AnalysisAug 29, 2022 A100555
F2314414Certificate of AnalysisAug 29, 2022 A100555
B2420042Certificate of AnalysisAug 29, 2022 A100555
B2321083Certificate of AnalysisAug 29, 2022 A100555
B2219235Certificate of AnalysisJan 07, 2022 A100555
G2306099Certificate of AnalysisJan 07, 2022 A100555
D2310234Certificate of AnalysisJan 07, 2022 A100555
B2321105Certificate of AnalysisJan 07, 2022 A100555
J2326136Certificate of AnalysisJan 07, 2022 A100555
B2321084Certificate of AnalysisJan 07, 2022 A100555
B2321068Certificate of AnalysisJan 07, 2022 A100555
B2219241Certificate of AnalysisJan 07, 2022 A100555
B2219240Certificate of AnalysisJan 07, 2022 A100555
B2219238Certificate of AnalysisJan 07, 2022 A100555

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Chemical and Physical Properties

SolubilitySoluble in water (50 mg/ml).
SensitivityMoisture &air & heat sensitive
Specific Rotation[α]-32 ° (C=1, H2O)
Melt Point(°C)192-194°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

WGK Germany 3
Reaxy-Rn 1716283
Merck Index 8484

Related Documents

Citations of This Product

1. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du.  (2023)  Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy.  Small,    (15): (2306905).  [PMID:37880861]
2. Guan Hanxiao, Xie Chen, Cao Yuqi, Huang Pingjie, Hou Dibo, Zhang Guangxin.  (2023)  Qualitative Identification of Sialic Acid Content Based on Terahertz Time-Domain Spectroscopy.  Journal of Infrared Millimeter and Terahertz Waves,  44  (9): (780-794).  [PMID:18997780]
3. Li Huixin, Xu Yanpeng, Wang Yang, Cui Yihao, Lin Jiake, Zhou Yuemin, Tang Shuling, Zhang Ying, Hao Haibin, Nie Zihao, Wang Xiaoyu, Tang Ruikang.  (2023)  Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses.  Nature Communications,  14  (1): (1-13).  [PMID:37537158]
4. Shiwei Liu, Shuang Han, Yuzhuo Song, Ruonan Sun, Le Zhao, Chen Yan.  (2023)  Disulfide-Bridged Dendritic Organosilicas-Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox-Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy.  Advanced Healthcare Materials,  12  (20): (2300184).  [PMID:36943098]
5. Liu Quanzhen, Wei Guoguang, Yang Pengfan, Wang Chengyong, Chen Kequan, Ouyang Pingkai, Zhang Alei.  (2023)  One-pot biosynthesis of N-acetylneuraminic acid from chitin via combination of chitin-degrading enzymes, N-acetylglucosamine-2-epimerase, and N-neuraminic acid aldolase.  Frontiers in Microbiology,  14    [PMID:37025634]
6. Huihui Yang, Xiaosen Bai, Baolong Feng, Qinghua Wang, Li Meng, Fengzhong Wang, Yutang Wang.  (2023)  Application of Molecular Transformer approach for predicting the potential reactions to generate advanced glycation end products in infant formula.  FOOD CHEMISTRY,  407  (135143).  [PMID:36516683]
7. Rufeng Zhu, Yuedan Wang, Yang Tao, Yao Wang, Yuanli Chen, Mufang Li, Qiongzhen Liu, Liyan Yang, Dong Wang.  (2022)  Layer-by-layer assembly of composite conductive fiber-based organic electrochemical transistor for highly sensitive detection of sialic acid.  ELECTROCHIMICA ACTA,  425  (140716).  [PMID:]
8. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen.  (2022)  N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  211  (259).  [PMID:35513096]
9. Shuang Han, Yuzhuo Song, Shiwei Liu, Le Zhao, Ruonan Sun.  (2022)  Dual responsive molecularly imprinted polymers based on UiO-66-DOX for selective targeting tumor cells and controlled drug release.  EUROPEAN POLYMER JOURNAL,  171  (111219).  [PMID:]
10. Zeng Jiaxin, Meng Yuan, Chen Shi-Yi, Zhao Gaofeng, Wang Lianchun, Zhang En-Xin, Qiu Hong.  (2022)  Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin.  GLYCOCONJUGATE JOURNAL,  39  (3): (315-325).  [PMID:34699015]
11. Zhang Xin, Wang Chen, Han Qing, Chen Xuan, Li Guoyun, Yu Guangli.  (2021)  Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation.  GLYCOCONJUGATE JOURNAL,  38  (5): (527-537).  [PMID:34480673]
12. Xi Lin, Chunsheng Xiao, Ling Ling, Liming Guo, Xinhua Guo.  (2021)  A dual-mode reactive matrix for sensitive and quantitative analysis of carbohydrates by MALDI-TOF MS.  TALANTA,  235  (122792).  [PMID:34517650]
13. Junyang Chen, Shan Jiang, Mengke Wang, Xiaolei Xie, Xingguang Su.  (2021)  Self-assembled dual-emissive nanoprobe with metal−organic frameworks as scaffolds for enhanced ascorbic acid and ascorbate oxidase sensing.  SENSORS AND ACTUATORS B-CHEMICAL,  339  (129910).  [PMID:]
14. Fan Kai, Lu Chengying, Shu Gaofeng, Lv Xiu-Ling, Qiao Enqi, Zhang Nannan, Chen Minjiang, Song Jingjing, Wu Fazong, Zhao Zhongwei, Xu Xiaoling, Xu Min, Chen Chunmiao, Yang Weibin, Sun Jihong, Du Yongzhong, Ji Jiansong.  (2021)  Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-17).  [PMID:33731140]
15. Feiyang Jin, Jing Qi, Minxia Zhu, Di Liu, Yuchan You, Gaofeng Shu, Yan Du, Jun Wang, Hui Yu, Mingchen Sun, Xiaoling Xu, Qiying Shen, Xiaoying Ying, Jiansong Ji, Yongzhong Du.  (2020)  NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.  ACS Applied Materials & Interfaces,  12  (29): (32372–32387).  [PMID:32597641]
16. Nian Cao, Faqiong Zhao, Baizhao Zeng.  (2020)  A novel ratiometric molecularly imprinted electrochemiluminescence sensor for sensitive and selective detection of sialic acid based on PEI-CdS quantum dots as anodic coreactant and cathodic luminophore.  SENSORS AND ACTUATORS B-CHEMICAL,  313  (128042).  [PMID:]
17. Jinmin Wang, Limin Zhao, Bing Yan.  (2020)  Indicator Displacement Assay Inside Dye-Functionalized Covalent Organic Frameworks for Ultrasensitive Monitoring of Sialic Acid, an Ovarian Cancer Biomarker.  ACS Applied Materials & Interfaces,  12  (11): (12990–12997).  [PMID:32106673]
18. Xiang-Nan He, Ya-Ning Wang, Yue Wang, Zhang-Run Xu.  (2020)  Accurate quantitative detection of cell surface sialic acids with a background-free SERS probe.  TALANTA,  209  (120579).  [PMID:31892066]
19. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji.  (2019)  Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles.  BIOMATERIALS,  217  (119326).  [PMID:31288173]
20. Shaomei Xu, Songtian Che, Pinyi Ma, Fangmei Zhang, Longbin Xu, Xin Liu, Xinghua Wang, Daqian Song, Ying Sun.  (2019)  One-step fabrication of boronic-acid-functionalized carbon dots for the detection of sialic acid.  TALANTA,  197  (548).  [PMID:30771974]
21. Feiyang Jin, Di Liu, Hui Yu, Jing Qi, Yuchan You, Xiaoling Xu, Xuqi Kang, Xiaojuan Wang, Kongjun Lu, Xiaoying Ying, Jian You, Yongzhong Du, Jiansong Ji.  (2019)  Sialic Acid-Functionalized PEG–PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy.  MOLECULAR PHARMACEUTICS,  16  (1): (71–85).  [PMID:30431285]
22. Jing-Bo Hu, Di Liu, Jing Qi, Kong-jun Lu, Fei-yang Jin, Xiao-Ying Ying, Jian You, Yong-Zhong Du.  (2018)  An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury.  Biomaterials Science,  (12): (3397-3409).  [PMID:30371703]
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25. Tiantian Yin, Licong Yang, Yanan Liu, Xianbo Zhou, Jing Sun, Jie Liu.  (2015)  Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease.  Acta Biomaterialia,  25  (172).  [PMID:26143603]
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Solution Calculators