Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A275341-5mg | 5mg | In stock | $51.90 | |
A275341-25mg | 25mg | In stock | $243.90 | |
A275341-100mg | 100mg | In stock | $874.90 |
T-type Ca 2+ channel blocker. Endogenous GLYT2 inhibitor.
Synonyms | LP00074 | NAGly | NA-Gly | HMS1989I06 | N-((5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraen-1-yl)glycine | N-arachidonoyl glycine | NCGC00015042-11 | SDCCGSBI-0050062.P002 | NCGC00093582-04 | HMS3649B11 | NCGC00015042-08 | J-011429 | arachidonoylglycine | NC |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Endogenous inhibitor of GLYT2 with little or no effect on GLYT1 and is analgesic in rat models of neuropathic and inflammatory pain. Anandamide-like compound, with little affinity at CB 1 receptors, VR1 receptors and anandamide transporters. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of GPR18;Agonist of LPA 5 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Describtion: N-arachidonoylglycine (NAgly) is an endogenous ligand and a signaling lipid. It belongs to the eicosanoid family.NAgly is a natural ligand to activate G-protein coupled receptor, namely GPR18.It is found in rat brain and spinal cord.
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IUPAC Name | 2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]acetic acid |
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INCHI | InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15- |
InChi Key | YLEARPUNMCCKMP-DOFZRALJSA-N |
Canonical SMILES | CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCC(=O)O |
Isomeric SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O |
PubChem CID | 5283389 |
Molecular Weight | 361.52 |
PubChem CID | 5283389 |
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ChEBI | CHEBI:58961 |
ChEMBL Ligand | CHEMBL161343 |
CAS Registry No. | 179113-91-8 |
GPCRdb Ligand | N-arachidonoylglycine |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2309054 | Certificate of Analysis | Aug 26, 2024 | A275341 |
K2309062 | Certificate of Analysis | Aug 26, 2024 | A275341 |
K2309138 | Certificate of Analysis | Aug 26, 2024 | A275341 |
K2309140 | Certificate of Analysis | Aug 14, 2024 | A275341 |
K2309141 | Certificate of Analysis | Aug 14, 2024 | A275341 |
K2309195 | Certificate of Analysis | Aug 14, 2024 | A275341 |
Solubility | Soluble in ethanol to 100 mM |
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1. Wang S et al.. (2022) Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc?RIIB and virus-antibody complex with bivalent interaction.. Commun Biol, 5 (262). [PMID:35332252] |