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N-Deacetylcolchicine - ≥97%, high purity , CAS No.3476-50-4
Basic Description Synonyms N-Desacetylcolchicine | (7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one | BRN 2822162 | J-019744 | N-Deacetylcolchicine | Tmca methyl ether | Trimethylcolchicinic acid methyl ether | UNII-2IAP3WIO1P | Benzo(a)heptalen-9(5H)-one, 7 Specifications & Purity ≥97% Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Product Description Antimitotic agent that intercepts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one INCHI InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1 InChi Key HFPMXDMZJUJZBX-AWEZNQCLSA-N Canonical SMILES COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)N Isomeric SMILES COC1=CC=C2C(=CC1=O)[C@H](CCC3=CC(=C(C(=C32)OC)OC)OC)N PubChem CID 18991 Molecular Weight 357.4
Chemical and Physical Properties Solubility Soluble in chloroform, dichloromethane, DMSO, methanol, and water (6.54 g/l). Refractive Index n20D1.60 (Predicted) Boil Point(°C) ~626.6° C at 760 mmHg (Predicted) Melt Point(°C) 80-85° C
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