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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N347521-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $96.90 | |
N347521-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $148.90 | |
N347521-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $285.90 |
Synonyms | N-Deacetylcolchicine|3476-50-4|Deacetylcolchicine|Desacetylcolchicine|(S)-N-Deacetyl Colchicine|N-Desacetylcolchicine|Trimethylcolchicinic acid methyl ether|(S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one|Tmca methyl ether|2IAP3WIO |
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Specifications & Purity | ≥97% |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Product Description | Antimitotic agent that intercepts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal. |
pKa | pKₐ: 8.62 (Predicted) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one |
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INCHI | InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1 |
InChi Key | HFPMXDMZJUJZBX-AWEZNQCLSA-N |
Canonical SMILES | COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)N |
Isomeric SMILES | COC1=CC=C2C(=CC1=O)[C@H](CCC3=CC(=C(C(=C32)OC)OC)OC)N |
PubChem CID | 18991 |
Molecular Weight | 357.4 |
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Solubility | Soluble in chloroform, dichloromethane, DMSO, methanol, and water (6.54 g/l). |
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Refractive Index | n20D1.60 (Predicted) |
Boil Point(°C) | ~626.6° C at 760 mmHg (Predicted) |
Melt Point(°C) | 80-85° C |