N-desmethylclozapine - ≥95%, high purity , CAS No.6104-71-8, Allosteric modulator of M 1 receptor

Item Number

N298816

• Synonyms: N-Desmethylclozapine|Norclozapine|6104-71-8|Desmethylclozapine|Normethylclozapine|N-desmethyl clozapine|Demethylclozapine|NDMC|N-desmethyl-clozapine|8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine|N-DEMETHYLCLOZAPINE|CHEMBL845|8-chloro-11-(piper
• Specifications & Purity: Moligand™, ≥95%
• Biochemical and Physiological Mechanisms: Major metabolite of clozapine; potent 5-HT2 serotonin receptor antagonist and a ligand for the cloned 5-HT6 and 5-HT7 serotonin receptors. Also an allosteric potentiator of M1 muscarinic receptors.Brain penetrant metabolite of the atypical antipsychotic c
• Shipped In: Normal
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of M 1 receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

N-Desmethylclozapine (NDMC), a major metabolite of clozapine , has been found to act as an antagonist of phosphoinositide hydrolysis stimulated by serotonin receptors. NDMC has been shown to be a potent antagonist of SR-2C (aka: 5HT2C), and has been reported to act as a moderate agonist of the rat native and human recombinant mAChR M1(CHRM1). N-Desmethylclozapine is an activator of D2DR and D3DR.
A metabolite of clozapine and neurotransmitter