Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Basic Description
| Synonyms | NEM | maleic acid N-ethylimide | NSC92547 | NSC-92547 | USAF B-121 | ethylmaleimide | HSCI1_000382 | N-ethylmaleimide | 1-Ethyl-1H-pyrrole-2,5-dione | EU-0100492 | GTPL5335 | N-Ethylmaleimide, purum p.a., >=99.0% (HPLC) | MFCD00005509 | NCGC00015415-04 | |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Grade | Moligand™ |
| Product Description | Reagent for the covalent modification of cysteine residues in proteins. Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases. |
Associated Targets(Human)
TYMS Tclin Thymidylate synthase (1651 Activities)
MAOB Tclin Monoamine oxidase B (8835 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLC6A3 Tclin Dopamine transporter (10535 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALB Tchem Serum albumin (2651 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MCF7 (126967 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HEK293 (82097 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
NCI-H460 (60772 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SF-268 (49410 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MGLL Tchem Monoglyceride lipase (1909 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
LMNA Tbio Prelamin-A/C (36751 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
BLM Tchem Bloom syndrome protein (4248 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
THPO Tbio Thrombopoietin (834 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
GMNN Tbio Geminin (128009 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
IDE Tchem Insulin-degrading enzyme (806 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ATG4B Tchem Cysteine protease ATG4B (985 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ANXA2 Tbio Annexin A2 (15 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SENP1 Tchem Sentrin-specific protease 1 (681 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SENP2 Tchem Sentrin-specific protease 2 (79 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MEST Tbio Mesoderm-specific transcript homolog protein (25 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Faah Anandamide amidohydrolase (3907 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Nannizzia gypsea (2039 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Staphylococcus aureus (210822 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Aspergillus flavus (8875 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Aspergillus niger (16508 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Saccharomyces cerevisiae (19171 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Aspergillus fumigatus (16427 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Plasmodium falciparum (966862 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Cryptococcus neoformans (21258 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Candida albicans (78123 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Candida tropicalis (8381 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Trichophyton rubrum (3646 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mus musculus (284745 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Npsr1 Neuropeptide S receptor (260 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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pfk 6-phospho-1-fructokinase (7870 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Trichophyton mentagrophytes (4846 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mapt Microtubule-associated protein tau (6 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mboat4 Ghrelin O-acyltransferase (37 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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crtY Lycopene cyclase (9 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 488179828 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179828 |
| IUPAC Name | 1-ethylpyrrole-2,5-dione |
| INCHI | InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3 |
| InChi Key | HDFGOPSGAURCEO-UHFFFAOYSA-N |
| Canonical SMILES | CCN1C(=O)C=CC1=O |
| Isomeric SMILES | CCN1C(=O)C=CC1=O |
| WGK Germany | 3 |
| RTECS | UX9625000 |
| Alternate CAS | 25668-22-8,128-53-0,25668-22-8 |
| PubChem CID | 4362 |
| NSC Number | 7638 |
| UN Number | 2928 |
| MeSH Entry Terms | Ethylmaleimide;N Ethylmaleimide;N-Ethylmaleimide |
| Molecular Weight | 125.13 |
| Beilstein | 112448 |
| Reaxy-Rn | 112448 |
Database links
| PubChem SID | 488179828 |
|---|
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2402051 | Certificate of Analysis | Jul 05, 2024 | E100552 |
| L2402219 | Certificate of Analysis | Apr 25, 2024 | E100552 |
| D2412071 | Certificate of Analysis | Apr 20, 2024 | E100552 |
| K2110379 | Certificate of Analysis | Aug 02, 2023 | E100552 |
| K2110378 | Certificate of Analysis | May 17, 2023 | E100552 |
| C2303489 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| I2405073 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303600 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303599 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303500 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303499 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303496 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303495 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| C2303490 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| A2426035 | Certificate of Analysis | Mar 09, 2023 | E100552 |
| F2214548 | Certificate of Analysis | Jun 20, 2022 | E100552 |
| F2214549 | Certificate of Analysis | Jun 20, 2022 | E100552 |
| F2214550 | Certificate of Analysis | Jun 20, 2022 | E100552 |
| F2202027 | Certificate of Analysis | Jun 16, 2022 | E100552 |
| F2204274 | Certificate of Analysis | Jun 16, 2022 | E100552 |
| F1828014 | Certificate of Analysis | Feb 22, 2022 | E100552 |
| F2214547 | Certificate of Analysis | Nov 17, 2021 | E100552 |
| K2110380 | Certificate of Analysis | Nov 17, 2021 | E100552 |
Show more⌵
Chemical and Physical Properties
| Solubility | Soluble in water |
|---|---|
| Sensitivity | Light Sensitive |
| Flash Point(°F) | 73 °C |
| Flash Point(°C) | 73°C |
| Boil Point(°C) | 210°C |
| Melt Point(°C) | 43-46°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS06, GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H314:Causes severe skin burns and eye damage H317:May cause an allergic skin reaction H300:Fatal if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |
| WGK Germany | 3 |
| RTECS | UX9625000 |
| Reaxy-Rn | 112448 |
| Merck Index | 3822 |
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| 31. Jiapei Gu, Xiangqian Li, Zhan Zhou, Wanqiang Liu, Kai Li, Jinwei Gao, Ying Zhao, Qianming Wang. (2019) 2D MnO2 nanosheets generated signal transduction with 0D carbon quantum dots: synthesis strategy, dual-mode behavior and glucose detection. Nanoscale, 11 (27): (13058-13068). [PMID:31265041] [10.1039/C9NR03583D] |
| 32. Qing He, Ruixi Li, Zhenwei Yuan, Habtamu Kassaye, Jinrong Zheng, Chen Wei, Fei Wang, Yuxin Yao, Lijuan Gui, Haiyan Chen. (2019) A turn-on near-infrared fluorescent probe for detection of cysteine over glutathione and homocysteine in vivo. Analytical Methods, 11 (14): (1857-1867). [PMID:] [10.1039/C8AY02792G] |
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| 44. Qing Jin, Yan Li, Jianzhong Huo, Xiaojun Zhao. (2016) The “off–on” phosphorescent switch of Mn-doped ZnS quantum dots for detection of glutathione in food, wine, and biological samples. SENSORS AND ACTUATORS B-CHEMICAL, 227 (108). [PMID:] [10.1016/j.snb.2015.12.036] |
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