Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Basic Description
| Synonyms | NEM | maleic acid N-ethylimide | NSC92547 | NSC-92547 | USAF B-121 | ethylmaleimide | HSCI1_000382 | N-ethylmaleimide | 1-Ethyl-1H-pyrrole-2,5-dione | EU-0100492 | GTPL5335 | N-Ethylmaleimide, purum p.a., >=99.0% (HPLC) | MFCD00005509 | NCGC00015415-04 | |
|---|---|
| Specifications & Purity | Moligand™, SuperPure grade, ≥99% |
| Biochemical and Physiological Mechanisms | Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases. |
| Storage Temp | Store at 2-8°C,Argon charged |
| Shipped In | Wet ice |
| Grade | Moligand™, SuperPure grade |
| Product Description | Reagent for the covalent modification of cysteine residues in proteins. |
Associated Targets(Human)
TYMS Tclin Thymidylate synthase (1651 Activities)
MAOB Tclin Monoamine oxidase B (8835 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SLC6A3 Tclin Dopamine transporter (10535 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALB Tchem Serum albumin (2651 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MCF7 (126967 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HEK293 (82097 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
NCI-H460 (60772 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SF-268 (49410 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MGLL Tchem Monoglyceride lipase (1909 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
LMNA Tbio Prelamin-A/C (36751 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
BLM Tchem Bloom syndrome protein (4248 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
THPO Tbio Thrombopoietin (834 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
GMNN Tbio Geminin (128009 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
IDE Tchem Insulin-degrading enzyme (806 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ATG4B Tchem Cysteine protease ATG4B (985 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ANXA2 Tbio Annexin A2 (15 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SENP1 Tchem Sentrin-specific protease 1 (681 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SENP2 Tchem Sentrin-specific protease 2 (79 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MEST Tbio Mesoderm-specific transcript homolog protein (25 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PHPT1 Tbio 14 kDa phosphohistidine phosphatase (30 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Faah Anandamide amidohydrolase (3907 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Nannizzia gypsea (2039 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Staphylococcus aureus (210822 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Aspergillus flavus (8875 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Aspergillus niger (16508 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Saccharomyces cerevisiae (19171 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Aspergillus fumigatus (16427 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Plasmodium falciparum (966862 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Cryptococcus neoformans (21258 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Candida albicans (78123 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Candida tropicalis (8381 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Trichophyton rubrum (3646 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mus musculus (284745 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Npsr1 Neuropeptide S receptor (260 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
pfk 6-phospho-1-fructokinase (7870 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Trichophyton mentagrophytes (4846 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mapt Microtubule-associated protein tau (6 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mboat4 Ghrelin O-acyltransferase (37 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
crtY Lycopene cyclase (9 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Names and Identifiers
| IUPAC Name | 1-ethylpyrrole-2,5-dione |
|---|---|
| INCHI | InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3 |
| InChi Key | HDFGOPSGAURCEO-UHFFFAOYSA-N |
| Canonical SMILES | CCN1C(=O)C=CC1=O |
| Isomeric SMILES | CCN1C(=O)C=CC1=O |
| WGK Germany | 3 |
| RTECS | UX9625000 |
| Alternate CAS | 25668-22-8,128-53-0,25668-22-8 |
| PubChem CID | 4362 |
| NSC Number | 7638 |
| UN Number | 2928 |
| MeSH Entry Terms | Ethylmaleimide;N Ethylmaleimide;N-Ethylmaleimide |
| Molecular Weight | 125.13 |
| Beilstein | 112448 |
| Reaxy-Rn | 112448 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2202028 | Certificate of Analysis | Mar 18, 2024 | E100553 |
| F2214551 | Certificate of Analysis | Mar 18, 2024 | E100553 |
| F2214552 | Certificate of Analysis | Mar 18, 2024 | E100553 |
| F2214553 | Certificate of Analysis | Mar 18, 2024 | E100553 |
| K2110381 | Certificate of Analysis | Aug 02, 2023 | E100553 |
| C2303491 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| C2303492 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| C2303493 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| C2303494 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| C2303497 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| C2303730 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| C2303745 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| I2404031 | Certificate of Analysis | Nov 25, 2022 | E100553 |
| F2202029 | Certificate of Analysis | Feb 14, 2022 | E100553 |
Show more⌵
Chemical and Physical Properties
| Solubility | Soluble in ethanol, water, chloroform, methanol and toluene. |
|---|---|
| Sensitivity | Light,Heat,Air Sensitive. |
| Flash Point(°F) | 73 °C |
| Flash Point(°C) | 73°C |
| Boil Point(°C) | 210°C |
| Melt Point(°C) | 43-46°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS06, GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H314:Causes severe skin burns and eye damage H317:May cause an allergic skin reaction H300:Fatal if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |
| WGK Germany | 3 |
| RTECS | UX9625000 |
| Reaxy-Rn | 112448 |
| Merck Index | 3822 |
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Citations of This Product
| 1. Guo-Qi Zhang, Wei-ping Liu, Yu-Han Shi, Yu-Xian Zou, Li-Yao Xu, Hui-Ling Cheng, Tao Wang, Wen-Bin Li, Yan Zhao, Zhi-Hong Xu. (2024) Intrinsic peroxidase activity of carbon dots derived from expired drugs and its application in automatic detection of total antioxidant capacity. MICROCHEMICAL JOURNAL, 197 (1): (109720). [PMID:23948568] |
| 2. Gao Lifang, Chen Rong, Li Haixia, Xu Dan, Zheng Danning. (2023) Time-resolved fluorescence nanoprobe of acetylcholinesterase based on ZnGeO:Mn luminescence nanorod modified with metal ions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (29): (7047-7055). [PMID:37889311] |
| 3. Li Huang, Shangying Qin, Kun Yang, Yuanjin Xu, Xiaocui Wu, Zhongwei Lin, Yilin Wang. (2024) Dual signal AA detection based on fluorescence and local surface plasmon resonance absorption technology. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 306 (28): (123570). [PMID:24751536] |
| 4. Jia Chen, Shengrong Yu, Zhiling Qian, Kangdi He, Bingqian Li, Yuting Cao, Keqi Tang, Shengjia Yu, Yong-Xiang Wu. (2023) Target-triggered enzyme-free amplification for highly efficient AND-gated bioimaging in living cells. ANALYST, (24): [PMID:37867382] |
| 5. Ruiling Li, Na Wu, Hui Xue, Binghong Gao, Huilan Liu, Tianfeng Han, Xiaobo Hu, Yonggang Tu, Yan Zhao. (2023) Influence and effect mechanism of disulfide bonds linkages between protein-coated lipid droplets and the protein matrix on the physicochemical properties, microstructure, and protein structure of ovalbumin emulsion gels. COLLOIDS AND SURFACES B-BIOINTERFACES, 223 (113182). [PMID:36736177] |
| 6. Xu Yang, Maosheng Lin, Jirui Wei, Jing Sun. (2023) A self-crosslinking nanogel scaffold for enhanced catalytic efficiency and stability. Polymer Chemistry, 14 (3): (284-294). [PMID:] |
| 7. Shaoxiong Wu, Lianyuan Wang, Haiyan Zhu, Jing Liang, Liang Ge, Cong Li, Ting Miao, Jian Li, Zhenxing Cheng. (2022) Catalytic degradation of CWAs with MOF-808 and PCN-222: Toward practical application. JOURNAL OF CHEMICAL RESEARCH, [PMID:] |
| 8. Yu Wang, Yu Xue, Qilin Zhao, Shuang Wang, Jian Sun, Xiurong Yang. (2022) Colorimetric Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Metal–Organic Framework Nanosheets. ANALYTICAL CHEMISTRY, 94 (47): (16345–16352). [PMID:36444539] |
| 9. Zhenyu Ding, Zhe Li, Xiaoxue Zhao, Yanrong Miao, Zhenfeng Yuan, Yuanyuan Jiang, Yizhong Lu. (2023) Self-deposited ultrasmall Ru nanoparticles on carbon nitride with high peroxidase-mimicking activity for the colorimetric detection of alkaline phosphatase. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 631 (86). [PMID:36368217] |
| 10. Zhiwen Gan, Tian Zhang, Xuanxuan An, Qin Tan, Shujun Zhen, Yongmei Hu, Xiaoli Hu. (2022) Dual enzyme-mimicking fluorescent amino terephthalic acid/CuFe/adenosine triphosphate nanoparticles for determination of H2O2 and ascorbic acid. MICROCHEMICAL JOURNAL, 182 (107939). [PMID:] |
References
| 1. Guo-Qi Zhang, Wei-ping Liu, Yu-Han Shi, Yu-Xian Zou, Li-Yao Xu, Hui-Ling Cheng, Tao Wang, Wen-Bin Li, Yan Zhao, Zhi-Hong Xu. (2024) Intrinsic peroxidase activity of carbon dots derived from expired drugs and its application in automatic detection of total antioxidant capacity. MICROCHEMICAL JOURNAL, 197 (1): (109720). [PMID:23948568] |
| 2. Gao Lifang, Chen Rong, Li Haixia, Xu Dan, Zheng Danning. (2023) Time-resolved fluorescence nanoprobe of acetylcholinesterase based on ZnGeO:Mn luminescence nanorod modified with metal ions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (29): (7047-7055). [PMID:37889311] |
| 3. Li Huang, Shangying Qin, Kun Yang, Yuanjin Xu, Xiaocui Wu, Zhongwei Lin, Yilin Wang. (2024) Dual signal AA detection based on fluorescence and local surface plasmon resonance absorption technology. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 306 (28): (123570). [PMID:24751536] |
| 4. Jia Chen, Shengrong Yu, Zhiling Qian, Kangdi He, Bingqian Li, Yuting Cao, Keqi Tang, Shengjia Yu, Yong-Xiang Wu. (2023) Target-triggered enzyme-free amplification for highly efficient AND-gated bioimaging in living cells. ANALYST, (24): [PMID:37867382] |
| 5. Ruiling Li, Na Wu, Hui Xue, Binghong Gao, Huilan Liu, Tianfeng Han, Xiaobo Hu, Yonggang Tu, Yan Zhao. (2023) Influence and effect mechanism of disulfide bonds linkages between protein-coated lipid droplets and the protein matrix on the physicochemical properties, microstructure, and protein structure of ovalbumin emulsion gels. COLLOIDS AND SURFACES B-BIOINTERFACES, 223 (113182). [PMID:36736177] |
| 6. Xu Yang, Maosheng Lin, Jirui Wei, Jing Sun. (2023) A self-crosslinking nanogel scaffold for enhanced catalytic efficiency and stability. Polymer Chemistry, 14 (3): (284-294). [PMID:] |
| 7. Shaoxiong Wu, Lianyuan Wang, Haiyan Zhu, Jing Liang, Liang Ge, Cong Li, Ting Miao, Jian Li, Zhenxing Cheng. (2022) Catalytic degradation of CWAs with MOF-808 and PCN-222: Toward practical application. JOURNAL OF CHEMICAL RESEARCH, [PMID:] |
| 8. Yu Wang, Yu Xue, Qilin Zhao, Shuang Wang, Jian Sun, Xiurong Yang. (2022) Colorimetric Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Metal–Organic Framework Nanosheets. ANALYTICAL CHEMISTRY, 94 (47): (16345–16352). [PMID:36444539] |
| 9. Zhenyu Ding, Zhe Li, Xiaoxue Zhao, Yanrong Miao, Zhenfeng Yuan, Yuanyuan Jiang, Yizhong Lu. (2023) Self-deposited ultrasmall Ru nanoparticles on carbon nitride with high peroxidase-mimicking activity for the colorimetric detection of alkaline phosphatase. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 631 (86). [PMID:36368217] |
| 10. Zhiwen Gan, Tian Zhang, Xuanxuan An, Qin Tan, Shujun Zhen, Yongmei Hu, Xiaoli Hu. (2022) Dual enzyme-mimicking fluorescent amino terephthalic acid/CuFe/adenosine triphosphate nanoparticles for determination of H2O2 and ascorbic acid. MICROCHEMICAL JOURNAL, 182 (107939). [PMID:] |