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N-Methyl-D-aspartic acid - ≥98%, high purity , CAS No.6384-92-5, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

Moligand™
≥98%

CAS#: 6384-92-5
Formula: C₅H₉NO₄
Molecular Weight: 147.13
Beilstein Registry Number: 1724431
MDL number: MFCD00004226
PubChem CID: 22880

Item Number

N129532

Grouped product items
SKU	Size	Availability	Price
N129532-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$94.90
N129532-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$213.90
N129532-1g	1g	In stock	$769.90
N129532-5g	5g	In stock	$3,462.90

Excitotoxic amino acid

View related series

GluN1 Agonist GluN2A Agonist GluN2B Agonist GluN2C Agonist GluN2D Agonist

Basic Description

Synonyms	N-methyl-D-aspartic acid\|NMDA\|6384-92-5\|N-Methylaspartate\|N-Methyl-D-aspartate\|D-Aspartic acid, N-methyl-\|Methyl aspartic acid\|(R)-2-(Methylamino)succinic acid\|n-methyl-d-aspartic acid (nmda)\|(2R)-2-(methylamino)butanedioic acid\|N-Methyl aspartic acid\|(R)
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D
Product Description	N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel intimately involved in spatial learning and memory, and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.

Associated Targets

HPN Tchem Serine protease hepsin 0 Activities

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A 0 Activities

Discover Target: GRIN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B 0 Activities

Discover Target: GRIN2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Discover Target: GRIN2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D 0 Activities

Discover Target: GRIN2D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2R)-2-(methylamino)butanedioic acid
INCHI	InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChi Key	HOKKHZGPKSLGJE-GSVOUGTGSA-N
Canonical SMILES	CNC(CC(=O)O)C(=O)O
Isomeric SMILES	CN[C@H](CC(=O)O)C(=O)O
RTECS	CI9457000
PubChem CID	22880
Molecular Weight	147.13
Beilstein	1724431
Reaxy-Rn	1724431

PubChem CID

Wikipedia

ChEBI

CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
B2209146	Certificate of Analysis	Nov 15, 2023	N129532
C1918144	Certificate of Analysis	Nov 18, 2022	N129532
K2216300	Certificate of Analysis	Nov 18, 2022	N129532
L1419013	Certificate of Analysis	Jul 18, 2022	N129532

Solubility

DMSO 5 mg/mL Water 30 mg/mL Ethanol <1 mg/mL

Specific Rotation[α]

-15° (C=2,H2O)

Melt Point(°C)

178 °C

RTECS

CI9457000

Reaxy-Rn

1724431

Merck Index

6662

References

1. Kiragasi B et al.. (2017) A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation.. Cell Rep, 19 (13): (2694-2706). [PMID:28658618]
2. Girling KD et al.. (2018) Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.. J Neurosci Res, 96 (3): (391-406). [PMID:29193273]
3. Chamma I et al.. (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.. J Neurosci, 33 (39): (15488-503). [PMID:24068817]
4. Sanchez AB et al.. (2016) Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage.. Antimicrob Agents Chemother, 60 (168-79). [PMID:26482305]
5. Ho JW et al.. (2011) Contributions of area Te2 to rat recognition memory.. Learn Mem, 18 (7): (493-501). [PMID:21700715]
6. Zhang S et al.. (2013) Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.. J Neurosci, 33 (18): (7997-8008). [PMID:23637190]
7. Špirková A et al.. (2022) Glutamate can act as a signaling molecule in mouse preimplantation embryos†.. Biol Reprod, 107 (4): (916-927). [PMID:35746896]
8. Grosser S et al.. (2014) Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.. PLoS One, 9 (e86250). [PMID:24465989]
9. Thaney VE et al.. (2017) IFNß Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury.. Sci Rep, 7 (46514). [PMID:28425451]
10. Ledonne A et al.. (2014) Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.. Mol Psychiatry, [PMID:25266126]
11. Bowers MS et al.. (2020) NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.. J Neurochem, 152 (5): (523-541). [PMID:31376158]
12. Feligioni M et al.. (2009) Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals.. Eur J Neurosci, 29 (7): (1348-56). [PMID:19344328]
13. Ramakrishnan L et al.. (2013) Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina.. Eur J Pharmacol, 718 (1-3): (493-501). [PMID:23872399]
14. Sims RE et al.. (2013) Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study.. PLoS One, 8 (e53814). [PMID:23326515]
15. Kiragasi B et al.. (2020) The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation.. Proc Natl Acad Sci U S A, 117 (41): (25830-25839). [PMID:32973097]
16. Incontro S et al.. (2013) The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells.. Biochim Biophys Acta, 1833 (8): (1820-31). [PMID:23545413]
17. Mohr C et al.. (2010) Young age and low temperature, but not female gender delay ATP loss and glutamate release, and protect Purkinje cells during simulated ischemia in cerebellar slices.. Neuropharmacology, 58 (2): (392-403). [PMID:19825379]

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