N-Methyl-D-aspartic acid - ≥98%, high purity , CAS No.6384-92-5, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

Item Number
N129532
Grouped product items
SKUSizeAvailabilityPrice Qty
N129532-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$94.90
N129532-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$213.90
N129532-1g
1g
In stock
$769.90
N129532-5g
5g
In stock
$3,462.90

Excitotoxic amino acid

Basic Description

SynonymsNINDS_000392 | CHEBI:31882 | (R)-2-(Methylamino)succinic acid hydrochloride | KBio2_007072 | NCGC00015666-01 | (2R)-2-(methylamino)butanedioic acid | SR-01000597701-1 | Tox21_500775 | (R)-2-Ethylbutannedioic acid | UNII-1903B9Q6PI | (R)-2-(Methylamino)suc
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsExcitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy. Also available in Kit: Ionotropic agonists . Also available in simple stock solutions ( a
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel intimately involved in spatial learning and memory, and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.

Associated Targets(Human)

HPN Tchem Serine protease hepsin (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR3 Tchem Free fatty acid receptor 3 (304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPN Tchem Serine protease hepsin (242 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Ionotropic glutamate receptor NMDA 1/2D (23 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Trypsin (394 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA (2103 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grik1 Glutamate receptor ionotropic, kainate (722 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2b (1028 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2a (798 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2c (1127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R)-2-(methylamino)butanedioic acid
INCHI InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChi Key HOKKHZGPKSLGJE-GSVOUGTGSA-N
Canonical SMILES CNC(CC(=O)O)C(=O)O
Isomeric SMILES CN[C@H](CC(=O)O)C(=O)O
RTECS CI9457000
PubChem CID 22880
Molecular Weight 147.13
Beilstein 1724431
Reaxy-Rn 1724431

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
B2209146Certificate of AnalysisNov 15, 2023 N129532
C1918144Certificate of AnalysisNov 18, 2022 N129532
K2216300Certificate of AnalysisNov 18, 2022 N129532
L1419013Certificate of AnalysisJul 18, 2022 N129532

Chemical and Physical Properties

SolubilityDMSO 5 mg/mL Water 30 mg/mL Ethanol <1 mg/mL
Specific Rotation[α]-15° (C=2,H2O)
Melt Point(°C)178 °C

Safety and Hazards(GHS)

RTECS CI9457000
Reaxy-Rn 1724431
Merck Index 6662

Related Documents

Citations of This Product

1. Ting Ma, Xiaoxuan Wang, Ting Yu, Juan Liu, Zheqiong Yang, Jinlei Xi.  (2023)  Oxytetracycline changes the behavior of zebrafish larvae by inhibiting NMDA receptors.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  262  (115344).  [PMID:37567108] [10.1016/j.ecoenv.2023.115344]
2. Meixi He, Yi Wang, Xiaozhe Zhang, Lihua Zhang.  (2023)  Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors.  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,      [PMID:36591642] [10.1080/07391102.2022.2159527]
3. Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang.  (2022)  Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume.  FITOTERAPIA,  163  (105338).  [PMID:36270560] [10.1016/j.fitote.2022.105338]

References

1. Kiragasi B et al..  (2017)  A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation..  Cell Rep,  19  (13): (2694-2706).  [PMID:28658618]
2. Girling KD et al..  (2018)  Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity..  J Neurosci Res,  96  (3): (391-406).  [PMID:29193273]
3. Chamma I et al..  (2013)  Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons..  J Neurosci,  33  (39): (15488-503).  [PMID:24068817]
4. Sanchez AB et al..  (2016)  Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage..  Antimicrob Agents Chemother,  60  (168-79).  [PMID:26482305]
5. Ho JW et al..  (2011)  Contributions of area Te2 to rat recognition memory..  Learn Mem,  18  (7): (493-501).  [PMID:21700715]
6. Zhang S et al..  (2013)  Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries..  J Neurosci,  33  (18): (7997-8008).  [PMID:23637190]
7. Špirková A et al..  (2022)  Glutamate can act as a signaling molecule in mouse preimplantation embryos†..  Biol Reprod,  107  (4): (916-927).  [PMID:35746896]
8. Grosser S et al..  (2014)  Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model..  PLoS One,  (e86250).  [PMID:24465989]
9. Thaney VE et al..  (2017)  IFNß Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury..  Sci Rep,  (46514).  [PMID:28425451]
10. Ledonne A et al..  (2014)  Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons..  Mol Psychiatry,      [PMID:25266126]
11. Bowers MS et al..  (2020)  NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor..  J Neurochem,  152  (5): (523-541).  [PMID:31376158]
12. Feligioni M et al..  (2009)  Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals..  Eur J Neurosci,  29  (7): (1348-56).  [PMID:19344328]
13. Ramakrishnan L et al..  (2013)  Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina..  Eur J Pharmacol,  718  (1-3): (493-501).  [PMID:23872399]
14. Sims RE et al..  (2013)  Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study..  PLoS One,  (e53814).  [PMID:23326515]
15. Kiragasi B et al..  (2020)  The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation..  Proc Natl Acad Sci U S A,  117  (41): (25830-25839).  [PMID:32973097]
16. Incontro S et al..  (2013)  The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells..  Biochim Biophys Acta,  1833  (8): (1820-31).  [PMID:23545413]
17. Mohr C et al..  (2010)  Young age and low temperature, but not female gender delay ATP loss and glutamate release, and protect Purkinje cells during simulated ischemia in cerebellar slices..  Neuropharmacology,  58  (2): (392-403).  [PMID:19825379]
18. Ting Ma, Xiaoxuan Wang, Ting Yu, Juan Liu, Zheqiong Yang, Jinlei Xi.  (2023)  Oxytetracycline changes the behavior of zebrafish larvae by inhibiting NMDA receptors.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  262  (115344).  [PMID:37567108] [10.1016/j.ecoenv.2023.115344]
19. Meixi He, Yi Wang, Xiaozhe Zhang, Lihua Zhang.  (2023)  Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors.  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,      [PMID:36591642] [10.1080/07391102.2022.2159527]
20. Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang.  (2022)  Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume.  FITOTERAPIA,  163  (105338).  [PMID:36270560] [10.1016/j.fitote.2022.105338]

Solution Calculators