N-Methyl-N-propargylbenzylamine - >98.0%(GC), high purity , CAS No.555-57-7, Inhibitor of Monoamine oxidase B

5 Citations
Item Number
N159008
Grouped product items
SKUSizeAvailabilityPrice Qty
N159008-1g
1g
In stock
$197.90
N159008-5g
5g
In stock
$889.90
N159008-25g
25g
In stock
$4,001.90
View related series
Monoamine oxidase B Inhibitor

Basic Description

SynonymsPargyline (INN) | BSPBio_002159 | Pargylinum [INN-Latin] | Prestwick1_000183 | 9MV14S8G3E | CBChromo1_000308 | N-benzyl-N-methyl-prop-2-yn-1-amine | N-benzyl-N-methylprop-2-yn-1-amine | Pargyline [INN:BAN] | NCGC00015841-07 | Benzyl-methyl-2-propinylamin
Specifications & PurityMoligand™, ≥98%(GC)
Storage TempArgon charged
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Monoamine oxidase B

Associated Targets(Human)

MAOB Tclin Amine oxidase [flavin-containing] B (29 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOA Tclin Amine oxidase [flavin-containing] A (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH2 Tclin Aldehyde dehydrogenase (509 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Danio rerio (3092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488179849
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179849
IUPAC Name N-benzyl-N-methylprop-2-yn-1-amine
INCHI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3
InChi Key DPWPWRLQFGFJFI-UHFFFAOYSA-N
Canonical SMILES CN(CC#C)CC1=CC=CC=C1
Isomeric SMILES CN(CC#C)CC1=CC=CC=C1
WGK Germany 3
RTECS DP6475000
PubChem CID 4688
Molecular Weight 159.23

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
J1912055Certificate of AnalysisJul 07, 2023 N159008

Chemical and Physical Properties

SensitivityAir Sensitive
Refractive Index1.522
Flash Point(°F)183.2 °F
Flash Point(°C)84°C
Boil Point(°C)86-88 °C/4 mmHg

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H301:Toxic if swallowed

H311:Toxic in contact with skin

H331:Toxic if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P316:Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS DP6475000
Merck Index 7038

Related Documents

Citations of This Product

1. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie.  (2023)  Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease.  BIOORGANIC CHEMISTRY,  141  (106817).  [PMID:37690318]
2. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie.  (2023)  Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease.  JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,      [PMID:36519319]
3. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai.  (2022)  HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.  BIOORGANIC CHEMISTRY,  122  (105724).  [PMID:35305483]
4. Zhang C, Yang K, Yu S, Su J, Yuan S, Han J, Chen Y, Gu J, Zhou T, Bai R, Xie Y..  (2019)  Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease..  Eur J Med Chem,  180  (367-382).  [PMID:31325784]
5. Jiang X, Guo J, Lv Y, Yao C, Zhang C, Mi Z, Shi Y, Gu J, Zhou T, Bai R, Xie Y..  (2020)  Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity..  Bioorg Med Chem,  28  (12): (115550-115550).  [PMID:32503694]

References

1. Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y.  (2013)  Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells..  Carcinogenesis,  34  (6): (1196-207).  [PMID:23354309]
2. Wei Chen,Jia-Hui Tay,Xiao-Qi Yu,Lin Pu.  (2012-06-26)  Diastereoselective [4 + 1] cycloaddition of alkenyl propargyl acetates with CO catalyzed by [RhCl(CO)2]2..  The Journal of organic chemistry,  77  ((14)): (6215-6222).  [PMID:22725622]
3. Hélène Lebel,Carl Trudel,Cédric Spitz.  (2012-07-04)  Stereoselective intermolecular C-H amination reactions..  Chemical communications (Cambridge, England),  48  ((63)): (7799-7801).  [PMID:22751570]
4. José Luis García Ruano,Leyre Marzo,Vanesa Marcos,Cuauhtémoc Alvarado,José Alemán.  (2012-08-01)  Highly stereoselective synthesis of tertiary propargylic centers and their isomerization to enantiomerically enriched allenes..  Chemistry (Weinheim an der Bergstrasse, Germany),  18  ((32)): (9775-9779).  [PMID:22847833]
5. Leleti Rajender Reddy.  (2012-08-09)  Chiral Brønsted acid catalyzed enantioselective allenylation of aldehydes..  Chemical communications (Cambridge, England),  48  ((73)): (9189-9191).  [PMID:22872133]
6. Changming Zhou,Yong Gao,Daoyong Chen.  (2012-08-30)  Investigation of pyridine/propargyl bromide reaction and strong fluorescence enhancements of the resultant poly(propargyl pyridinium bromide)..  The journal of physical chemistry. B,  116  ((37)): (11552-11559).  [PMID:22928912]
7. Amandine Kolleth,Sarah Christoph,Stellios Arseniyadis,Janine Cossy.  (2012-09-22)  Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process..  Chemical communications (Cambridge, England),  48  ((85)): (10511-10513).  [PMID:22996071]
8. Shugao Zhu,Jian Cao,Luling Wu,Xian Huang.  (2012-10-12)  Synthesis of polycyclic isoindoline derivatives via tandem Pd-catalyzed coupling, propargyl-allenyl isomerization, [4 + 2] cycloaddition and aromatization reaction..  The Journal of organic chemistry,  77  ((22)): (10409-10415).  [PMID:23051023]
9. Masahiro Yoshida,Tomotaka Mizuguchi,Kozo Shishido.  (2012-11-09)  Synthesis of oxazolidinones by efficient fixation of atmospheric CO2 with propargylic amines by using a silver/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) Dual-catalyst system..  Chemistry (Weinheim an der Bergstrasse, Germany),  18  ((49)): (15578-15581).  [PMID:23135989]
10. Zheng Jiang,Ping Lu,Yanguang Wang.  (2012-12-01)  Three-component reaction of propargyl amines, sulfonyl azides, and alkynes: one-pot synthesis of tetrasubstituted imidazoles..  Organic letters,  14  ((24)): (6266-6269).  [PMID:23193963]
11. René Csuk,Ronny Sczepek,Bianka Siewert,Christoph Nitsche.  (2012-12-19)  Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis..  Bioorganic & medicinal chemistry,  21  ((2)): (425-435).  [PMID:23245801]
12. Gangadhara R Sareddy,Binoj C Nair,Samaya K Krishnan,Vijay K Gonugunta,Quan-guang Zhang,Takayoshi Suzuki,Naoki Miyata,Andrew J Brenner,Darrell W Brann,Ratna K Vadlamudi.  (2012-12-19)  KDM1 is a novel therapeutic target for the treatment of gliomas..  Oncotarget,  ((1)): (18-28).  [PMID:23248157]
13. Avanashiappan Nandakumar,Paramasivan Thirumalai Perumal.  (2013-01-12)  Tetrasubstituted olefinic xanthene dyes: synthesis via Pd-catalyzed 6-exo-dig cyclization/C-H activation of 2-bromobenzyl-N-propargylamines and solid state fluorescence properties..  Organic letters,  15  ((2)): (382-385).  [PMID:23305124]
14. Ramani Gurubrahamam,Mariappan Periasamy.  (2013-01-17)  Copper(I) halide promoted diastereoselective synthesis of chiral propargylamines and chiral allenes using 2-dialkylaminomethylpyrrolidine, aldehydes, and 1-alkynes..  The Journal of organic chemistry,  78  ((4)): (1463-1470).  [PMID:23320792]
15. María González-Béjar,Kate Peters,Geniece L Hallett-Tapley,Michel Grenier,Juan C Scaiano.  (2013-01-24)  Rapid one-pot propargylamine synthesis by plasmon mediated catalysis with gold nanoparticles on ZnO under ambient conditions..  Chemical communications (Cambridge, England),  49  ((17)): (1732-1734).  [PMID:23340772]
16. Alicia J Avelar,Steven A Juliano,Paul A Garris.  (2013-02-15)  Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms..  Journal of neurochemistry,  125  ((3)): (373-385).  [PMID:23406303]
17. Sandeep N Raikar,Helena C Malinakova.  (2013-03-26)  Divergent reaction pathways of homologous and isosteric propargyl amides in sequential Ru/Pd-catalyzed annulations for the synthesis of heterocycles..  The Journal of organic chemistry,  78  ((8)): (3832-3846).  [PMID:23521584]
18. Daniel R Fandrick,Jonathan T Reeves,Johanna M Bakonyi,Prasanth R Nyalapatla,Zhulin Tan,Oliver Niemeier,Deniz Akalay,Keith R Fandrick,Wolfgang Wohlleben,Swetlana Ollenberger,Jinhua J Song,Xiufeng Sun,Bo Qu,Nizar Haddad,Sanjit Sanyal,Sherry Shen,Shengli Ma,Denis Byrne,Ashish Chitroda,Victor Fuchs,Bikshandarkoil A Narayanan,Nelu Grinberg,Heewon Lee,Nathan Yee,Michael Brenner,Chris H Senanayake.  (2013-04-03)  Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate..  The Journal of organic chemistry,  78  ((8)): (3592-3615).  [PMID:23544787]
19. Ricardo F Schumacher,Alisson R Rosário,Marlon R Leite,Gilson Zeni.  (2013-09-17)  Cyclization of homopropargyl chalcogenides by copper(II) salts: selective synthesis of 2,3-dihydroselenophenes, 3-arylselenophenes, and 3-haloselenophenes/thiophenes..  Chemistry (Weinheim an der Bergstrasse, Germany),  19  ((39)): (13059-13064).  [PMID:24038325]
20. Sergiy Konovalov,Ivan Garcia-Bassets.  (2013-10-30)  Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines..  Journal of ovarian research,  ((1)): (75-75).  [PMID:24165091]
21. Adam L Halberstadt.  (2016-01-19)  Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine..  Pharmacology, biochemistry, and behavior,  143  (1-10).  [PMID:26780349]
22. Markéta Bláhová,Eva Bednářová,Michal Řezanka,Jindřich Jindřich.  (2012-12-05)  Complete sets of monosubstituted γ-cyclodextrins as precursors for further synthesis..  The Journal of organic chemistry,  78  ((2)): (697-701).  [PMID:23205761]
23. S Nag,G Kettschau,T Heinrich,A Varrone,L Lehmann,B Gulyas,A Thiele,É Keller,C Halldin.  (2012-12-06)  Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity..  Bioorganic & medicinal chemistry,  21  ((1)): (186-195).  [PMID:23211968]
24. Hao Wang,Pankaj Jain,Jon C Antilla,K N Houk.  (2013-01-10)  Origins of stereoselectivities in chiral phosphoric acid catalyzed allylborations and propargylations of aldehydes..  The Journal of organic chemistry,  78  ((3)): (1208-1215).  [PMID:23298338]
25. Kimberly A Kaplan,Veronica M Chiu,Peter A Lukus,Xing Zhang,William F Siems,James O Schenk,Herbert H Hill.  (2013-01-15)  Neuronal metabolomics by ion mobility mass spectrometry: cocaine effects on glucose and selected biogenic amine metabolites in the frontal cortex, striatum, and thalamus of the rat..  Analytical and bioanalytical chemistry,  405  ((6)): (1959-1968).  [PMID:23314481]
26. Masahiro Yoshida,Tomomi Nakagawa,Kouki Kinoshita,Kozo Shishido.  (2013-02-01)  Regiocontrolled construction of furo[3,2-c]pyran-4-one derivatives by palladium-catalyzed cyclization of propargylic carbonates with 4-hydroxy-2-pyrones..  The Journal of organic chemistry,  78  ((4)): (1687-1692).  [PMID:23363421]
27. O Yildiz,F Karahalil,Z Can,H Sahin,S Kolayli.  (2013-10-26)  Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis..  Journal of enzyme inhibition and medicinal chemistry,  29  ((5)): (690-694).  [PMID:24156742]
28. Justin R Yates,Mahesh Darna,Cassandra D Gipson,Linda P Dwoskin,Michael T Bardo.  (2015-05-26)  Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency..  Behavioural brain research,  291  (201-208).  [PMID:26005123]
29. Yasushi Ishida,Kosuke Ebihara,Masahiro Tabuchi,Sachiko Imamura,Kyoji Sekiguchi,Kazushige Mizoguchi,Yoshio Kase,Go Koganemaru,Hiroshi Abe,Yasushi Ikarashi.  (2016-01-05)  Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT..  Biological & pharmaceutical bulletin,  39  ((1)): (104-113).  [PMID:26725433]
30. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie.  (2023)  Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease.  BIOORGANIC CHEMISTRY,  141  (106817).  [PMID:37690318]
31. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie.  (2023)  Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease.  JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,      [PMID:36519319]
32. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai.  (2022)  HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.  BIOORGANIC CHEMISTRY,  122  (105724).  [PMID:35305483]
33. Zhang C, Yang K, Yu S, Su J, Yuan S, Han J, Chen Y, Gu J, Zhou T, Bai R, Xie Y..  (2019)  Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease..  Eur J Med Chem,  180  (367-382).  [PMID:31325784]
34. Jiang X, Guo J, Lv Y, Yao C, Zhang C, Mi Z, Shi Y, Gu J, Zhou T, Bai R, Xie Y..  (2020)  Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity..  Bioorg Med Chem,  28  (12): (115550-115550).  [PMID:32503694]

Solution Calculators