Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N159008-1g | 1g | In stock | $197.90 | |
N159008-5g | 5g | In stock | $889.90 | |
N159008-25g | 25g | In stock | $4,001.90 |
Synonyms | Pargyline (INN) | BSPBio_002159 | Pargylinum [INN-Latin] | Prestwick1_000183 | 9MV14S8G3E | CBChromo1_000308 | N-benzyl-N-methyl-prop-2-yn-1-amine | N-benzyl-N-methylprop-2-yn-1-amine | Pargyline [INN:BAN] | NCGC00015841-07 | Benzyl-methyl-2-propinylamin |
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Specifications & Purity | Moligand™, ≥98%(GC) |
Storage Temp | Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Monoamine oxidase B |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179849 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179849 |
IUPAC Name | N-benzyl-N-methylprop-2-yn-1-amine |
INCHI | InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3 |
InChi Key | DPWPWRLQFGFJFI-UHFFFAOYSA-N |
Canonical SMILES | CN(CC#C)CC1=CC=CC=C1 |
Isomeric SMILES | CN(CC#C)CC1=CC=CC=C1 |
WGK Germany | 3 |
RTECS | DP6475000 |
PubChem CID | 4688 |
Molecular Weight | 159.23 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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J1912055 | Certificate of Analysis | Jul 07, 2023 | N159008 |
Sensitivity | Air Sensitive |
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Refractive Index | 1.522 |
Flash Point(°F) | 183.2 °F |
Flash Point(°C) | 84°C |
Boil Point(°C) | 86-88 °C/4 mmHg |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DP6475000 |
Merck Index | 7038 |
1. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie. (2023) Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease. BIOORGANIC CHEMISTRY, 141 (106817). [PMID:37690318] [10.1016/j.bioorg.2023.106817] |
2. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie. (2023) Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, [PMID:36519319] [10.1080/14756366.2022.2134358] |
3. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai. (2022) HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids. BIOORGANIC CHEMISTRY, 122 (105724). [PMID:35305483] [10.1016/j.bioorg.2022.105724] |
4. Zhang C, Yang K, Yu S, Su J, Yuan S, Han J, Chen Y, Gu J, Zhou T, Bai R, Xie Y.. (2019) Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.. Eur J Med Chem, 180 (367-382). [PMID:31325784] [10.1016/j.ejmech.2019.07.031] |
5. Jiang X, Guo J, Lv Y, Yao C, Zhang C, Mi Z, Shi Y, Gu J, Zhou T, Bai R, Xie Y.. (2020) Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.. Bioorg Med Chem, 28 (12): (115550-115550). [PMID:32503694] [10.1016/j.bmc.2020.115550] |
1. Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y. (2013) Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.. Carcinogenesis, 34 (6): (1196-207). [PMID:23354309] [10.1021/op500134e] |
2. Wei Chen,Jia-Hui Tay,Xiao-Qi Yu,Lin Pu. (2012-06-26) Diastereoselective [4 + 1] cycloaddition of alkenyl propargyl acetates with CO catalyzed by [RhCl(CO)2]2.. The Journal of organic chemistry, 77 ((14)): (6215-6222). [PMID:22725622] |
3. Hélène Lebel,Carl Trudel,Cédric Spitz. (2012-07-04) Stereoselective intermolecular C-H amination reactions.. Chemical communications (Cambridge, England), 48 ((63)): (7799-7801). [PMID:22751570] |
4. José Luis García Ruano,Leyre Marzo,Vanesa Marcos,Cuauhtémoc Alvarado,José Alemán. (2012-08-01) Highly stereoselective synthesis of tertiary propargylic centers and their isomerization to enantiomerically enriched allenes.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((32)): (9775-9779). [PMID:22847833] |
5. Leleti Rajender Reddy. (2012-08-09) Chiral Brønsted acid catalyzed enantioselective allenylation of aldehydes.. Chemical communications (Cambridge, England), 48 ((73)): (9189-9191). [PMID:22872133] |
6. Changming Zhou,Yong Gao,Daoyong Chen. (2012-08-30) Investigation of pyridine/propargyl bromide reaction and strong fluorescence enhancements of the resultant poly(propargyl pyridinium bromide).. The journal of physical chemistry. B, 116 ((37)): (11552-11559). [PMID:22928912] |
7. Amandine Kolleth,Sarah Christoph,Stellios Arseniyadis,Janine Cossy. (2012-09-22) Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process.. Chemical communications (Cambridge, England), 48 ((85)): (10511-10513). [PMID:22996071] |
8. Shugao Zhu,Jian Cao,Luling Wu,Xian Huang. (2012-10-12) Synthesis of polycyclic isoindoline derivatives via tandem Pd-catalyzed coupling, propargyl-allenyl isomerization, [4 + 2] cycloaddition and aromatization reaction.. The Journal of organic chemistry, 77 ((22)): (10409-10415). [PMID:23051023] |
9. Masahiro Yoshida,Tomotaka Mizuguchi,Kozo Shishido. (2012-11-09) Synthesis of oxazolidinones by efficient fixation of atmospheric CO2 with propargylic amines by using a silver/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) Dual-catalyst system.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((49)): (15578-15581). [PMID:23135989] |
10. Zheng Jiang,Ping Lu,Yanguang Wang. (2012-12-01) Three-component reaction of propargyl amines, sulfonyl azides, and alkynes: one-pot synthesis of tetrasubstituted imidazoles.. Organic letters, 14 ((24)): (6266-6269). [PMID:23193963] |
11. René Csuk,Ronny Sczepek,Bianka Siewert,Christoph Nitsche. (2012-12-19) Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis.. Bioorganic & medicinal chemistry, 21 ((2)): (425-435). [PMID:23245801] |
12. Gangadhara R Sareddy,Binoj C Nair,Samaya K Krishnan,Vijay K Gonugunta,Quan-guang Zhang,Takayoshi Suzuki,Naoki Miyata,Andrew J Brenner,Darrell W Brann,Ratna K Vadlamudi. (2012-12-19) KDM1 is a novel therapeutic target for the treatment of gliomas.. Oncotarget, 4 ((1)): (18-28). [PMID:23248157] |
13. Avanashiappan Nandakumar,Paramasivan Thirumalai Perumal. (2013-01-12) Tetrasubstituted olefinic xanthene dyes: synthesis via Pd-catalyzed 6-exo-dig cyclization/C-H activation of 2-bromobenzyl-N-propargylamines and solid state fluorescence properties.. Organic letters, 15 ((2)): (382-385). [PMID:23305124] |
14. Ramani Gurubrahamam,Mariappan Periasamy. (2013-01-17) Copper(I) halide promoted diastereoselective synthesis of chiral propargylamines and chiral allenes using 2-dialkylaminomethylpyrrolidine, aldehydes, and 1-alkynes.. The Journal of organic chemistry, 78 ((4)): (1463-1470). [PMID:23320792] |
15. María González-Béjar,Kate Peters,Geniece L Hallett-Tapley,Michel Grenier,Juan C Scaiano. (2013-01-24) Rapid one-pot propargylamine synthesis by plasmon mediated catalysis with gold nanoparticles on ZnO under ambient conditions.. Chemical communications (Cambridge, England), 49 ((17)): (1732-1734). [PMID:23340772] |
16. Alicia J Avelar,Steven A Juliano,Paul A Garris. (2013-02-15) Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms.. Journal of neurochemistry, 125 ((3)): (373-385). [PMID:23406303] |
17. Sandeep N Raikar,Helena C Malinakova. (2013-03-26) Divergent reaction pathways of homologous and isosteric propargyl amides in sequential Ru/Pd-catalyzed annulations for the synthesis of heterocycles.. The Journal of organic chemistry, 78 ((8)): (3832-3846). [PMID:23521584] |
18. Daniel R Fandrick,Jonathan T Reeves,Johanna M Bakonyi,Prasanth R Nyalapatla,Zhulin Tan,Oliver Niemeier,Deniz Akalay,Keith R Fandrick,Wolfgang Wohlleben,Swetlana Ollenberger,Jinhua J Song,Xiufeng Sun,Bo Qu,Nizar Haddad,Sanjit Sanyal,Sherry Shen,Shengli Ma,Denis Byrne,Ashish Chitroda,Victor Fuchs,Bikshandarkoil A Narayanan,Nelu Grinberg,Heewon Lee,Nathan Yee,Michael Brenner,Chris H Senanayake. (2013-04-03) Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.. The Journal of organic chemistry, 78 ((8)): (3592-3615). [PMID:23544787] |
19. Ricardo F Schumacher,Alisson R Rosário,Marlon R Leite,Gilson Zeni. (2013-09-17) Cyclization of homopropargyl chalcogenides by copper(II) salts: selective synthesis of 2,3-dihydroselenophenes, 3-arylselenophenes, and 3-haloselenophenes/thiophenes.. Chemistry (Weinheim an der Bergstrasse, Germany), 19 ((39)): (13059-13064). [PMID:24038325] |
20. Sergiy Konovalov,Ivan Garcia-Bassets. (2013-10-30) Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines.. Journal of ovarian research, 6 ((1)): (75-75). [PMID:24165091] |
21. Adam L Halberstadt. (2016-01-19) Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.. Pharmacology, biochemistry, and behavior, 143 (1-10). [PMID:26780349] |
22. Markéta Bláhová,Eva Bednářová,Michal Řezanka,Jindřich Jindřich. (2012-12-05) Complete sets of monosubstituted γ-cyclodextrins as precursors for further synthesis.. The Journal of organic chemistry, 78 ((2)): (697-701). [PMID:23205761] |
23. S Nag,G Kettschau,T Heinrich,A Varrone,L Lehmann,B Gulyas,A Thiele,É Keller,C Halldin. (2012-12-06) Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.. Bioorganic & medicinal chemistry, 21 ((1)): (186-195). [PMID:23211968] |
24. Hao Wang,Pankaj Jain,Jon C Antilla,K N Houk. (2013-01-10) Origins of stereoselectivities in chiral phosphoric acid catalyzed allylborations and propargylations of aldehydes.. The Journal of organic chemistry, 78 ((3)): (1208-1215). [PMID:23298338] |
25. Kimberly A Kaplan,Veronica M Chiu,Peter A Lukus,Xing Zhang,William F Siems,James O Schenk,Herbert H Hill. (2013-01-15) Neuronal metabolomics by ion mobility mass spectrometry: cocaine effects on glucose and selected biogenic amine metabolites in the frontal cortex, striatum, and thalamus of the rat.. Analytical and bioanalytical chemistry, 405 ((6)): (1959-1968). [PMID:23314481] |
26. Masahiro Yoshida,Tomomi Nakagawa,Kouki Kinoshita,Kozo Shishido. (2013-02-01) Regiocontrolled construction of furo[3,2-c]pyran-4-one derivatives by palladium-catalyzed cyclization of propargylic carbonates with 4-hydroxy-2-pyrones.. The Journal of organic chemistry, 78 ((4)): (1687-1692). [PMID:23363421] |
27. O Yildiz,F Karahalil,Z Can,H Sahin,S Kolayli. (2013-10-26) Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis.. Journal of enzyme inhibition and medicinal chemistry, 29 ((5)): (690-694). [PMID:24156742] |
28. Justin R Yates,Mahesh Darna,Cassandra D Gipson,Linda P Dwoskin,Michael T Bardo. (2015-05-26) Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency.. Behavioural brain research, 291 (201-208). [PMID:26005123] |
29. Yasushi Ishida,Kosuke Ebihara,Masahiro Tabuchi,Sachiko Imamura,Kyoji Sekiguchi,Kazushige Mizoguchi,Yoshio Kase,Go Koganemaru,Hiroshi Abe,Yasushi Ikarashi. (2016-01-05) Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT.. Biological & pharmaceutical bulletin, 39 ((1)): (104-113). [PMID:26725433] |
30. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie. (2023) Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease. BIOORGANIC CHEMISTRY, 141 (106817). [PMID:37690318] [10.1016/j.bioorg.2023.106817] |
31. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie. (2023) Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, [PMID:36519319] [10.1080/14756366.2022.2134358] |
32. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai. (2022) HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids. BIOORGANIC CHEMISTRY, 122 (105724). [PMID:35305483] [10.1016/j.bioorg.2022.105724] |
33. Zhang C, Yang K, Yu S, Su J, Yuan S, Han J, Chen Y, Gu J, Zhou T, Bai R, Xie Y.. (2019) Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.. Eur J Med Chem, 180 (367-382). [PMID:31325784] [10.1016/j.ejmech.2019.07.031] |
34. Jiang X, Guo J, Lv Y, Yao C, Zhang C, Mi Z, Shi Y, Gu J, Zhou T, Bai R, Xie Y.. (2020) Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.. Bioorg Med Chem, 28 (12): (115550-115550). [PMID:32503694] [10.1016/j.bmc.2020.115550] |