N,N,2-Trimethyl-5-nitrobenzenesulfonamide - 10mM in DMSO, high purity , CAS No.433695-36-4

Item Number

N423955

• Synonyms: 433695-36-4 | BRL-50481 | BRL 50481 | N,N,2-trimethyl-5-nitrobenzenesulfonamide | 5-Nitro-2,N,N-trimethylbenzenesulfonamide | N,N,2-Trimethyl-5-nitro-benzenesulfonamide | Benzenesulfonamide, N,N,2-trimethyl-5-nitro- | BRL50481 | CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzen
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).Selective, competitive PDE7 inhibitor (IC 50 values are 0.15 and 12.1 μm for PDE7A and PDE7B respectively). Active in vivo and in vitro . Potentiates the anti-inflammatory effect of PDE4 i
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.