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N-(n-Butyl)deoxygalactonojirimycin - 98%, high purity , Ceramide glucosyltransferase inhibitor, CAS No.141206-42-0, Ceramide glucosyltransferase inhibitor

≥98%

CAS#: 141206-42-0
Formula: C₁₀H₂₁NO₄
Molecular Weight: 219.28
PubChem CID: 501391

Item Number

N342956

Grouped product items
SKU	Size	Availability	Price	Qty
N342956-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$237.90

a potent and selective inhibitor of α-D-galactosidase

Basic Description

Synonyms	Lucerastat \| 141206-42-0 \| (2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol \| N-(n-Butyl)deoxygalactonojirimycin \| Lucerastat [INN] \| Lucerastat [USAN] \| NB-DGJ \| ACT-434964 \| GVS3YDM418 \| CHEMBL1086997 \| N-Butyldeoxygalactonojirimycin \| N-Butyl-DGJ \| UNII-GVS3YDM41
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Ceramide glucosyltransferase inhibitor
Product Description	N-(n-Butyl)deoxygalactonojirimycin is an extremely potent and selective α-gal A (a-D-galactosidase) inhibitor. Also a selective inhibitior of GlcCer synthesis.

pKa

pKa: 13.72 (Predicted), pKa: 6.94 (Predicted)

ALogP

-0.6

Associated Targets(Human)

GBA2 Tchem Non-lysosomal glucosylceramidase (2 Activities)

Discover Target: GBA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SI Tchem Sucrase-isomaltase, intestinal (1 Activities)

Discover Target: SI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGAM Tclin Maltase-glucoamylase (654 Activities)

Discover Target: MGAM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGCG Tclin Ceramide glucosyltransferase (308 Activities)

Discover Target: UGCG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLB1 Tchem Beta-galactosidase (339 Activities)

Discover Target: GLB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

Discover Target: GBA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA2 Tchem Beta-glucosidase (258 Activities)

Discover Target: GBA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SI Tchem Sucrase-isomaltase (84 Activities)

Discover Target: SI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGL Tbio Glycogen debranching enzyme (27 Activities)

Discover Target: AGL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LCT Tbio Lactase-phlorizin hydrolase (37 Activities)

Discover Target: LCT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
INCHI	InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9+,10-/m1/s1
InChi Key	UQRORFVVSGFNRO-XFWSIPNHSA-N
Canonical SMILES	CCCCN1CC(C(C(C1CO)O)O)O
Isomeric SMILES	CCCCN1C[C@@H]([C@H]([C@H]([C@H]1CO)O)O)O
PubChem CID	501391
Molecular Weight	219.28

Solubility

Soluble in methanol (5 mg/ml), and water (1 mg/ml).

Refractive Index

n20D1.55 (Predicted)

Boil Point(°C)

~394.7° C at 760 mmHg (Predicted)

Melt Point(°C)

123-124° C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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N-(n-Butyl)deoxygalactonojirimycin - 98%, high purity , Ceramide glucosyltransferase inhibitor, CAS No.141206-42-0, Ceramide glucosyltransferase inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

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