Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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D275881-5mg | 5mg | In stock | $77.90 | |
D275881-10mg | 10mg | In stock | $116.90 | |
D275881-25mg | 25mg | In stock | $263.90 | |
D275881-50mg | 50mg | In stock | $521.90 | |
D275881-100mg | 100mg | In stock | $939.90 | |
D275881-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,114.90 |
Selective, potent, reversible and ATP competitive p97 ATPase inhibitor
Synonyms | benzyl-[2-(benzylamino)quinazolin-4-yl]amine;hydrochloride | KSC-16-67 | BCP07830 | KSC-231-18-1 | Oprea1_067556 | Z57159630 | N2,N4-dibenzylquinazoline-2,4-diamine | SW208073-2 | 2,4-Quinazolinediamine, N,N'-bis(phenylmethyl)- | KUC105555N-02 | s7199 | K |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Selective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC 50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. DBeQ is a potent and specific |
Source | Synthetic |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | The product can be stored for up to 12 months. Application HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-N,4-N-dibenzylquinazoline-2,4-diamine |
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INCHI | InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26) |
InChi Key | QAIMUUJJAJBPCL-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4 |
Isomeric SMILES | C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4 |
PubChem CID | 676352 |
Molecular Weight | 340.42 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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F2403386 | Certificate of Analysis | Apr 07, 2024 | D275881 |
A2206066 | Certificate of Analysis | Jul 12, 2023 | D275881 |
A2206067 | Certificate of Analysis | Jul 12, 2023 | D275881 |
A2206068 | Certificate of Analysis | Jul 12, 2023 | D275881 |
A2206069 | Certificate of Analysis | Jul 12, 2023 | D275881 |
A2206072 | Certificate of Analysis | Jul 12, 2023 | D275881 |
A2206073 | Certificate of Analysis | Jul 12, 2023 | D275881 |
Solubility | Soluble in DMSO to 100 mM and in ethanol to 20 mM |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 147.0 to 151.0 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. |