N,N'-Dibenzylquinazoline-2,4-diamine - ≥99%, high purity , CAS No.177355-84-9

  • ≥99%
Item Number
D275881
Grouped product items
SKUSizeAvailabilityPrice Qty
D275881-5mg
5mg
In stock
$77.90
D275881-10mg
10mg
In stock
$116.90
D275881-25mg
25mg
In stock
$263.90
D275881-50mg
50mg
In stock
$521.90
D275881-100mg
100mg
In stock
$939.90
D275881-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,114.90

Selective, potent, reversible and ATP competitive p97 ATPase inhibitor

Basic Description

Synonymsbenzyl-[2-(benzylamino)quinazolin-4-yl]amine;hydrochloride | KSC-16-67 | BCP07830 | KSC-231-18-1 | Oprea1_067556 | Z57159630 | N2,N4-dibenzylquinazoline-2,4-diamine | SW208073-2 | 2,4-Quinazolinediamine, N,N'-bis(phenylmethyl)- | KUC105555N-02 | s7199 | K
Specifications & Purity≥99%
Biochemical and Physiological MechanismsSelective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC 50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. DBeQ is a potent and specific
SourceSynthetic
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

The product can be stored for up to 12 months.


Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Associated Targets(Human)

HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T-24 (2342 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAD52 Tchem DNA repair protein RAD52 homolog (856 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania amazonensis (3813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero C1008 (1716 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-N,4-N-dibenzylquinazoline-2,4-diamine
INCHI InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChi Key QAIMUUJJAJBPCL-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
Isomeric SMILES C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
PubChem CID 676352
Molecular Weight 340.42

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
F2403386Certificate of AnalysisApr 07, 2024 D275881
A2206066Certificate of AnalysisJul 12, 2023 D275881
A2206067Certificate of AnalysisJul 12, 2023 D275881
A2206068Certificate of AnalysisJul 12, 2023 D275881
A2206069Certificate of AnalysisJul 12, 2023 D275881
A2206072Certificate of AnalysisJul 12, 2023 D275881
A2206073Certificate of AnalysisJul 12, 2023 D275881

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM and in ethanol to 20 mM
SensitivityHeat Sensitive
Melt Point(°C)147.0 to 151.0 °C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H319:Causes serious eye irritation

H302:Harmful if swallowed

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

Related Documents

Solution Calculators