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N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine - 10mM in DMSO, high purity , CAS No.16858-02-9
Basic Description Synonyms TPEN | 16858-02-9 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine | TPEDA | N1,N1,N2,N2-Tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine | N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine | 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)- | MFCD0003691 Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 s Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N,N,N',N'-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine INCHI InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2 InChi Key CVRXLMUYFMERMJ-UHFFFAOYSA-N Canonical SMILES C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4 Isomeric SMILES C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4 WGK Germany 3 PubChem CID 5519 Molecular Weight 424.55 Beilstein 4211980 Reaxy-Rn 4211982
Chemical and Physical Properties Melt Point(°C) 112 °C(dec.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 Reaxy-Rn 4211982
Citations of This Product 1. Yan Liang, Jinjin Wang, Chenlu Xu, Wenshuai Han, Sixuan Wu, Yonghua Wu, Jingge Zhang, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang. (2023) Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis. Advanced Science, (2300127). [PMID:37088730 ] [10.1002/advs.202300127 ]
References 1. Yan Liang, Jinjin Wang, Chenlu Xu, Wenshuai Han, Sixuan Wu, Yonghua Wu, Jingge Zhang, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang. (2023) Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis. Advanced Science, (2300127). [PMID:37088730 ] [10.1002/advs.202300127 ]
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