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N474215-5g

Available within 8-12 weeks(?)

$380.90

Basic Description

Synonyms	13118-04-2 \| N,N'-o-Phenylenedimaleimide \| N,N'-2-Phenylenedimaleimide \| 1,2-Phenylene-bis-maleimide \| 1-[2-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione \| N,N'-(o-Phenylene)dimaleimide \| MLS002638335 \| 1,1'-benzene-1,2-diylbis(1H-pyrrole-2,5-dione) \| N,N'-1,2-Phenylene
Specifications & Purity	≥99%

Associated Targets(Human)

CBX1 Tbio Chromobox protein homolog 1 (0 Activities)

Discover Target: CBX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin (0 Activities)

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLH Tchem DNA polymerase eta (0 Activities)

Discover Target: POLH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (0 Activities)

Discover Target: RAPGEF3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor (0 Activities)

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (0 Activities)

Discover Target: FEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic (0 Activities)

Discover Target: TXNRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WRN Tbio Werner syndrome ATP-dependent helicase (0 Activities)

Discover Target: WRN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR9 Tclin Toll-like receptor 9 (0 Activities)

Discover Target: TLR9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (0 Activities)

Discover Target: SMAD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (0 Activities)

Discover Target: PIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota (0 Activities)

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (0 Activities)

Discover Target: PLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RACGAP1 Tbio Rac GTPase-activating protein 1 (0 Activities)

Discover Target: RACGAP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATXN2 Tbio Ataxin-2 (0 Activities)

Discover Target: ATXN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GNAS Tbio Protein ALEX (0 Activities)

Discover Target: GNAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CGA Tbio Glycoprotein hormones alpha chain (0 Activities)

Discover Target: CGA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor (0 Activities)

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial (0 Activities)

Discover Target: GLS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (0 Activities)

Discover Target: IDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A (0 Activities)

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

Discover Target: GNAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLH Tchem DNA polymerase eta (21678 Activities)

Discover Target: POLH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

Discover Target: SMAD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATXN2 Tbio Ataxin-2 (54410 Activities)

Discover Target: ATXN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

Discover Target: RAPGEF3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CGA Tbio Glycoprotein hormones alpha chain (29278 Activities)

Discover Target: CGA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RACGAP1 Tbio Rac GTPase-activating protein 1 (2057 Activities)

Discover Target: RACGAP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)

Discover Target: WRN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

CHO (4503 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tlr9 Toll-like receptor 9 (360 Activities)

Discover Target: Tlr9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ddn Putative uncharacterized protein (49 Activities)

Discover Target: ddn

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

bla(tem-2) Beta Lactamase (819 Activities)

Discover Target: bla(tem-2)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS3 NS3 (1121 Activities)

Discover Target: NS3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[2-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione
INCHI	InChI=1S/C14H8N2O4/c17-11-5-6-12(18)15(11)9-3-1-2-4-10(9)16-13(19)7-8-14(16)20/h1-8H
InChi Key	UFFVWIGGYXLXPC-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)N2C(=O)C=CC2=O)N3C(=O)C=CC3=O
Isomeric SMILES	C1=CC=C(C(=C1)N2C(=O)C=CC2=O)N3C(=O)C=CC3=O
PubChem CID	83156
Molecular Weight	268.22
Beilstein	249426

Certificates

Certificate of Analysis(COA)

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References

1. Yu YY, Van Wie BJ, Koch AR, Moffett DF, Davis WC. () Preparation and characterization of bifunctional biopolymers for receptor-based liposomal immunosensing.. Biotechnol Prog, [PMID:9548785]
2. Hashimoto M, Majima E, Goto S, Shinohara Y, Terada H. () Fluctuation of the first loop facing the matrix of the mitochondrial ADP/ATP carrier deduced from intermolecular cross-linking of Cys56 residues by bifunctional dimaleimides.. Biochemistry, [PMID:9894001]
3. K N Rajasekharan,M Mayadevi,R Agarwal,M Burke. (1990-03-27) MgADP-induced changes in the structure of myosin S1 near the ATPase-related thiol SH1 probed by cross-linking.. Biochemistry, 29 ((12)): (3006-3013). [PMID:2140048]
4. D Applegate,P Flicker. (1987-05-15) New states of actomyosin.. The Journal of biological chemistry, 262 ((14)): (6856-6863). [PMID:2952657]
5. R T King,L E Greene. (1987-05-05) The conformation of cross-linked actin.S-1 in the presence and absence of ATP.. The Journal of biological chemistry, 262 ((13)): (6128-6134). [PMID:3571250]
6. T Chen,D Applegate,E Reisler. (1985-09-24) Cross-linking of actin to myosin subfragment 1 in the presence of nucleotides.. Biochemistry, 24 ((20)): (5620-5625). [PMID:3878158]
7. R Tellam. (1985-07-30) Mechanism of CaCl2-induced actin polymerization.. Biochemistry, 24 ((16)): (4455-4460). [PMID:4052409]
8. S M Periyasamy,W H Huang,A Askari. (1983-08-25) Subunit associations of (Na+ + K+)-dependent adenosine triphosphatase. Chemical cross-linking studies.. The Journal of biological chemistry, 258 ((16)): (9878-9885). [PMID:6309787]
9. T Katoh,K Tanahashi,Y Hasegawa,F Morita. (1995-01-15) Porcine aorta smooth-muscle myosin contains three species made of different combinations of two 17-kDa essential light-chain isoforms.. European journal of biochemistry, 227 ((1-2)): (459-465). [PMID:7851423]
10. J Wu,D Hardy,H R Kaback. (1999-02-23) Site-directed chemical cross-linking demonstrates that helix IV is close to helices VII and XI in the lactose permease.. Biochemistry, 38 ((6)): (1715-1720). [PMID:10026249]
11. Q Wang,H R Kaback. (1999-03-13) Helix packing in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking: helix I is close to helices V and XI.. Biochemistry, 38 ((10)): (3120-3126). [PMID:10074366]
12. Z Qiu,D A Nicoll,K D Philipson. (2000-10-18) Helix packing of functionally important regions of the cardiac Na(+)-Ca(2+) exchanger.. The Journal of biological chemistry, 276 ((1)): (194-199). [PMID:11035002]
13. Patrick Paumard,Geneviève Arselin,Jacques Vaillier,Stéphane Chaignepain,Katell Bathany,Jean Marie Schmitter,Daniel Brèthes,Jean Velours. (2002-08-14) Two ATP synthases can be linked through subunits i in the inner mitochondrial membrane of Saccharomyces cerevisiae.. Biochemistry, 41 ((33)): (10390-10396). [PMID:12173925]
14. Robbyn L Tuinstra,John W Burgner,Henry M Miziorko. (2002-12-05) Investigation of the oligomeric status of the peroxisomal isoform of human 3-hydroxy-3-methylglutaryl-CoA lyase.. Archives of biochemistry and biophysics, 408 ((2)): (286-294). [PMID:12464283]
15. S S Ghosh,P M Kao,A W McCue,H L Chappelle. (1990-01-01) Use of maleimide-thiol coupling chemistry for efficient syntheses of oligonucleotide-enzyme conjugate hybridization probes.. Bioconjugate chemistry, 1 ((1)): (71-76). [PMID:2128871]
16. G T Stevenson,M J Glennie,F E Paul,F K Stevenson,H F Watts,P Wyeth. (1985-10-01) Preparation and properties of FabIgG, a chimeric univalent antibody designed to attack tumour cells.. Bioscience reports, 5 ((10-11)): (991-998). [PMID:3879458]
17. A Szewczuk. (1984-09-01) [Enzymoimmunologic method of determining biologically active substances and its use].. Postepy higieny i medycyny doswiadczalnej, 38 ((5-6)): (667-679). [PMID:6443022]
18. R R French. (1998-07-17) Production of bispecific and trispecific F(ab)2 and F(ab)3 antibody derivatives.. Methods in molecular biology (Clifton, N.J.), 80 (121-134). [PMID:9664369]
19. J Wu,D Hardy,H R Kaback. (1998-10-01) Transmembrane helix tilting and ligand-induced conformational changes in the lactose permease determined by site-directed chemical crosslinking in situ.. Journal of molecular biology, 282 ((5)): (959-967). [PMID:9753547]
20. J Wu,D Hardy,H R Kaback. (1998-12-08) Tilting of helix I and ligand-induced changes in the lactose permease determined by site-directed chemical cross-linking in situ.. Biochemistry, 37 ((45)): (15785-15790). [PMID:9843383]
21. Yoav Evron,Eric A Johnson,Simeon Pinaula,Richard E McCarty. (2002-03-07) Immunodetection of small o-phenylenebismaleimide-labeled peptides through carrier protein display on polyvinylidene fluoride.. Analytical biochemistry, 302 ((2)): (230-238). [PMID:11878802]
22. Rémi Fronzes,Stéphane Chaignepain,Katell Bathany,Marie-France Giraud,Geneviève Arselin,Jean-Marie Schmitter,Alain Dautant,Jean Velours,Daniel Brèthes. (2003-10-15) Topological and functional study of subunit h of the F1Fo ATP synthase complex in yeast Saccharomyces cerevisiae.. Biochemistry, 42 ((41)): (12038-12049). [PMID:14556635]

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N,N′-(o-Phenylene)dimaleimide - 99%, high purity , CAS No.13118-04-2