N-Oxalylglycine - ≥98%, high purity , CAS No.5262-39-5

Item Number

N341017

• Synonyms: NOG | Oxalylglycine | 2-[(Carboxymethyl)amino]-2-oxoacetic Acid | N-Oxalylglycine | 4idz | 2-(carboxyformamido)acetic acid | oxamic acid, (carboxymethyl)- | AS-60026 | CHEBI:44482 | Glycine, N-(carboxycarbonyl)- | MFCD00913253 | n-oxalyl glycine | Pokkuri
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: N-oxalyl glycine is an inhibitor of α-ketoglutaric acid dependent enzymes and mimics the initial step, but does not initiate the hydroxylation process. N-oxalyl-glycine has been used to inhibit histone lysine demethylases containing the Jumonji C domain.
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice

Product Description

N-Oxalylglycine is a cell permeable α-ketoglutarate analogue that functions as a competitive inhibitor of P4HA and PDI (prolyl 4-hydroxylase) which hydroxylates proline-rich peptides|in vitro|. Studies show that the glycine moiety of N-Oxalylglycine can be modified stereoselectively by acylsulfonamides or anilides binding to the ω-carboxylate group of the molecule resulting in a sharp reduction in activity. In addition, N-Oxalylglycine competes with αKG to bind to taurine/αKG dioxygenase resulting in inhibition of the enzyme. N-Oxalylglycine is an inhibitor of HIF PHD1 and HIF PHD2.