Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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T123226-25mg | 25mg | In stock | $48.90 | |
T123226-100mg | 100mg | In stock | $176.90 | |
T123226-250mg | 250mg | In stock | $396.90 | |
T123226-1g | 1g | In stock | $1,428.90 | |
T123226-5g | 5g | In stock | $6,429.90 |
Irreversible chymotrypsin inhibitor and SMase inhibitor
Synonyms | TPCK | C02088 | NCGC00016020-01 | O-tert-Butylhydroxylamine hydrochloride, >=99% | N-P-tosyl-L-phenylalanyl chloromethyl ketone | NSC 727365 | l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide | NCGC00094419-03 | Tosyl-L-phenylalanylchloromethane | |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of cas |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | N-p-Tosyl-L-phenylalanine chloromethyl ketone has been used:
to investigate whether transcription factor NFκB is involved in renalase expression
to test the role of NF-κB activation
to study its inhibitory effect on chymotrypsin |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|---|---|---|---|---|---|---|
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens |
Pubchem Sid | 488189751 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488189751 |
IUPAC Name | N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide |
INCHI | InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1 |
InChi Key | MQUQNUAYKLCRME-INIZCTEOSA-N |
Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CC=CC=C2)C(=O)CCl |
Isomeric SMILES | CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl |
RTECS | XT5613500 |
PubChem CID | 439647 |
Molecular Weight | 351.85 |
Beilstein | 2895215 |
Reaxy-Rn | 2895215 |
Find and download the COA for your product by matching the lot number on the packaging.
11 results found
Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 | |
Certificate of Analysis | Mar 02, 2023 | T123226 |
Solubility | DMSO: >10 mg/mL (stable for several months at 4°C.) ethanol: 20 mg/mL (stable for several months at 4°C. Stock solutions (10 mM in methanol or ethanol) are stable for several months at 4°C.) |
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Sensitivity | heat sensitive |
Specific Rotation[α] | -87.0 to -91.0 deg(C=1, EtOH) |
Melt Point(°C) | 106.0 to 110.0 °C |
Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H335:May cause respiratory irritation H318:Causes serious eye damage |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
RTECS | XT5613500 |
Reaxy-Rn | 2895215 |