Cell permeable\xa0free radicle\xa0trap. Inhibits LPS-induced NF-κB DNA binding activity, inhibits COX-2 catalytic activity and inhibits lipid peroxidation in rat liver microsomes. Blocks indiction of iNOS by reactive oxygen species.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g). A Cox-2 inhibitor.
1.Zening Zhang, Peng Deng, Yang Chen, Zhiyong He, Fang Qin, Qiuming Chen, Zhaojun Wang, Jie Chen, Maomao Zeng, Hongyang Pan. (2024) Exploration of the synergistic inhibition of 4-methylimidazole and 5-hydroxymethylfurfural in caramel colors by amino acid combinations and potential mechanisms. Food Bioscience, 57 (103471). [PMID:][10.1016/j.fbio.2023.103471]
2.Ming Yuan, Dayun Huang, Zefeng Wang, Xin Chen, Minghua Yang. (2022) Synthesis of ultra-high molecular weight poly(methyl methacrylate) with hydrosilane as initiator. Materials Today Communications, 33 (104927). [PMID:][10.1016/j.mtcomm.2022.104927]
3.Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Zhi-Long Yu, Wei-Cai Zeng. (2022) Effects of Ligustrum robustum (Rxob.) Blume extract on the quality of peanut and palm oils during storage and frying process. JOURNAL OF FOOD SCIENCE, 87 (10):(4504-4521). [PMID:36124403][10.1111/1750-3841.16311]
4.Yingjie Ma, Hairong Huang, Yan Zhang, Feng Li, Bei Gan, Qiang Yu, Jianhua Xie, Yi Chen. (2022) Soluble dietary fiber from tea residues with inhibitory effects against acrylamide and 5-hydroxymethylfurfural formation in biscuits: The role of bound polyphenols. FOOD RESEARCH INTERNATIONAL, 159 (111595). [PMID:35940761][10.1016/j.foodres.2022.111595]
5.Zhou Yulan, Liao Wanfeng, Ni Xiuyuan. (2021) Cationic Photopolymerization Initiated by a Photocatalytic Complex Sensitive to Visible Light at 520 nm. CATALYSIS LETTERS, 151 (6):(1766-1775). [PMID:][10.1007/s10562-020-03437-z]
6.Wanfeng Liao, Xiuyuan Ni, Yulan Zhou. (2018) Cationic and free radical polymerization initiated by a visible-light sensitive complex based on the photocatalytic decarboxylation of carboxylic acid. JOURNAL OF CATALYSIS, 361 (423). [PMID:][10.1016/j.jcat.2018.03.005]
References
1.Zening Zhang, Peng Deng, Yang Chen, Zhiyong He, Fang Qin, Qiuming Chen, Zhaojun Wang, Jie Chen, Maomao Zeng, Hongyang Pan. (2024) Exploration of the synergistic inhibition of 4-methylimidazole and 5-hydroxymethylfurfural in caramel colors by amino acid combinations and potential mechanisms. Food Bioscience, 57 (103471). [PMID:][10.1016/j.fbio.2023.103471]
2.Ming Yuan, Dayun Huang, Zefeng Wang, Xin Chen, Minghua Yang. (2022) Synthesis of ultra-high molecular weight poly(methyl methacrylate) with hydrosilane as initiator. Materials Today Communications, 33 (104927). [PMID:][10.1016/j.mtcomm.2022.104927]
3.Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Zhi-Long Yu, Wei-Cai Zeng. (2022) Effects of Ligustrum robustum (Rxob.) Blume extract on the quality of peanut and palm oils during storage and frying process. JOURNAL OF FOOD SCIENCE, 87 (10):(4504-4521). [PMID:36124403][10.1111/1750-3841.16311]
4.Yingjie Ma, Hairong Huang, Yan Zhang, Feng Li, Bei Gan, Qiang Yu, Jianhua Xie, Yi Chen. (2022) Soluble dietary fiber from tea residues with inhibitory effects against acrylamide and 5-hydroxymethylfurfural formation in biscuits: The role of bound polyphenols. FOOD RESEARCH INTERNATIONAL, 159 (111595). [PMID:35940761][10.1016/j.foodres.2022.111595]
5.Zhou Yulan, Liao Wanfeng, Ni Xiuyuan. (2021) Cationic Photopolymerization Initiated by a Photocatalytic Complex Sensitive to Visible Light at 520 nm. CATALYSIS LETTERS, 151 (6):(1766-1775). [PMID:][10.1007/s10562-020-03437-z]
6.Wanfeng Liao, Xiuyuan Ni, Yulan Zhou. (2018) Cationic and free radical polymerization initiated by a visible-light sensitive complex based on the photocatalytic decarboxylation of carboxylic acid. JOURNAL OF CATALYSIS, 361 (423). [PMID:][10.1016/j.jcat.2018.03.005]
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E2114030