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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B100838-1g | 1g | In stock | $47.90 | |
B100838-5g | 5g | In stock | $184.90 | |
B100838-25g | 25g | In stock | $829.90 |
Inhibitor of LPS-induced NF-κB DNA binding activity and COX-2 catalytic activity
Synonyms | n-tert-butyl-alpha-phenylnitrone|3376-24-7|N-tert-butyl-1-phenylmethanimine oxide|Phenyl-N-tert-butylnitrone|N-tert-Butyl-a-phenylnitrone|N-tert-Butyl-|A-phenylnitrone|benzylidene-tert-butylamine oxide|Pbn [MI]|n-tert-butyl phenyl nitrone|(Z)-benzylidene( |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Cell permeable\xa0free radicle\xa0trap. Inhibits LPS-induced NF-κB DNA binding activity, inhibits COX-2 catalytic activity and inhibits lipid peroxidation in rat liver microsomes. Blocks indiction of iNOS by reactive oxygen species. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g). |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | N-tert-butyl-1-phenylmethanimine oxide |
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INCHI | InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9- |
InChi Key | IYSYLWYGCWTJSG-XFXZXTDPSA-N |
Canonical SMILES | CC(C)(C)[N+](=CC1=CC=CC=C1)[O-] |
Isomeric SMILES | CC(C)(C)/[N+](=C/C1=CC=CC=C1)/[O-] |
WGK Germany | 3 |
RTECS | TX1760000 |
PubChem CID | 638877 |
Molecular Weight | 177.24 |
Beilstein | 2044028 |
Reaxy-Rn | 1841513 |
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Lot Number | Certificate Type | Date | Item |
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E2114030 | Certificate of Analysis | Feb 06, 2024 | B100838 |
F2229267 | Certificate of Analysis | Jun 06, 2022 | B100838 |
F2229437 | Certificate of Analysis | Jun 06, 2022 | B100838 |
F2229439 | Certificate of Analysis | Jun 06, 2022 | B100838 |
C2211230 | Certificate of Analysis | Mar 14, 2022 | B100838 |
Solubility | Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml). |
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Sensitivity | Air Sensitive |
Melt Point(°C) | 72-75°C |
WGK Germany | 3 |
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RTECS | TX1760000 |
Reaxy-Rn | 1841513 |