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N4-Hydroxycytidine - 98%, high purity , CAS No.3258-02-4

Item Number
E412574
Grouped product items
SKUSizeAvailabilityPrice Qty
E412574-5mg
5mg
In stock
$195.90
E412574-25mg
25mg
In stock
$515.90
E412574-100mg
100mg
In stock
$1,033.90
E412574-250mg
250mg
In stock
$2,326.90
E412574-1g
1g
In stock
$8,375.90
E412574-5g
5g
In stock
$37,689.90
E412574-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$169,601.90
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SARS-CoV Inhibitors

Basic Description

SynonymsN4-Hydroxycytidine | 3258-02-4 | EIDD-1931 | Beta-D-N4-hydroxycytidine | N(4)-Hydroxycytidine | Uridine, 4-oxime | N-hydroxycytidine | 4-N-Hydroxycytidine | EiDD1931 | C3D11PV2O4 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one | 1
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsEIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. EIDD-1931 (NHC) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic gro
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Information

EIDD-1931 EIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. EIDD-1931 (NHC) has broad spectrum antiviral activity against SARS-CoV-2 , MERS-CoV , SARS-CoV , and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.

Associated Targets(Human)

MTARC1 Tbio Mitochondrial amidoxime-reducing component 1 (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTARC2 Tbio Mitochondrial amidoxime reducing component 2 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Influenza B virus (2113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Influenza A virus (11224 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BHK-21 (725 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dengue virus type 2 (2400 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Middle East respiratory syndrome-related coronavirus (220 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV (424 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero C1008 (1716 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
INCHI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1
InChi Key XCUAIINAJCDIPM-XVFCMESISA-N
Canonical SMILES C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
Isomeric SMILES C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
PubChem CID 197020
Molecular Weight 259.22

Certificates

Certificate of Analysis(COA)

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13 results found

Lot NumberCertificate TypeDateItem
I2307212Certificate of AnalysisAug 25, 2023 E412574
I2307213Certificate of AnalysisAug 25, 2023 E412574
I2307214Certificate of AnalysisAug 25, 2023 E412574
I2307215Certificate of AnalysisAug 25, 2023 E412574
I2307216Certificate of AnalysisAug 25, 2023 E412574
I2307217Certificate of AnalysisAug 25, 2023 E412574
I2307218Certificate of AnalysisAug 25, 2023 E412574
I2307219Certificate of AnalysisAug 25, 2023 E412574
I2307220Certificate of AnalysisAug 25, 2023 E412574
I2307221Certificate of AnalysisAug 25, 2023 E412574
I2307245Certificate of AnalysisAug 25, 2023 E412574
I2307246Certificate of AnalysisAug 25, 2023 E412574
I2307327Certificate of AnalysisAug 25, 2023 E412574

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Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro Water: 15 mg/mL (57.86 mM); Ethanol: 3 mg/mL (11.57 mM);  
SensitivityAir sensitive；Moisture sensitive；Heat sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

References

1. Chan CL, Jones RL, Lau HY.  (1988)  Bombesin-like peptides in health and disease. Proceedings of an international symposium. October 13-16, 1987, Rome, Italy. A tribute to Vittorio Erspamer, M.D..  Ann NY Acad Sci,  547  (3): (1-541).  [PMID:3071214]

Solution Calculators

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