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N6,2′-O-Dibutyryladenosine 3′,5′ -cyclic monophosphate sodium salt - ≥97% (HPLC), high purity , CAS No.16980-89-5
Cell-permeable cAMP analog
Basic Description Synonyms Dibutyryl cAMP (sodium salt);DBcAMP (sodium salt) | InChI=1/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H | Actosin | Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt | Actosin (TN) | STK803270 | EINECS 243-065-2 | MLS0022071 Specifications & Purity ≥97%(HPLC) Biochemical and Physiological Mechanisms Cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Promotes differentiation of dopaminergic neurons (iDA) from hPSCs in combination with other reagents. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Bucladesine is a membrane permeable selective activator of PKA.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name sodium;[(4aR,6R,7R,7aR)-6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate INCHI InChI=1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1 InChi Key KRBZRVBLIUDQNG-JBVYASIDSA-M Canonical SMILES CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+] Isomeric SMILES CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+] WGK Germany 2 RTECS ES5055500 PubChem CID 23663967 Molecular Weight 491.37
Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 49.14, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 49.14, Max Conc. mM: 100 Sensitivity Heat sensitive
Safety and Hazards(GHS) WGK Germany 2 RTECS ES5055500 Merck Index 1463
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D2412532
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