Nafadotride - ≥99%, high purity , CAS No.149649-22-9, Agonist of 5-HT 1A receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 receptor
Nafadotride - ≥99%, high purity , CAS No.149649-22-9, Agonist of 5-HT 1A receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 receptor
Potent, selective D 3 antagonist (K i values are 0.52 nM (D 3 ), 269 nM (D 4 ) and 5 nM (D 2 )).
Storage Temp
Room temperature,Desiccated
Shipped In
Normal
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST
Mechanism of action
Agonist of 5-HT 1A receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Sautel F, Griffon N, Sokoloff P, Schwartz JC, Launay C, Simon P, Costentin J, Schoenfelder A, Garrido F, Mann A et al.. (1995) Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.. J Pharmacol Exp Ther, 275 (3):(1239-46). [PMID:8531087][10.1021/op500134e]
2.Banasikowski TJ et al.. (2012) Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats.. Behav Pharmacol, 23 (89-97). [PMID:22157177]
3.Kohnomi S et al.. (2012) D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.. J Neurophysiol, 107 (2):(692-703). [PMID:22049335]
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