Naloxone HCl - ≥99%, high purity , Opioid receptors; mu/kappa/delta antagonist, CAS No.357-08-4, Opioid receptors; mu/kappa/delta antagonist

Item Number

N129470

Grouped product items
SKU	Size	Availability	Price
N129470-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$35.90
N129470-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$134.90
N129470-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$415.90
N129470-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,868.90

Opioid antagonist

Basic Description

Synonyms	Naloxone hydrochloride\|Naloxone HCl\|357-08-4\|Narcanti\|Narcan\|Naloxone (hydrochloride)\|Evzio\|Nalonee\|NIH 7890\|EN-15304\|UNII-F850569PQR\|KLOXXADO\|Anhydrous naloxone hydrochloride\|CHEBI:31892\|F850569PQR\|EINECS 206-611-0\|NSC-757109\|17-Allyl-4,5alpha-epoxy-3,14
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	ANTAGONIST
Mechanism of action	Opioid receptors; mu/kappa/delta antagonist

Names and Identifiers

IUPAC Name	(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
INCHI	InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
InChi Key	RGPDIGOSVORSAK-STHHAXOLSA-N
Canonical SMILES	C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
Isomeric SMILES	C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
PubChem CID	5464092
Molecular Weight	363.84

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
C2304791	Certificate of Analysis	Dec 19, 2022	N129470
C2304792	Certificate of Analysis	Dec 19, 2022	N129470
C2304794	Certificate of Analysis	Dec 19, 2022	N129470
C2304798	Certificate of Analysis	Dec 19, 2022	N129470

Solubility

Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml), and DMSO (73 mg/ml). Insoluble in ether.

Sensitivity

Light & Moisture sensitive.

Melt Point(°C)

200-205°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.

References

1. Charlet A et al.. (2010) Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine.. Mol Pain, 6 (96). [PMID:21172011]
2. Arttamangkul S et al.. (2018) Cellular tolerance at the µ-opioid receptor is phosphorylation dependent.. Elife, 7 [PMID:29589831]
3. Liu S et al.. (2019) Effect of endomorphin-2 on orofacial pain induced by orthodontic tooth movement in rats.. Eur J Oral Sci, 127 (5): (408-416). [PMID:31365768]
4. Birdsong WT et al.. (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.. Elife, 8 [PMID:31099753]

Solution Calculators

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Basic Description