NAMPT PROTAC B4 , CAS No.N612152

Item Number

N612152

Grouped product items
SKU	Size	Availability	Price	Qty
N612152-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N612152-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

Synonyms

compound 5

Specifications & Purity

Moligand™

Grade

Moligand™

Associated Targets(Human)

A2780 (11979 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HUVEC (11049 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NAMPT Tchem Nicotinamide phosphoribosyltransferase (3221 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VHL Tchem Von Hippel-Lindau disease tumor suppressor (136 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

INCHI	InChI=1S/C59H73N9O7S/c1-7-31-67-48-32-45(28-29-47(48)65-52(57(67)74)42-22-26-44(27-23-42)55(72)61-35-40-17-16-30-60-34-40)64-50(70)18-14-12-10-8-9-11-13-15-19-51(71)66-54(59(4,5)6)58(75)68-36-46(69)33-49(68)56(73)63-38(2)41-20-24-43(25-21-41)53-39(3)62-37-76-53/h16-17,20-30,32,34,37-38,46,49,54,69H,7-15,18-19,31,33,35-36H2,1-6H3,(H,61,72)(H,63,73)(H,64,70)(H,66,71)/t38-,46+,49-,54+/m0/s1
InChi Key	MLJZDBCOWWJHEE-LPLKMGJNSA-N
Canonical SMILES	O=c1n(CCC)c2c(nc1c1ccc(C(=O)NCc3cnccc3)cc1)ccc(c2)NC(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@H](c1ccc(cc1)c1c(ncs1)C)C)O)C(C)(C)C
Isomeric SMILES	CCCN1C2=C(C=CC(=C2)NC(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@@H](C[C@H]3C(=O)N[C@@H](C)C4=CC=C(C=C4)C5=C(N=CS5)C)O)C(C)(C)C)N=C(C1=O)C6=CC=C(C=C6)C(=O)NCC7=CN=CC=C7
PubChem CID	165437867

References

1. Wang X, Xu TY, Liu XZ, Zhang SL, Wang P, Li ZY, Guan YF, Wang SN, Dong GQ, Zhuo S et al.. (2015) Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT.. Sci Rep, 5 (3): (12657). [PMID:26227784]
2. Cheng J, He S, Xu J, Huang M, Dong G, Sheng C. (2022) Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT.. J Med Chem, 129 (3): (589-97). [PMID:36442664]

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