Natalizumab (anti-ITGA4) - Primary antibody, specific to ITGA4, Human IgG4, Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Natalizumab (anti-ITGA4) - Primary antibody, specific to ITGA4, Human IgG4, Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Product Description
Natalizumab (anti-ITGA4) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab (anti-ITGA4) can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab (anti-ITGA4) is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg
Product Properties
Isotype
Human IgG4
Light Chain Type
kappa
SDS-PAGE
26.1 kDa (Light Chain) & 51.3 kDa (Heavy Chain), under reducing conditions; 192.7 kDa, under non-reducing conditions.
Purification Method
Protein A purified
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
189261-10-7
Images
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of Jurkat cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - SEC The purity of Natalizumab (anti-ITGA4) (Ab175611) is more than 95% verified by HPLC.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of Raji cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of U937 cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of HeLa cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
1.Mackay CR. (2008) Moving targets: cell migration inhibitors as new anti-inflammatory therapies.. Nat Immunol, 9 (9):(988-98). [PMID:18711436]
2.Léger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM. (1997) Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis.. Hum Antibodies, 8 (1):(3-16). [PMID:9265500]
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