Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC 50 of 8 nM. Pain relief. Limited CNS penetration.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC 50 of 8 nM. Pain relief. Limited CNS penetration
In Vivo
Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 male mice (n=8/group, 25-30g) Dosage: 1, 3, and 10 mg/kg Administration: Oral (0-35 mintues) Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase
Form:Solid
IC50& Target:IC50: 8 nM (Nav1.7)
Associated Targets(Human)
SCN5ATclinSodium channel protein type 5 subunit alpha (1 Activities)
