Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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N125945-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $68.90 | |
N125945-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $310.90 | |
N125945-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,117.90 |
Blocks HIV-1 viral cell entry; CD4 mimetic
Synonyms | DTXSID20364454 | AKOS000339835 | J-019150 | Ethanediamide, N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)- | NBD-556 | AS-75693 | N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)ethanediamide | BRD-K59747209-001-02-6 | HY-76648 | N109 |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | CD4 mimetic (IC50values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell l |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | NBD-556 is small molecule mimetic of CD4, NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | FDA: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | DailyMed: [1] | |
Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | ALA247 | Human immunodeficiency virus type 1 reverse transcriptase | SINGLE PROTEIN | Human immunodeficiency virus 1 | FDA: [1] |
IUPAC Name | N'-(4-chlorophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide |
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INCHI | InChI=1S/C17H24ClN3O2/c1-16(2)9-13(10-17(3,4)21-16)20-15(23)14(22)19-12-7-5-11(18)6-8-12/h5-8,13,21H,9-10H2,1-4H3,(H,19,22)(H,20,23) |
InChi Key | ZKXLQCIOURANAD-UHFFFAOYSA-N |
Canonical SMILES | CC1(CC(CC(N1)(C)C)NC(=O)C(=O)NC2=CC=C(C=C2)Cl)C |
Isomeric SMILES | CC1(CC(CC(N1)(C)C)NC(=O)C(=O)NC2=CC=C(C=C2)Cl)C |
WGK Germany | 3 |
PubChem CID | 1570601 |
Molecular Weight | 337.84 |
Reaxy-Rn | 10573657 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 33.78, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 6.76, Max Conc. mM: 20 |
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Sensitivity | Heat Sensitive |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
Reaxy-Rn | 10573657 |