My Cart
You have no items in your shopping cart.
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
N612175-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,334.90 | |
N612175-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,000.90 |
Synonyms | NBI-34041 | 268545-87-5 | NBI 34041 | 874OEY3JEJ | SB723620 | SB-723620 | 1-(2,4-Dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene | UNII-874OEY3JEJ | CHEMBL188907 | 6H-1,3,6,8a-Tetraazaacenaphthylene, 2-(2,4-dichlorophenyl)-7,8-dihydr |
---|---|
Specifications & Purity | Moligand™ |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of CRF 1 receptor |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|---|---|---|---|---|---|---|
Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | ALA1800 | Corticotropin releasing factor receptor 1 | SINGLE PROTEIN | Homo sapiens | ||
Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | ALA1800 | Corticotropin releasing factor receptor 1 | SINGLE PROTEIN | Homo sapiens | ||
Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | ALA1800 | Corticotropin releasing factor receptor 1 | SINGLE PROTEIN | Homo sapiens | ||
Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | ALA1800 | Corticotropin releasing factor receptor 1 | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | ALA1800 | Corticotropin releasing factor receptor 1 | SINGLE PROTEIN | Homo sapiens |
INCHI | InChI=1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-10-11-28-22-19(27)12-14(3)25-21(22)20(26-28)17-9-8-15(23)13-18(17)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3 |
---|---|
InChi Key | AKLMUGFDGONMAA-UHFFFAOYSA-N |
Canonical SMILES | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC |
Isomeric SMILES | CCCC(CCC)N1CCN2C3=C1C=C(N=C3C(=N2)C4=C(C=C(C=C4)Cl)Cl)C |
PubChem CID | 9888194 |
1. Guo Z, Tellew JE, Gross RS, Dyck B, Grey J, Haddach M, Kiankarimi M, Lanier M, Li BF, Luo Z et al.. (2005) Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.. J Med Chem, 48 (16): (5104-7). [PMID:16078829] [10.1021/op500134e] |
2. Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM, Holsboer F, Grigoriadis DE. (2007) High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response.. Neuropsychopharmacology, 32 (9): (1941-9). [PMID:17287823] [10.1021/op500134e] |