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NBI-34041 , CAS No.268545-87-5, Antagonist of CRF 1 receptor

Item Number
N612175
Grouped product items
SKUSizeAvailabilityPrice Qty
N612175-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
N612175-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

SynonymsNBI-34041 | 268545-87-5 | NBI 34041 | 874OEY3JEJ | SB723620 | SB-723620 | 1-(2,4-Dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene | UNII-874OEY3JEJ | CHEMBL188907 | 6H-1,3,6,8a-Tetraazaacenaphthylene, 2-(2,4-dichlorophenyl)-7,8-dihydr
Specifications & PurityMoligand™
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of CRF 1 receptor

Associated Targets(Human)

CRHR1 Tclin Corticotropin-releasing factor receptor 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Corticotropin releasing factor receptor 1 antagonistANTAGONISTALA1800Corticotropin releasing factor receptor 1SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Corticotropin releasing factor receptor 1 antagonistANTAGONISTALA1800Corticotropin releasing factor receptor 1SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Corticotropin releasing factor receptor 1 antagonistANTAGONISTALA1800Corticotropin releasing factor receptor 1SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Corticotropin releasing factor receptor 1 antagonistANTAGONISTALA1800Corticotropin releasing factor receptor 1SINGLE PROTEINHomo sapiens

PubMed: [1]


Corticotropin releasing factor receptor 1 antagonistANTAGONISTALA1800Corticotropin releasing factor receptor 1SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Names and Identifiers

INCHI InChI=1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-10-11-28-22-19(27)12-14(3)25-21(22)20(26-28)17-9-8-15(23)13-18(17)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3
InChi Key AKLMUGFDGONMAA-UHFFFAOYSA-N
Canonical SMILES CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC
Isomeric SMILES CCCC(CCC)N1CCN2C3=C1C=C(N=C3C(=N2)C4=C(C=C(C=C4)Cl)Cl)C
PubChem CID 9888194

Certificates

C of A & Other Certificates(BSE/TSE, COO)

Related Documents

References

1. Guo Z, Tellew JE, Gross RS, Dyck B, Grey J, Haddach M, Kiankarimi M, Lanier M, Li BF, Luo Z et al..  (2005)  Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists..  J Med Chem,  48  (16): (5104-7).  [PMID:16078829] [10.1021/op500134e]
2. Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM, Holsboer F, Grigoriadis DE.  (2007)  High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response..  Neuropsychopharmacology,  32  (9): (1941-9).  [PMID:17287823] [10.1021/op500134e]

Solution Calculators