(±)-NBI 74330 - ≥96%, high purity , CAS No.473722-68-8, Antagonist of CXCR3

Item Number

N274909

Grouped product items
SKU	Size	Availability	Price
N274909-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90
N274909-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$292.90
N274909-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$658.90
N274909-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,185.90

Potent and selective CXCR3 antagonist

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Basic Description

Synonyms	rac-NBI-74330；racNBI74330；rac NBI 74330；N-[1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide
Specifications & Purity	Moligand™, ≥96%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CXCR3
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	(±)-NBI 74330 is an effective and selective CXCR3 antagonist.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(pyridin-3-ylmethyl)acetamide
INCHI	InChI=1S/C32H27F4N5O3/c1-3-44-24-11-9-23(10-12-24)41-30(39-29-25(31(41)43)7-5-15-38-29)20(2)40(19-22-6-4-14-37-18-22)28(42)17-21-8-13-27(33)26(16-21)32(34,35)36/h4-16,18,20H,3,17,19H2,1-2H3
InChi Key	XMRGQUDUVGRCBS-UHFFFAOYSA-N
Canonical SMILES	CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC(=C(C=C5)F)C(F)(F)F
Isomeric SMILES	CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC(=C(C=C5)F)C(F)(F)F
PubChem CID	10167713
Molecular Weight	605.58

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
B2421646	Certificate of Analysis	Jan 11, 2024	N274909
B2421647	Certificate of Analysis	Jan 11, 2024	N274909
B2421648	Certificate of Analysis	Jan 11, 2024	N274909
B2421653	Certificate of Analysis	Jan 11, 2024	N274909
B2421655	Certificate of Analysis	Jan 11, 2024	N274909
B2421656	Certificate of Analysis	Jan 11, 2024	N274909
B2421657	Certificate of Analysis	Jan 11, 2024	N274909
B2421658	Certificate of Analysis	Jan 11, 2024	N274909

References

1. Heise CE, Pahuja A, Hudson SC, Mistry MS, Putnam AL, Gross MM, Gottlieb PA, Wade WS, Kiankarimi M, Schwarz D et al.. (2005) Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.. J Pharmacol Exp Ther, 313 (3): (1263-71). [PMID:15761110]

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Basic Description