Grouped product items

SKU

Size

Availability

Price

Qty

N338215-100mg

100mg

Available within 8-12 weeks(?)

$762.90

Basic Description

Synonyms	Nebivolol\|99200-09-6\|Narbivolol\|2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)\|(-)-Nebivolol\|(Rac)-Nebivolol\|Vasoxen\|Nobiten\|dl-Nebivolol\|See N387903\|1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor;Antagonist of β 3-adrenoceptor

Associated Targets

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

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CNR1 Tclin Cannabinoid receptor 1 0 Activities

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DRD1 Tclin D(1A) dopamine receptor 0 Activities

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DRD2 Tclin D(2) dopamine receptor 0 Activities

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ESR1 Tclin Estrogen receptor 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AVPR1A Tclin Vasopressin V1a receptor 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

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SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

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CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ADRB3 Tclin Beta-3 adrenergic receptor 0 Activities

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

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EDNRA Tclin Endothelin-1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCND3 Tclin Potassium voltage-gated channel subfamily D member 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MLNR Tchem Motilin receptor 0 Activities

Discover Target: MLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
INCHI	InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
InChi Key	KOHIRBRYDXPAMZ-UHFFFAOYSA-N
Canonical SMILES	C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
Isomeric SMILES	C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
PubChem CID	71301
Molecular Weight	405.44

Database links

DrugBank Ligand	DB04861
PubChem CID	71301
CAS Registry No.	99200-09-6
ChEMBL Ligand	CHEMBL434394
Wikipedia	nebivolol
PEP	nebivolol
Reactome Reaction	R-HSA-9609310
Reactome Drug	R-ALL-9610987
DrugCentral Ligand	1887
GPCRdb Ligand	nebivolol

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Nebivolol - ≥98%, high purity , CAS No.99200-09-6, Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor;Antagonist of β 3-adrenoceptor