Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N125522-10mg | 10mg | In stock | $58.90 | |
N125522-50mg | 50mg | In stock | $177.90 | |
N125522-100mg | 100mg | In stock | $224.90 | |
N125522-250mg | 250mg | In stock | $506.90 | |
N125522-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,822.90 |
Potent, specific necroptosis inhibitor
Synonyms | 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one | 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone | A826160 | HMS3229H21 | CCG-265032 | HY-15760 | Necrostatin 1 | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxoimidazolidin- |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Necrostatin-1(Nec-1) might exhibit therapeutic benefit against patients with traumatic brain injury (TBI). In addition, it might also be used to treat other acute central nervous system (CNS) disorders that feature necroptosis as a mode of cell death. It |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of indoleamine 2;3-dioxygenase 1;Inhibitor of receptor interacting serine/threonine kinase 1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies. |
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IUPAC Name | 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one |
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INCHI | InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
InChi Key | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
Canonical SMILES | CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 |
Isomeric SMILES | CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 |
WGK Germany | 3 |
Alternate CAS | 4311-88-0 |
PubChem CID | 2828334 |
MeSH Entry Terms | Nec-1 compound;necrostatin-1 |
Molecular Weight | 259.33 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2415076 | Certificate of Analysis | Nov 21, 2024 | N125522 |
K2401078 | Certificate of Analysis | Nov 07, 2024 | N125522 |
B2108008 | Certificate of Analysis | Dec 14, 2022 | N125522 |
D2307381 | Certificate of Analysis | Mar 23, 2022 | N125522 |
E2225217 | Certificate of Analysis | Mar 23, 2022 | N125522 |
E2225218 | Certificate of Analysis | Mar 23, 2022 | N125522 |
E2225226 | Certificate of Analysis | Mar 23, 2022 | N125522 |
E2225227 | Certificate of Analysis | Mar 23, 2022 | N125522 |
E2225230 | Certificate of Analysis | Mar 23, 2022 | N125522 |
K2316077 | Certificate of Analysis | Mar 23, 2022 | N125522 |
Solubility | Soluble in DMSO (10-25 mg/ml), 100% ethanol (6 mg/ml), and methanol (5 mg/ml). |
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Sensitivity | Light Sensitive;air sensitive;heat sensitive |
Melt Point(°C) | 160.0 - 164.0 °C |
WGK Germany | 3 |
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1. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao. (2023) Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles. ACS Nano, [PMID:37352508] [10.1021/acsnano.2c12356] |
1. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G et al.. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins.. Nat Chem Biol, 4 (5): (313-21). [PMID:18408713] [10.1021/op500134e] |
2. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.. Nat Chem Biol, 1 (2): (112-9). [PMID:16408008] [10.1021/op500134e] |
3. Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C et al.. (2012) Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.. Cell Death Dis, 3 (13): (e437). [PMID:23190609] [10.1021/op500134e] |
4. Alegre-Cortés E et al.. (2020) Toxicity of Necrostatin-1 in Parkinson's Disease Models.. Antioxidants (Basel), 9 (6): [PMID:32549347] |
5. Li CJ et al.. (2015) \nSynergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.\n. Sci Rep, 5 (9819). [PMID:25909282] |
6. Molnár T et al.. (2021) Caspase-9 acts as a regulator of necroptotic cell death.. FEBS J, 288 (22): (6476-6491). [PMID:33899329] |
7. Tsui KH et al.. (2017) DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells.. Reproduction, 154 (2): (101-110). [PMID:28624766] |
8. Lau H et al.. (2020) Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets.. PLoS One, 15 (12): (e0243506). [PMID:33284818] |
9. Matsuda H et al.. (2017) HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma.. Oncotarget, 8 (41): (69559-69576). [PMID:29050225] |
10. Bockerstett KA et al.. (2018) Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis.. Cell Mol Gastroenterol Hepatol, 5 (4): (678-690.e1). [PMID:29930985] |
11. Dallenga T et al.. (2017) M.\xa0tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages.. Cell Host Microbe, 22 (4): (519-530.e3). [PMID:29024644] |
12. Yan S et al.. (2021) Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells.. Am J Cancer Res, 11 (5): (2062-2080). [PMID:34094669] |
13. Yan B et al.. (2018) Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs.. PLoS One, 13 (11): (e0207760). [PMID:30462730] |
14. Lau H et al.. (2019) Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function.. Xenotransplantation, (e12555). [PMID:31532037] |
15. Lau H et al.. (2021) Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets.. Int J Mol Sci, 22 (16): [PMID:34445075] |
16. Lau H et al.. (2021) The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture.. Xenotransplantation, 28 (3): (e12667). [PMID:33438288] |
17. Trimova G et al.. (2020) Tumour necrosis factor alpha promotes secretion of 14-3-3? by inducing necroptosis in macrophages.. Arthritis Res Ther, 22 (24). [PMID:32051018] |
18. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao. (2023) Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles. ACS Nano, [PMID:37352508] [10.1021/acsnano.2c12356] |