Necrostatin-1 - ≥95%, high purity , CAS No.64419-92-7

  • ≥95%
Item Number
N276209
Grouped product items
SKUSizeAvailabilityPrice Qty
N276209-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$92.90
N276209-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$829.90

Cell-permeable N-demethylated thiohydantoin analog of Necrostatin-1 ( ab141053 ) without antinecroptotic properties

Basic Description

Synonyms64419-92-7 | Nec-1i | Necrostatin-1, Inactive Control | 5-(1H-Indol-3-ylmethyl)-2-thioxo-4-imidazolidinone | 5-((1H-Indol-3-yl)methyl)-2-thioxoimidazolidin-4-one | 5-(Indol-3-ylmethyl)-2-thiohydantoin | 5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one | CHEMBL
Specifications & Purity≥95%
Biochemical and Physiological MechanismsCell-permeable N-demethylated thiohydantoin analog of Necrostatin-1 (Nec-1) without antinecroptotic properties; serves as an inactive control.
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. The product can be stored for up to 12 months.

Associated Targets(Human)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Jurkat (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1548 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one
INCHI InChI=1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)
InChi Key MPLRRPKKFHUEEL-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=CN2)CC3C(=O)NC(=S)N3
Isomeric SMILES C1=CC=C2C(=C1)C(=CN2)CC3C(=O)NC(=S)N3
PubChem CID 5371761
Molecular Weight 245.3

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO

Related Documents

Citations of This Product

1. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao.  (2023)  Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles.  ACS Nano,      [PMID:37352508]

References

1. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao.  (2023)  Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles.  ACS Nano,      [PMID:37352508]

Solution Calculators