Necrosulfonamide - ≥98%, high purity , CAS No.432531-71-0

  • ≥98%
Item Number
N276059
Grouped product items
SKUSizeAvailabilityPrice Qty
N276059-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$156.90
N276059-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$327.90

Potent, selective necroptosis inhibitor. MLKL blocker.

Basic Description

SynonymsNecrosulfonamide | 1360614-48-7 | 432531-71-0 | Necrosulfonamid | (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide | (E/Z)-Necrosulfonamide | (2E)-N-{4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl}-3-(5-nitrothiophen-2-yl)prop-2-ena
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPotent, selective necroptosis inhibitor (IC 50 = 0.2 μM). MLKL blocker. Selectively blocks necrosis downstream of RIP3 activation. Shows selective antinecrotic effects.
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.

Associated Targets(Human)

HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MLKL Tchem Mixed lineage kinase domain-like protein (71 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
INCHI InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+
InChi Key FNPPHVLYVGMZMZ-XBXARRHUSA-N
Canonical SMILES COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]
Isomeric SMILES COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]
PubChem CID 1566236
Molecular Weight 461.47

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 25 mM
Sensitivitylight sensitive

Related Documents

References

1. Murai S et al..  (2018)  A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs..  Nat Commun,  (4457).  [PMID:30367066]
2. Wang Q et al..  (2020)  Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer..  Transl Oncol,  13  (2): (372-382).  [PMID:31887632]
3. André-Grégoire G et al..  (2022)  Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma..  iScience,  25  (10): (105118).  [PMID:36185361]
4. Luo M et al..  (2018)  miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma..  Cell Death Differ,  25  (8): (1457-1472).  [PMID:29348676]
5. Xiao X et al..  (2019)  miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2..  Mol Brain,  12  (78).  [PMID:31533781]
6. Lusthaus M et al..  (2018)  Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity..  Front Immunol,  (306).  [PMID:29527209]
7. Bai T et al..  (2019)  Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells..  J Cell Mol Med,  23  (11): (7349-7359).  [PMID:31507082]
8. Rashidi M et al..  (2019)  The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1ß Release..  J Immunol,  203  (3): (736-748).  [PMID:31209100]

Solution Calculators