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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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N276059-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $156.90 | |
N276059-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $327.90 |
Potent, selective necroptosis inhibitor. MLKL blocker.
Synonyms | Necrosulfonamide | 1360614-48-7 | 432531-71-0 | Necrosulfonamid | (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide | (E/Z)-Necrosulfonamide | (2E)-N-{4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl}-3-(5-nitrothiophen-2-yl)prop-2-ena |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Potent, selective necroptosis inhibitor (IC 50 = 0.2 μM). MLKL blocker. Selectively blocks necrosis downstream of RIP3 activation. Shows selective antinecrotic effects. |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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IUPAC Name | (E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide |
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INCHI | InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+ |
InChi Key | FNPPHVLYVGMZMZ-XBXARRHUSA-N |
Canonical SMILES | COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-] |
Isomeric SMILES | COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-] |
PubChem CID | 1566236 |
Molecular Weight | 461.47 |
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Solubility | Soluble in DMSO to 25 mM |
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Sensitivity | light sensitive |
1. Murai S et al.. (2018) A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs.. Nat Commun, 9 (4457). [PMID:30367066] |
2. Wang Q et al.. (2020) Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer.. Transl Oncol, 13 (2): (372-382). [PMID:31887632] |
3. André-Grégoire G et al.. (2022) Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma.. iScience, 25 (10): (105118). [PMID:36185361] |
4. Luo M et al.. (2018) miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma.. Cell Death Differ, 25 (8): (1457-1472). [PMID:29348676] |
5. Xiao X et al.. (2019) miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2.. Mol Brain, 12 (78). [PMID:31533781] |
6. Lusthaus M et al.. (2018) Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity.. Front Immunol, 9 (306). [PMID:29527209] |
7. Bai T et al.. (2019) Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells.. J Cell Mol Med, 23 (11): (7349-7359). [PMID:31507082] |
8. Rashidi M et al.. (2019) The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1ß Release.. J Immunol, 203 (3): (736-748). [PMID:31209100] |