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Nefazodone Hydrochloride - 98%, high purity , Norepinephrine transporter inhibitor, CAS No.82752-99-6, Norepinephrine transporter inhibitor
Potent 5-HT 2A antagonist
Basic Description Synonyms NEFAZODONE HYDROCHLORIDE|82752-99-6|Nefazodone Hcl|Serzone|Dutonin|Menfazona|Rulivan|Reseril|BMY 13754|Nefazodone (hydrochloride)|1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride|BMY-13754| Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent 5-HT 2A receptor antagonist (K i = 7.1 nM for inhibition of [ 3 H] ketanserin binding in rat cortex). Additionally blocks α 1 adrenoceptors (K i values are 5.5 and 84 nM at α 1 and α 2 , respectively). Shipped In Normal Action Type INHIBITOR Mechanism of action Norepinephrine transporter inhibitor Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Names and Identifiers Pubchem Sid 488183386 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488183386 IUPAC Name 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one;hydrochloride INCHI InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H InChi Key DYCKFEBIOUQECE-UHFFFAOYSA-N Canonical SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl Isomeric SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl WGK Germany 3 PubChem CID 54911 Molecular Weight 506.47
Chemical and Physical Properties Sensitivity Moisture sensitive Melt Point(°C) 188 °C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 Merck Index 6438
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B1914098