Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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N127709-50mg | 50mg | In stock | $561.90 | |
N127709-250mg | 250mg | In stock | $2,529.90 | |
N127709-1g | 1g | In stock | $9,104.90 |
Purine nuceloside analog; inhibits DNA synthesis
Synonyms | Nelarabine | Nelzarabine | 121032-29-9 | Arranon | Atriance | 506U78 | GW-506U78 | 506U | GW 506U78 | Attriance | NSC-686673 | (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine | (2R, |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cellsin vitroandin vivo. |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | DNA inhibitor |
Product Description | Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. Nelarabine (arranon, 506U78) is a purine nucleotide analog, which is an inhibitor of DNA synthesis, with an IC50 of 0.067-2.15 for tumor cells μ M. It can act on T cells and acute lymphoblastic leukemia. |
ALogP | -0.7 |
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IUPAC Name | (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
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INCHI | InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1 |
InChi Key | IXOXBSCIXZEQEQ-UHTZMRCNSA-N |
Canonical SMILES | COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N |
Isomeric SMILES | COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N |
PubChem CID | 3011155 |
Molecular Weight | 297.27 |
DrugBank Ligand | DB01280 |
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PubChem CID | 3011155 |
CAS Registry No. | 121032-29-9 |
ChEMBL Ligand | CHEMBL1201112 |
Wikipedia | Nelarabine |
DrugCentral Ligand | 1892 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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B2316255 | Certificate of Analysis | Aug 11, 2022 | N127709 |
B2316263 | Certificate of Analysis | Aug 11, 2022 | N127709 |
B2316265 | Certificate of Analysis | Aug 11, 2022 | N127709 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 29.73, Max Conc. mM: 100; Solvent:water, Max Conc. mg/mL: 2.97, Max Conc. mM: 10 with gentle warming |
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Sensitivity | light sensitive;Moisture sensitive;heat sensitive |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H351:Suspected of causing cancer H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |