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Nelarabine - ≥98%, high purity , DNA inhibitor, CAS No.121032-29-9, DNA inhibitor

  • Moligand™
  • ≥98%
Item Number
N127709
Grouped product items
SKUSizeAvailabilityPrice Qty
N127709-50mg
50mg
In stock
$561.90
N127709-250mg
250mg
In stock
$2,529.90
N127709-1g
1g
In stock
$9,104.90

Purine nuceloside analog; inhibits DNA synthesis

Basic Description

SynonymsNelarabine|Nelzarabine|121032-29-9|Arranon|Atriance|506U78|GW-506U78|506U|GW 506U78|Attriance|NSC-686673|(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol|2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine|(2R,
Specifications & Purity≥98%
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InDry ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionDNA inhibitor
Product Description

Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

Nelarabine (arranon, 506U78) is a purine nucleotide analog, which is an inhibitor of DNA synthesis, with an IC50 of 0.067-2.15 for tumor cells μ M. It can act on T cells and acute lymphoblastic leukemia.

Product Properties

ALogP-0.7

Names and Identifiers

IUPAC Name (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
INCHI InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
InChi Key IXOXBSCIXZEQEQ-UHTZMRCNSA-N
Canonical SMILES COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N
Isomeric SMILES COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N
PubChem CID 3011155
Molecular Weight 297.27

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
B2316255Certificate of AnalysisAug 11, 2022 N127709
B2316263Certificate of AnalysisAug 11, 2022 N127709
B2316265Certificate of AnalysisAug 11, 2022 N127709

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 29.73, Max Conc. mM: 100; Solvent:water, Max Conc. mg/mL: 2.97, Max Conc. mM: 10 with gentle warming
Sensitivitylight sensitive;Moisture sensitive;heat sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H341:Suspected of causing genetic defects

H351:Suspected of causing cancer

H413:May cause long lasting harmful effects to aquatic life

H302:Harmful if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H361:Suspected of damaging fertility or the unborn child

H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P281:Use personal protective equipment as required.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

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