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Nemadipine A - ≥97%, high purity , CAS No.54280-71-6

  • ≥97%
Item Number
N275975
Grouped product items
SKUSizeAvailabilityPrice Qty
N275975-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$61.90
N275975-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$223.90

Cell-permeable L-type calcium channel protein inhibitor

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Basic Description

Specifications & Purity≥97%
Biochemical and Physiological MechanismsCell-permeable L-type calcium channel protein inhibitor. Antagonizes α1-subunit of L-type calcium channel. Sensitizes cancer cells to TRAIL-induced apoptosis. 1,4-dihydropyridine (DHP) analog.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Dopamine D1 receptor agonistAGONISTALA2056Dopamine D1 receptorSINGLE PROTEINHomo sapiens

DailyMed: [1]


Dopamine D1 receptor antagonistANTAGONISTALA2056Dopamine D1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Wikipedia: [1]


Dopamine D1 receptor antagonistANTAGONISTALA2056Dopamine D1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Dopamine D1 receptor partial agonistPARTIAL AGONISTALA2056Dopamine D1 receptorSINGLE PROTEINHomo sapiens

Other: [1] , [2]


Dopamine D1 receptor positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORALA2056Dopamine D1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Serine/threonine-protein kinase mTOR inhibitorINHIBITORALA2842Serine/threonine-protein kinase mTORSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase mTOR inhibitorINHIBITORALA2842Serine/threonine-protein kinase mTORSINGLE PROTEINHomo sapiens

PubMed: [1]


Serine/threonine-protein kinase mTOR inhibitorINHIBITORALA2842Serine/threonine-protein kinase mTORSINGLE PROTEINHomo sapiens

PubMed: [1]


Serine/threonine-protein kinase mTOR inhibitorINHIBITORALA2842Serine/threonine-protein kinase mTORSINGLE PROTEINHomo sapiens

DOI: [1]


Other: [1]


Serine/threonine-protein kinase mTOR inhibitorINHIBITORALA2842Serine/threonine-protein kinase mTORSINGLE PROTEINHomo sapiens

PubMed: [1]


Names and Identifiers

IUPAC Name diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INCHI InChI=1S/C19H18F5NO4/c1-5-28-18(26)9-7(3)25-8(4)10(19(27)29-6-2)11(9)12-13(20)15(22)17(24)16(23)14(12)21/h11,25H,5-6H2,1-4H3
InChi Key QABNLWXKUCMDBP-UHFFFAOYSA-N
Canonical SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C
Isomeric SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C
PubChem CID 2856102
Molecular Weight 419.34

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
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Chemical and Physical Properties

SolubilitySoluble in ethanol to 25 mM and in DMSO to 25 mM

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

References

1. Gao L et al..  (2022)  Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains..  Elife,  11    [PMID:35266450]

Solution Calculators