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Nemadipine A - ≥97%, high purity , CAS No.54280-71-6
Cell-permeable L-type calcium channel protein inhibitor
Basic Description Synonyms Nemadipine-A | 54280-71-6 | nemadipine A | diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | CHEBI:78546 | 1,4-Dihydro-2,6-dimethyl-4-(pentafluorophenyl)-3,5-pyridinedicarboxylic acid diethyl ester | diethyl 2,6-dimethyl- Specifications & Purity ≥97% Biochemical and Physiological Mechanisms Cell-permeable L-type calcium channel protein inhibitor. Antagonizes α1-subunit of L-type calcium channel. Sensitizes cancer cells to TRAIL-induced apoptosis. 1,4-dihydropyridine (DHP) analog. Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate INCHI InChI=1S/C19H18F5NO4/c1-5-28-18(26)9-7(3)25-8(4)10(19(27)29-6-2)11(9)12-13(20)15(22)17(24)16(23)14(12)21/h11,25H,5-6H2,1-4H3 InChi Key QABNLWXKUCMDBP-UHFFFAOYSA-N Canonical SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C Isomeric SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C PubChem CID 2856102 Molecular Weight 419.34
Chemical and Physical Properties Solubility Soluble in ethanol to 25 mM and in DMSO to 25 mM
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Gao L et al.. (2022) Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains.. Elife, 11 [PMID:35266450 ]
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