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Nemolizumab (anti-IL-31Ra) (Ab170532) - SEC
The purity of Nemolizumab (anti-IL-31Ra) (Ab170532) is more than 95% verified by HPLC.
SKU | Size | Availability | Price | Qty |
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Ab170532-100μg | 100μg | In stock | $39.90 | |
Ab170532-1mg | 1mg | In stock | $177.90 | |
Ab170532-5mg | 5mg | In stock | $447.90 | |
Ab170532-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $747.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Product Name | Nemolizumab (anti-IL-31Ra) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL31RA, >95%, high purity, Human IgG2 |
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Synonyms | Cytokine receptor-like 3 | GLM-R | Gp130-like monocyte receptor | Gp130-like receptor | hGLM-R | IL-31 receptor subunit alpha | IL-31R subunit alpha | IL-31RA | IL-31R-alpha | ZcytoR17 |
Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
Host species | Human |
Specificity | IL31RA |
Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
Conjugation | Unconjugated |
Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
Action Type | INHIBITOR |
Mechanism of action | Antibody of Interleukin-31 receptor; α subunit |
Product Description | Nemolizumab (anti-IL-31Ra) is a humanized antihuman interleukin-31 receptor A monoclonal antibody that inhibits the binding of interleukin-31 (IL-31) to its receptor and subsequent signal transduction. Nemolizumab can used be in research of atopic dermatitis (AD). |
Antibody Type | Primary antibody |
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Clonality | Recombinant |
Isotype | Human IgG2 |
Light Chain Type | kappa |
SDS-PAGE | 26.5 kDa (Light Chain) & 54.0 kDa (Heavy Chain), under reducing conditions; 175.4 kDa, under non-reducing conditions. |
Purification Method | Protein A purified |
Purity | >95% |
Source | CHO supernatant |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
CAS | 1476039-58-3 |
Nemolizumab (anti-IL-31Ra) (Ab170532) - SEC
The purity of Nemolizumab (anti-IL-31Ra) (Ab170532) is more than 95% verified by HPLC.
Nemolizumab (anti-IL-31Ra) (Ab170532) - ELISA
Immobilized Human IL-31RA - Fc tag at 2 μg/mL can bind Nemolizumab (anti-IL-31Ra) (Ab170532) with the EC₅₀ of 20.79 ng/mL.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IMGT/mAb-DB | 538 |
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Application | Dilution info |
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IF/ICC |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
ZJ24F0303672 | Certificate of Analysis | Mar 25, 2024 | Ab170532 |
ZJ24F0303671 | Certificate of Analysis | Mar 25, 2024 | Ab170532 |
ZJ24F0303670 | Certificate of Analysis | Mar 25, 2024 | Ab170532 |
1. Kasutani K, Fujii E, Ohyama S, Adachi H, Hasegawa M, Kitamura H, Yamashita N. (2014) Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice.. Br J Pharmacol, 171 (22): (5049-58). [PMID:24946165] [10.1021/op500134e] |
2. Kabashima K, Matsumura T, Komazaki H, Kawashima M, Nemolizumab-JP01 Study Group. (2020) Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus.. N Engl J Med, 383 (2): (141-150). [PMID:32640132] [10.1021/op500134e] |
3. Kabashima K, Furue M, Hanifin JM, Pulka G, Wollenberg A, Galus R, Etoh T, Mihara R, Nakano M, Ruzicka T. (2018) Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study.. J Allergy Clin Immunol, 142 (4): (1121-1130.e7). [PMID:29753033] [10.1021/op500134e] |
4. Nemoto O, Furue M, Nakagawa H, Shiramoto M, Hanada R, Matsuki S, Imayama S, Kato M, Hasebe I, Taira K et al.. (2016) The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study.. Br J Dermatol, 174 (2): (296-304). [PMID:26409172] [10.1021/op500134e] |
5. Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J et al.. (2004) Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.. Nat Immunol, 5 (7): (752-60). [PMID:15184896] [10.1021/op500134e] |
6. Ghilardi, Nico N and 5 more authors.. (2002) A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.. The Journal of biological chemistry, (10): [PMID:11877449] |
7. Diveu, Caroline C and 14 more authors.. (2003) GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor.. The Journal of biological chemistry, (12): [PMID:14504285] |
8. Dreuw, Alexandra A and 5 more authors.. (2004) Characterization of the signaling capacities of the novel gp130-like cytokine receptor.. The Journal of biological chemistry, (20): [PMID:15194700] |
9. Diveu, Caroline C and 8 more authors.. () Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling.. European cytokine network, [PMID:15627637] |
10. Bilsborough, Janine J and 10 more authors.. (2006) IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis.. The Journal of allergy and clinical immunology, [PMID:16461143] |
11. Jawa, Randeep S RS and 6 more authors.. (2008) Regulated expression of the IL-31 receptor in bronchial and alveolar epithelial cells, pulmonary fibroblasts, and pulmonary macrophages.. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, [PMID:18439099] |
12. Lin, Ming-Wei MW and 16 more authors.. (2010) Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis.. European journal of human genetics : EJHG, [PMID:19690585] |
13. Kasraie, Sadaf S, Niebuhr, M M, Baumert, K K and Werfel, T T.. (2011) Functional effects of interleukin 31 in human primary keratinocytes.. Allergy, [PMID:21261663] |
14. Cevikbas, Ferda F and 17 more authors.. (2014) A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.. The Journal of allergy and clinical immunology, [PMID:24373353] |