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Neohesperidin - 97%, high purity , CAS No.13241-33-3

8 Citations
  • ≥97%
Item Number
N140716
Grouped product items
SKUSizeAvailabilityPrice Qty
N140716-100mg
100mg
In stock
$46.90
N140716-500mg
500mg
In stock
$179.90
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Antioxidant agent

View related series
Disaccharide Six-Membered Heterocyclic Compounds

Basic Description

Synonyms(S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one | 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deox
Specifications & Purity≥97%
Biochemical and Physiological MechanismsAntioxidant agent. Precursor of neohesperidin dihydrochalcone . Regulates apoptotic activity. Inhibits proliferation (IC 50 = 47 μm). Scavenges ROS. Shows anti-ischemic effects in vivo. Orally active.
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Neohesperidin is a flavonoid. Flavanone glycoside with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model .
An antioxidant flavanone glycoside

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BCHE Tclin Cholinesterase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Monocyte (474 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
INCHI InChI=1S/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
InChi Key ARGKVCXINMKCAZ-UZRWAPQLSA-N
Canonical SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O
WGK Germany 3
RTECS DJ2981400
PubChem CID 442439
Molecular Weight 610.56
Beilstein 74945

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
G2431390Certificate of AnalysisAug 05, 2024 N140716
G2431392Certificate of AnalysisAug 05, 2024 N140716
D1608096Certificate of AnalysisDec 19, 2023 N140716

Chemical and Physical Properties

Sensitivitylight sensitive
Specific Rotation[α]-97° (C=1,Pyridine)
Melt Point(°C)243 °C

Safety and Hazards(GHS)

WGK Germany 3
RTECS DJ2981400

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting.  (2022)  Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling.  AMB Express,  12  (1): (1-14).  [PMID:36370155] [10.1186/s13568-022-01489-5]
2. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang.  (2023)  Municipal green waste promotes iron release from steelmaking slag in water.  RESOURCES CONSERVATION AND RECYCLING,  188  (106722).  [PMID:] [10.1016/j.resconrec.2022.106722]
3. Qi Quan, Wei Liu, Jiajing Guo, Meiling Ye, Juhua Zhang.  (2022)  Effect of Six Lactic Acid Bacteria Strains on Physicochemical Characteristics, Antioxidant Activities and Sensory Properties of Fermented Orange Juices.  Foods,  11  (13): (1920).  [PMID:35804736] [10.3390/foods11131920]
4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
5. Lu Shao Hua, Zhang Ming Cai, Zhai Hong Lin, Bi Ke Xin, Zhao Bing Qiang.  (2022)  Rapid Determination in the Quality Control of Chinese Patent Medicine.  Journal of Pharmaceutical Innovation,  17  (4): (1305-1313).  [PMID:] [10.1007/s12247-021-09608-8]
6. Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang.  (2021)  Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities.  LWT-FOOD SCIENCE AND TECHNOLOGY,  147  (111671).  [PMID:] [10.1016/j.lwt.2021.111671]
7. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277] [10.1016/j.saa.2020.118519]
8. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646] [10.1016/j.foodchem.2020.126807]

References

1. Agata Zygler,Andrzej Wasik,Agata Kot-Wasik,Jacek Namieśnik.  (2011-04-06)  Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection..  Analytical and bioanalytical chemistry,  400  ((7)): (2159-2172).  [PMID:21465096]
2. Adriana C E Graziano,Venera Cardile,Lucia Crascì,Sivia Caggia,Paola Dugo,Francesco Bonina,Annamaria Panico.  (2012-05-29)  Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-γ and histamine exposed human keratinocytes..  Life sciences,  90  ((25-26)): (968-974).  [PMID:22634580]
3. Yonathan Asikin,Ikuko Taira,Sayuri Inafuku-Teramoto,Hidekazu Sumi,Hideaki Ohta,Kensaku Takara,Koji Wada.  (2012-07-19)  The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines..  Journal of agricultural and food chemistry,  60  ((32)): (7973-7980).  [PMID:22804782]
4. Wanpeng Xi,Bo Fang,Qiyang Zhao,Bining Jiao,Zhiqin Zhou.  (2014-05-20)  Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties..  Food chemistry,  161  (230-238).  [PMID:24837945]
5. Su-Chen Ho,Chun-Ting Kuo.  (2014-06-24)  Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  71  (176-182).  [PMID:24955543]
6. Chung-Hsi Chou,Cheng-Wei Liu,Deng-Jye Yang,Yi-Hsieng Samuel Wu,Yi-Chen Chen.  (2014-08-31)  Amino acid, mineral, and polyphenolic profiles of black vinegar, and its lipid lowering and antioxidant effects in vivo..  Food chemistry,  168  (63-69).  [PMID:25172684]
7. Paweł Kubica,Jacek Namieśnik,Andrzej Wasik.  (2014-12-05)  Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry..  Analytical and bioanalytical chemistry,  407  ((5)): (1505-1512).  [PMID:25471292]
8. Feng-Quan Tan,Hong Tu,Wu-Jun Liang,Jian-Mei Long,Xiao-Meng Wu,Hong-Yan Zhang,Wen-Wu Guo.  (2015-04-08)  Comparative metabolic and transcriptional analysis of a doubled diploid and its diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) suggests its potential value for stress resistance improvement..  BMC plant biology,  15  (89-89).  [PMID:25848687]
9. Linlin Chang,Sheng Jia,Yingying Fu,Tianyi Zhou,Ji Cao,Qiaojun He,Bo Yang,Xian Li,Chongde Sun,Dan Su,Hong Zhu,Kunsong Chen.  (2015-07-02)  Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells..  Chinese medicine,  10  (14-14).  [PMID:26131016]
10. Nurcan Değirmencioğlu,Ozan Gürbüz,Emine Nur Herken,Aysun Yurdunuseven Yıldız.  (2015-10-17)  The impact of drying techniques on phenolic compound, total phenolic content and antioxidant capacity of oat flour tarhana..  Food chemistry,  194  (587-594).  [PMID:26471596]
11. B Aydeniz Güneşer,E Yilmaz.  (2019-03-25)  Comparing the effects of conventional and microwave roasting methods for bioactive composition and the sensory quality of cold-pressed orange seed oil..  Journal of food science and technology,  56  ((2)): (634-642).  [PMID:30906021]
12. Sylwia Magiera,Irena Baranowska,Anna Lautenszleger.  (2014-12-03)  UHPLC-UV method for the determination of flavonoids in dietary supplements and for evaluation of their antioxidant activities..  Journal of pharmaceutical and biomedical analysis,  102  (468-475).  [PMID:25459947]
13. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting.  (2022)  Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling.  AMB Express,  12  (1): (1-14).  [PMID:36370155] [10.1186/s13568-022-01489-5]
14. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang.  (2023)  Municipal green waste promotes iron release from steelmaking slag in water.  RESOURCES CONSERVATION AND RECYCLING,  188  (106722).  [PMID:] [10.1016/j.resconrec.2022.106722]
15. Qi Quan, Wei Liu, Jiajing Guo, Meiling Ye, Juhua Zhang.  (2022)  Effect of Six Lactic Acid Bacteria Strains on Physicochemical Characteristics, Antioxidant Activities and Sensory Properties of Fermented Orange Juices.  Foods,  11  (13): (1920).  [PMID:35804736] [10.3390/foods11131920]
16. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
17. Lu Shao Hua, Zhang Ming Cai, Zhai Hong Lin, Bi Ke Xin, Zhao Bing Qiang.  (2022)  Rapid Determination in the Quality Control of Chinese Patent Medicine.  Journal of Pharmaceutical Innovation,  17  (4): (1305-1313).  [PMID:] [10.1007/s12247-021-09608-8]
18. Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang.  (2021)  Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities.  LWT-FOOD SCIENCE AND TECHNOLOGY,  147  (111671).  [PMID:] [10.1016/j.lwt.2021.111671]
19. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277] [10.1016/j.saa.2020.118519]
20. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646] [10.1016/j.foodchem.2020.126807]

Solution Calculators

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