Neohesperidin dihydrochalcone - ≥98.0%(T), high purity , CAS No.20702-77-6

  • ≥98%(T)
Item Number
N111097
Grouped product items
SKUSizeAvailabilityPrice Qty
N111097-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$88.90
N111097-5g
5g
In stock
$117.90
N111097-25g
25g
In stock
$531.90
N111097-100g
100g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,911.90

Basic Description

Synonyms3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | 1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-
Specifications & Purity≥98%(T)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS1R3 Tbio T1R1/T1R3 (473 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
INCHI InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
InChi Key ITVGXXMINPYUHD-CUVHLRMHSA-N
Canonical SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O
WGK Germany 3
RTECS LZ5785000
PubChem CID 30231
Molecular Weight 612.58
Reaxy-Rn 4285336

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
D1725048Certificate of AnalysisNov 14, 2024 N111097

Chemical and Physical Properties

Melt Point(°C)156-158°C

Safety and Hazards(GHS)

WGK Germany 3
RTECS LZ5785000
Reaxy-Rn 4285336
Merck Index 6452

Related Documents

Citations of This Product

1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (17): (101023).  [PMID:38144792] [10.1016/j.fochx.2023.101023]
2. Caiying Zhang, Yuelong Li, Abdus Samad, Hongliang He, Huan Ma, Yang Chen, Tengchuan Jin.  (2024)  Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127856).  [PMID:37924898] [10.1016/j.ijbiomac.2023.127856]
3. Liang Zhang, Junhui Xu, Jing Qian, Yazhen Wang.  (2023)  A novel detection method for neohesperidin dihydrochalcone (NHDC) based on ZIF-8/ErGO composite modified electrode in milk.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  123  (105584).  [PMID:] [10.1016/j.jfca.2023.105584]
4. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
5. Xiaomin Xia, Juanli Fu, Xiufang Song, Qiong Shi, Chuanyang Su, Erqun Song, Yang Song.  (2015)  Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.  FREE RADICAL BIOLOGY AND MEDICINE,  89  (522).  [PMID:26453923] [10.1016/j.freeradbiomed.2015.08.023]
6. Qiong Shi, Xiufang Song, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song.  (2015)  Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.  INTERNATIONAL IMMUNOPHARMACOLOGY,  29  (722).  [PMID:26362205] [10.1016/j.intimp.2015.09.003]
7. Chuanyang Su, Xiaomin Xia, Qiong Shi, Xiufang Song, Juanli Fu, Congxue Xiao, Hongjun Chen, Bin Lu, Zhiyin Sun, Shanmei Wu, Siyu Yang, Xuegang Li, Xiaoli Ye, Erqun Song, Yang Song.  (2015)  Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  63  (22): (5468–5475).  [PMID:25978654] [10.1021/acs.jafc.5b01750]
8. Lingxi Yang, Lu Wang, Kunjing Li, Baoxian Ye.  (2014)  Sensitive voltammetric determination of neohesperidin dihydrochalcone based on SWNTs modified glassy carbon electrode.  Analytical Methods,  (23): (9410-9418).  [PMID:] [10.1039/C4AY02004A]

References

1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (17): (101023).  [PMID:38144792] [10.1016/j.fochx.2023.101023]
2. Caiying Zhang, Yuelong Li, Abdus Samad, Hongliang He, Huan Ma, Yang Chen, Tengchuan Jin.  (2024)  Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127856).  [PMID:37924898] [10.1016/j.ijbiomac.2023.127856]
3. Liang Zhang, Junhui Xu, Jing Qian, Yazhen Wang.  (2023)  A novel detection method for neohesperidin dihydrochalcone (NHDC) based on ZIF-8/ErGO composite modified electrode in milk.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  123  (105584).  [PMID:] [10.1016/j.jfca.2023.105584]
4. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
5. Xiaomin Xia, Juanli Fu, Xiufang Song, Qiong Shi, Chuanyang Su, Erqun Song, Yang Song.  (2015)  Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.  FREE RADICAL BIOLOGY AND MEDICINE,  89  (522).  [PMID:26453923] [10.1016/j.freeradbiomed.2015.08.023]
6. Qiong Shi, Xiufang Song, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song.  (2015)  Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.  INTERNATIONAL IMMUNOPHARMACOLOGY,  29  (722).  [PMID:26362205] [10.1016/j.intimp.2015.09.003]
7. Chuanyang Su, Xiaomin Xia, Qiong Shi, Xiufang Song, Juanli Fu, Congxue Xiao, Hongjun Chen, Bin Lu, Zhiyin Sun, Shanmei Wu, Siyu Yang, Xuegang Li, Xiaoli Ye, Erqun Song, Yang Song.  (2015)  Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  63  (22): (5468–5475).  [PMID:25978654] [10.1021/acs.jafc.5b01750]
8. Lingxi Yang, Lu Wang, Kunjing Li, Baoxian Ye.  (2014)  Sensitive voltammetric determination of neohesperidin dihydrochalcone based on SWNTs modified glassy carbon electrode.  Analytical Methods,  (23): (9410-9418).  [PMID:] [10.1039/C4AY02004A]

Solution Calculators