Nepafenac - 10mM in DMSO, high purity , CAS No.78281-72-8

Item Number
N425941
Grouped product items
SKUSizeAvailabilityPrice Qty
N425941-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$241.90

Basic Description

SynonymsNepafenac | 78281-72-8 | Nevanac | 2-(2-Amino-3-benzoylphenyl)acetamide | 2-Amino-3-benzoylbenzeneacetamide | Ilevro | AHR-9434 | AL 6515 | AL-6515 | AHR 9434 | Benzeneacetamide, 2-amino-3-benzoyl- | nepafenaco | nepafenacum | CHEBI:75922 | UNII-0J9L7J6V8C | 0J9L7J6V8C | DTXSID0048638 | D
Specifications & PurityMoligand™, 10mM in DMSO
Biochemical and Physiological MechanismsNepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery. Nepafenac is a selective COX-2 inhibitor. Nepafenac is prodrug of Amfenac.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

An analgesic selective inhibitor of COX-2

Product Properties

ALogP1.9

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS1 Tclin Prostaglandin G/H synthase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase (1258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-(2-amino-3-benzoylphenyl)acetamide
INCHI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChi Key QEFAQIPZVLVERP-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Isomeric SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
WGK Germany 3
PubChem CID 151075
Molecular Weight 254.28

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SensitivityHeat sensitive
Melt Point(°C)184 °C

Safety and Hazards(GHS)

Pictogram(s) GHS09
Signal Warning
Hazard Statements

H400:Very toxic to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P391:Collect spillage.

WGK Germany 3
Merck Index 6469

Related Documents

Solution Calculators