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Nepicastat (SYN-117) HCl - 10mM in DMSO, high purity , CAS No.170151-24-3(DMSO)
Potent and selective dopamine β-hydroxylase (DBH) inhibitor
Basic Description Synonyms Nepicastat hydrochloride | 170151-24-3 | Nepicastat HCl | (S)-5-(aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride | Nepicastat hydrochloride anhydrous | Nepicastat (SYN-117) HCl | Nepicastat (hydrochloride) | Nepic Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent and selective dopamineβ-hydroxylase (DBH) inhibitor (IC50= 9 nM). Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfu Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione;hydrochloride INCHI InChI=1S/C14H15F2N3S.ClH/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20;/h3,5,7,10H,1-2,4,6,17H2,(H,18,20);1H/t10-;/m0./s1 InChi Key DIPDUAJWNBEVOY-PPHPATTJSA-N Canonical SMILES C1CC2=C(CC1N3C(=CNC3=S)CN)C=C(C=C2F)F.Cl Isomeric SMILES C1CC2=C(C[C@H]1N3C(=CNC3=S)CN)C=C(C=C2F)F.Cl WGK Germany 3 PubChem CID 9840545 Molecular Weight 331.81
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 33.18, Max Conc. mM: 100 Sensitivity Moisture sensitive
Safety and Hazards(GHS) Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
WGK Germany 3
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