Neurotensin - 97%, high purity , CAS No.55508-42-4, Agonist of NTS 1 receptor;Agonist of NTS 2 receptor

Item Number
N274706
Grouped product items
SKUSizeAvailabilityPrice Qty
N274706-1mg
1mg
In stock
$57.90
N274706-5mg
5mg
In stock
$256.90
N274706-10mg
10mg
In stock
$461.90
N274706-25mg
25mg
In stock
$1,038.90
N274706-50mg
50mg
In stock
$1,869.90
N274706-100mg
100mg
In stock
$3,365.90
N274706-200mg
200mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$6,058.90

Endogenous neuropeptide and endocrine modulator

Basic Description

SynonymsH-Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH | GTPL1579 | L-pyroglutamyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparagyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Ty
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsEndogenous neuropeptide and endocrine modulator. Elicits a variery of central and peripheral functions, including neurological, digestive and cardiovascular modulation. Capable of non-selective activation of neurotensin receptors
Storage TempStore at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of NTS 1 receptor;Agonist of NTS 2 receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Sequence Shortening:Pyr-LYENKPRRPYIL

Sequence:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu;


Associated Targets(Human)

NTSR1 Tchem Neurotensin receptor type 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTSR2 Tchem Neurotensin receptor type 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTSR2 Tchem Neurotensin receptor 2 (296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SORT1 Tchem Neurotensin receptor 3 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
INCHI InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
InChi Key PCJGZPGTCUMMOT-ISULXFBGSA-N
Canonical SMILES CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(C)C)NC(=O)C5CCC(=O)N5
Isomeric SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5
Alternate CAS 39379-15-2
PubChem CID 25077406
Molecular Weight 1672.94

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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14 results found

Lot NumberCertificate TypeDateItem
G2429033Certificate of AnalysisAug 05, 2024 N274706
F2316779Certificate of AnalysisMay 10, 2024 N274706
F2316775Certificate of AnalysisMay 10, 2024 N274706
F2316769Certificate of AnalysisMay 10, 2024 N274706
F2316750Certificate of AnalysisMay 10, 2024 N274706
F2316734Certificate of AnalysisMay 10, 2024 N274706
F2316780Certificate of AnalysisApr 11, 2024 N274706
F2316766Certificate of AnalysisMar 20, 2024 N274706
F2316768Certificate of AnalysisMar 20, 2024 N274706
F2316774Certificate of AnalysisMar 20, 2024 N274706
F2316777Certificate of AnalysisMar 20, 2024 N274706
F2316790Certificate of AnalysisMar 20, 2024 N274706
F2316797Certificate of AnalysisMar 20, 2024 N274706
F2316803Certificate of AnalysisMar 20, 2024 N274706

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Chemical and Physical Properties

SolubilitySoluble in water
SensitivityMoisture sensitive

Related Documents

Citations of This Product

1. Hongfei Li, Ji-Hong Chen, Zixian Yang, Min Huang, Yuanjie Yu, Shiyun Tan, Hesheng Luo, Jan D Huizinga.  (2016)  Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon.  Journal of Neurogastroenterology and Motility,  22  (3): ( 517–528).  [PMID:26882114] [10.5056/jnm15181]
2. Guihua Ruan, Zhengyi Chen, Meiping Wei, Yuhua Liu, Haiyun Li, Fuyou Du.  (2013)  The study on microwave assisted enzymatic digestion of ginkgo protein.  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,  94  (23).  [PMID:] [10.1016/j.molcatb.2013.04.010]

References

1. Umezu K et al..  (2019)  Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during in vitro fertilization..  J Reprod Dev,      [PMID:30662011]
2. Hongfei Li, Ji-Hong Chen, Zixian Yang, Min Huang, Yuanjie Yu, Shiyun Tan, Hesheng Luo, Jan D Huizinga.  (2016)  Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon.  Journal of Neurogastroenterology and Motility,  22  (3): ( 517–528).  [PMID:26882114] [10.5056/jnm15181]
3. Guihua Ruan, Zhengyi Chen, Meiping Wei, Yuhua Liu, Haiyun Li, Fuyou Du.  (2013)  The study on microwave assisted enzymatic digestion of ginkgo protein.  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,  94  (23).  [PMID:] [10.1016/j.molcatb.2013.04.010]

Solution Calculators