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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N274706-1mg | 1mg | In stock | $57.90 | |
N274706-5mg | 5mg | In stock | $256.90 | |
N274706-10mg | 10mg | In stock | $461.90 | |
N274706-25mg | 25mg | In stock | $1,038.90 | |
N274706-50mg | 50mg | In stock | $1,869.90 | |
N274706-100mg | 100mg | In stock | $3,365.90 | |
N274706-200mg | 200mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $6,058.90 |
Endogenous neuropeptide and endocrine modulator
Synonyms | H-Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH | GTPL1579 | L-pyroglutamyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparagyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Ty |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Endogenous neuropeptide and endocrine modulator. Elicits a variery of central and peripheral functions, including neurological, digestive and cardiovascular modulation. Capable of non-selective activation of neurotensin receptors |
Storage Temp | Store at -20°C,Argon charged,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of NTS 1 receptor;Agonist of NTS 2 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. Sequence Shortening:Pyr-LYENKPRRPYIL Sequence:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu; |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
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INCHI | InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 |
InChi Key | PCJGZPGTCUMMOT-ISULXFBGSA-N |
Canonical SMILES | CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(C)C)NC(=O)C5CCC(=O)N5 |
Isomeric SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5 |
Alternate CAS | 39379-15-2 |
PubChem CID | 25077406 |
Molecular Weight | 1672.94 |
UniProtKB | P30990, Q9D3P9, P20068, P01156 |
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PubChem CID | 25077406 |
CAS Registry No. | 55508-42-4 |
Wikipedia | Neurotensin |
ChEMBL Ligand | CHEMBL407196 |
PEP | neurotensin |
Ensembl Gene | ENSBTAG00000005305, ENSG00000133636 |
GPCRdb Ligand | neurotensin |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2429033 | Certificate of Analysis | Aug 05, 2024 | N274706 |
F2316779 | Certificate of Analysis | May 10, 2024 | N274706 |
F2316775 | Certificate of Analysis | May 10, 2024 | N274706 |
F2316769 | Certificate of Analysis | May 10, 2024 | N274706 |
F2316750 | Certificate of Analysis | May 10, 2024 | N274706 |
F2316734 | Certificate of Analysis | May 10, 2024 | N274706 |
F2316780 | Certificate of Analysis | Apr 11, 2024 | N274706 |
F2316766 | Certificate of Analysis | Mar 20, 2024 | N274706 |
F2316768 | Certificate of Analysis | Mar 20, 2024 | N274706 |
F2316774 | Certificate of Analysis | Mar 20, 2024 | N274706 |
F2316777 | Certificate of Analysis | Mar 20, 2024 | N274706 |
F2316790 | Certificate of Analysis | Mar 20, 2024 | N274706 |
F2316797 | Certificate of Analysis | Mar 20, 2024 | N274706 |
F2316803 | Certificate of Analysis | Mar 20, 2024 | N274706 |
Solubility | Soluble in water |
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Sensitivity | Moisture sensitive |
1. Hongfei Li, Ji-Hong Chen, Zixian Yang, Min Huang, Yuanjie Yu, Shiyun Tan, Hesheng Luo, Jan D Huizinga. (2016) Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon. Journal of Neurogastroenterology and Motility, 22 (3): ( 517–528). [PMID:26882114] [10.5056/jnm15181] |
2. Guihua Ruan, Zhengyi Chen, Meiping Wei, Yuhua Liu, Haiyun Li, Fuyou Du. (2013) The study on microwave assisted enzymatic digestion of ginkgo protein. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 94 (23). [PMID:] [10.1016/j.molcatb.2013.04.010] |
1. Umezu K et al.. (2019) Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during in vitro fertilization.. J Reprod Dev, [PMID:30662011] |
2. Hongfei Li, Ji-Hong Chen, Zixian Yang, Min Huang, Yuanjie Yu, Shiyun Tan, Hesheng Luo, Jan D Huizinga. (2016) Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon. Journal of Neurogastroenterology and Motility, 22 (3): ( 517–528). [PMID:26882114] [10.5056/jnm15181] |
3. Guihua Ruan, Zhengyi Chen, Meiping Wei, Yuhua Liu, Haiyun Li, Fuyou Du. (2013) The study on microwave assisted enzymatic digestion of ginkgo protein. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 94 (23). [PMID:] [10.1016/j.molcatb.2013.04.010] |