Nevadensin - 99%, high purity , CAS No.10176-66-6

Item Number

N647433

Grouped product items
SKU	Size	Availability	Price
N647433-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$50.90
N647433-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
N647433-20mg	20mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$140.90

Flavonoids Flavones Phenols Polyphenols

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Basic Description

Synonyms	4H-1-Benzopyran-4-one, 5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)- \| HY-N1377 \| Lysionatin \| DTXSID40144174 \| PS-3199 \| 5,7-Dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one \| 5,7-hydroxy-4',6,8-trimethoxyflavone \| CCG-267965 \| 5,7-di
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC 50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Product Description	Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC 50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive Form:Solid IC50& Target:IC50: 2.64 μM (hCE1), 132.8 μM (hCE2)

Associated Targets(Human)

AKR1B1 Tclin Aldose reductase (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NQO1 Tchem NAD(P)H dehydrogenase [quinone] 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase (1404 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NQO1 Tchem Quinone reductase 1 (1746 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Panel NCI-60 (60 carcinoma cell lines) (1088 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
INCHI	InChI=1S/C18H16O7/c1-22-10-6-4-9(5-7-10)12-8-11(19)13-14(20)17(23-2)15(21)18(24-3)16(13)25-12/h4-8,20-21H,1-3H3
InChi Key	KRFBMPVGAYGGJE-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)O)OC)O
Isomeric SMILES	COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)O)OC)O
PubChem CID	160921
Molecular Weight	344.32

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Basic Description