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Nexturastat A - 98%, high purity , CAS No.1403783-31-2, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 6

Moligand™
≥98%

CAS#: 1403783-31-2
Formula: C₁₉H₂₃N₃O₃
Molecular Weight: 341.4
PubChem CID: 71462653

Item Number

N349054

Grouped product items
SKU	Size	Availability	Price
N349054-1mg	1mg	In stock	$77.90
N349054-5mg	5mg	In stock	$116.90
N349054-25mg	25mg	In stock	$526.90
N349054-100mg	100mg	In stock	$597.90

View related series

histone deacetylase 1 Inhibitor histone deacetylase 6 Inhibitor

Basic Description

Synonyms	Nexturastat A\|1403783-31-2\|4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide\|Nexturastata\|s7473\|CHEMBL2179618\|4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide\|4-{[butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide\|Benzamide, 4-[[butyl[(p
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 6
Product Description	Product Describtion: Nexturastat A is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 value of 5 nM. Product Application： In B16 murine melanoma cells, Nexturastat A dose-dependently elevated acetyl α-tubulin levels without increasing histone H3 acetylation. Moreover, Nexturastat A potently inhibited the growth of B16 melanoma cells, with the GI50 value of 14.3 μM.

Associated Targets

HDAC4 Tclin Histone deacetylase 4 0 Activities

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 15 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 7 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 0 Activities

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC11 Tclin Histone deacetylase 11 0 Activities

Discover Target: HDAC11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 0 Activities

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 1 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 2 Activities

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 4 Activities

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 0 Activities

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 0 Activities

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
INCHI	InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
InChi Key	JZWXMCPARMXZQV-UHFFFAOYSA-N
Canonical SMILES	CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2
Isomeric SMILES	CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2
PubChem CID	71462653
Molecular Weight	341.4

PubChem CID

CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2213254	Certificate of Analysis	Jun 14, 2022	N349054
H2213255	Certificate of Analysis	Jun 14, 2022	N349054
H2213258	Certificate of Analysis	Jun 14, 2022	N349054
H2213259	Certificate of Analysis	Jun 14, 2022	N349054

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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