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NF-56-EJ40 , CAS No.N612281, Antagonist of succinate receptor

Item Number

N612281

Grouped product items
SKU	Size	Availability	Price	Qty
N612281-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N612281-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of succinate receptor

SUCNR1 Tchem Succinate receptor 1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

INCHI	InChI=1S/C27H29N3O3/c1-29-13-15-30(16-14-29)19-20-9-11-21(12-10-20)22-6-4-7-24(17-22)27(33)28-25-8-3-2-5-23(25)18-26(31)32/h2-12,17H,13-16,18-19H2,1H3,(H,28,33)(H,31,32)
InChi Key	UTWXDNZWMQAUKL-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O
Isomeric SMILES	CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)NC4=CC=CC=C4CC(=O)O
PubChem CID	138811017

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1. Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, Schwärzler C, Junt T, Voshol H, Meingassner JG et al.. (2008) Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.. Nat Immunol, 9 (11): (1261-9). [PMID:18820681] [10.1021/op500134e]
2. Littlewood-Evans A, Sarret S, Apfel V, Loesle P, Dawson J, Zhang J, Muller A, Tigani B, Kneuer R, Patel S et al.. (2016) GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.. J Exp Med, 213 (9): (1655-62). [PMID:27481132] [10.1021/op500134e]
3. Cho EH. (2018) Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis.. Front Endocrinol (Lausanne), 9 (13): (455). [PMID:30186230] [10.1021/op500134e]
4. Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A et al.. (2019) Structural basis of species-selective antagonist binding to the succinate receptor.. Nature, 574 (7779): (581-585). [PMID:31645725] [10.1038/s41586-019-1663-8]

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