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NFPS - ≥98%(HPLC), high purity , CAS No.405225-21-0, GlyT1

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NFPS - ≥98%(HPLC), high purity , CAS No.405225-21-0, GlyT1

Moligand™

≥98%(HPLC)

CAS#: 405225-21-0
Formula: C₂₄H₂₄FNO₃
Molecular Weight: 393.45
PubChem CID: 5311283

Item Number

N288067

Grouped product items
SKU	Size	Availability	Price	Qty
N288067-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$201.90
N288067-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$846.90

Selective non-transportable GlyT1 inhibitor

View related series

GlyT GlyT1 Membrane Transporter/Ion Channel Neuronal Signaling

Basic Description

Synonyms	ALX5407 \| GTPL4620 \| DTXSID30415522 \| GTPL4619 \| N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine \| 2-{[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl](methyl)amino}acetic acid \| BCP17140 \| AKOS024257201 \| ( inverted exclamation markA)-NFPS \| HMS
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPS
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Mechanism of action	GlyT1

Associated Targets(Human)

SLC6A9 Tchem Sodium- and chloride-dependent glycine transporter 1 (2 Activities)

Discover Target: SLC6A9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Slc6a9 Glycine transporter 1 (255 Activities)

Discover Target: Slc6a9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
INCHI	InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)
InChi Key	FDORQEIHOKEJNX-UHFFFAOYSA-N
Canonical SMILES	CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O
Isomeric SMILES	CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O
Alternate CAS	405225-21-0
PubChem CID	5311283
Molecular Weight	393.45

Certificates

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 3.93, Max Conc. mM: 10; Solvent:ethanol, Max Conc. mg/mL: 1.97, Max Conc. mM: 5 with gentle warming

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