NG-Monomethyl-L-arginine Acetate - ≥98%, high purity , Nitric oxide synthase inhibitor, CAS No.53308-83-1, Nitric oxide synthase inhibitor

Item Number

N133898

• Synonyms: L-NMMA acetate | Tilarginine Acetate | 53308-83-1 | L-NMMA | NG-Monomethyl-L-arginine acetate | NG-Methyl-L-arginine acetate salt | Targinine acetate | Tilarginine acetate [USAN] | L-NMMA (acetate) | ANO-1020 | Ng-methylarginine acetate | N-Omega-monomethyl-L-arginine acetate |
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Cell-permeable competitive NOS inhibitor. (K i values are 700 nM, 3.9 µM and 650 nM for eNOS, iNOS and nNOS, respectively).
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: Nitric oxide synthase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2.
An L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)