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NGI 1 - ≥98%(HPLC), high purity , CAS No.790702-57-7
Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
Basic Description Synonyms 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide | NCGC00351072-01 | KSC-367-096-1 | KUC113535N-02 | ZB1632 | HY-117383 | NGI1 | NGI-1 | HMS3081P23 | EX-A2753 | NGI 1 | s8750 | KUC113535N | BN164083 | NGI1; NGI 1; ML414; ML Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proli Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Description：
NGI-1 is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide INCHI InChI=1S/C17H22N4O3S2/c1-12-11-18-17(25-12)19-16(22)14-10-13(26(23,24)20(2)3)6-7-15(14)21-8-4-5-9-21/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,18,19,22) InChi Key QPKGRLIYJGBKJL-UHFFFAOYSA-N Canonical SMILES CC1=CN=C(S1)NC(=O)C2=C(C=CC(=C2)S(=O)(=O)N(C)C)N3CCCC3 Isomeric SMILES CC1=CN=C(S1)NC(=O)C2=C(C=CC(=C2)S(=O)(=O)N(C)C)N3CCCC3 PubChem CID 2519269 Molecular Weight 394.51
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 39.45, Max Conc. mM: 100
Safety and Hazards(GHS) Signal Warning Hazard Statements H303: May be harmful if swallowed
RIDADR NONHforallmodesoftransport
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H2218274