Potent L-type Ca 2+ channel blocker. Alters cytochrome P-450 3A (CYP3A4) expression in rat livers. Elastase inhibitor (IC 50 = 16μM in humans and 18μM in rat). Active in vivo and in vitro.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST, CHANNEL BLOCKER
Mechanism of action
Antagonist of A 3 receptor;Channel blocker of K v1.4
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Nicardipine (YC-93 free base) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure
H2130286