Nicardipine hydrochloride - ≥98%, high purity , CAS No.54527-84-3

Item Number

N129547

Grouped product items
SKU	Size	Availability	Price
N129547-100mg	100mg	In stock	$9.90
N129547-1g	1g	In stock	$58.90
N129547-5g	5g	In stock	$236.90
N129547-25g	25g	In stock	$1,066.90

L-type Ca 2+ channel antagonist

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Basic Description

Synonyms	NICARDIPINE HYDROCHLORIDE\|54527-84-3\|Nicardipine HCl\|Cardene\|Perdipine\|Nicodel\|Loxen\|Perdipina\|YC-93\|Angioglebil\|Bionicard\|Nicardil\|Vasonase\|Dafil\|Nicardipine (Hydrochloride)\|Dagan\|Barizin\|Cardepine\|Dacarel\|Lecibra\|Lecibral\|Lescodil\|Nerdipina\|Nicapress\|Ni
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Nicardipine hydrochloride is the hydrochloride salt preparation of Nicardipine and a potent L-type calcium channel protein inhibitor. Nicardipine is described to alter cytochrome P-450 3A expression through induction of CYP3A. Nicardipine blockade of Ca2+ channels has been correlated to antihypertensive effects. A potent calcium channel protein inhibitor

Names and Identifiers

Pubchem Sid	488183327
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183327
IUPAC Name	5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
INCHI	InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
InChi Key	AIKVCUNQWYTVTO-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl
Isomeric SMILES	CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl
WGK Germany	3
RTECS	US7972100
PubChem CID	41114
Molecular Weight	515.99

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
B1528014	Certificate of Analysis	Jun 15, 2024	N129547
D23211485	Certificate of Analysis	Mar 16, 2023	N129547
D23211489	Certificate of Analysis	Mar 16, 2023	N129547
D23211508	Certificate of Analysis	Mar 16, 2023	N129547
D23211612	Certificate of Analysis	Mar 16, 2023	N129547
D23211626	Certificate of Analysis	Mar 16, 2023	N129547
D23211699	Certificate of Analysis	Mar 16, 2023	N129547
D23211732	Certificate of Analysis	Mar 16, 2023	N129547
D2321699	Certificate of Analysis	Mar 16, 2023	N129547
E1908094	Certificate of Analysis	Jan 18, 2023	N129547

Solubility

Soluble in DMSO (1 mg/ml), water (slightly), methanol (50 mg/ml), chloroform (slightly), and 100% ethanol (slightly).

Sensitivity

Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.
WGK Germany	3
RTECS	US7972100
Merck Index	6495

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Basic Description