Basic Description

Synonyms	nicotinamide \| niacinamide \| 98-92-0 \| 3-Pyridinecarboxamide \| Nicotinic acid amide \| pyridine-3-carboxamide \| vitamin PP \| Aminicotin \| Amixicotyn \| Papulex \| Nicotylamide \| Endobion \| Hansamid \| Nicobion \| Nikotinamid \| Savacotyl \| Benicot \| Dipegyl \| Pelmine \| Nicotinic amide \| Delonin amide
Specifications & Purity	for cell culture, for insect cell culture, ≥99.5%(HPLC)
Biochemical and Physiological Mechanisms	Amide form of vitamin B 3 . Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD + ). Essential for the synthesis of NAD + phosphate (NADP + ). Essential for energy metabolism, normal physiology and dis
Storage Temp	Desiccated
Shipped In	Normal
Grade	for cell culture, for insect cell culture
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Nicotinamide is a NAD+ and NADP+ coenzyme precursor. Nicotinamide is an antiinflammatory agent and a PARP-1 enzyme inhibitor. An NAD+ and NADP+ coenzyme precursor

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

Discover Target: Agtr2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Faah Anandamide amidohydrolase (3907 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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SIR2 NAD-dependent histone deacetylase SIR2 (218 Activities)

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Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania infantum (5912 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Leishmania donovani (89745 Activities)

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Trypanosoma cruzi (99888 Activities)

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Toxoplasma gondii (4585 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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RAW264.7 (28094 Activities)

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panE Ketopantoate reductase (28 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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HST2 NAD-dependent deacetylase HST2 (97 Activities)

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Plasma (328 Activities)

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SIR2RP1 Putative silent information regulator 2 (21 Activities)

Discover Target: SIR2RP1

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cobB NAD-dependent protein deacetylase (1 Activities)

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Glra2 Glycine receptor (1745 Activities)

Discover Target: Glra2

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SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sarm1 NAD(+) hydrolase SARM1 (23 Activities)

Discover Target: Sarm1

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Names and Identifiers

IUPAC Name	pyridine-3-carboxamide
INCHI	InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChi Key	DFPAKSUCGFBDDF-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CN=C1)C(=O)N
Isomeric SMILES	C1=CC(=CN=C1)C(=O)N
WGK Germany	1
RTECS	QS3675000
PubChem CID	936
Molecular Weight	122.12
Beilstein	383619
Reaxy-Rn	383619

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot Number	Certificate Type	Date	Item
B2309199	Certificate of Analysis	Jun 25, 2022	N108087
G2222535	Certificate of Analysis	Jun 25, 2022	N108087
G2222642	Certificate of Analysis	Jun 25, 2022	N108087
H2317080	Certificate of Analysis	Jun 25, 2022	N108087
L2307178	Certificate of Analysis	Jun 25, 2022	N108087

Chemical and Physical Properties

Solubility	Soluble in water (1000 g/l) at 20 °C, ethanol (100 mM), glycerol (1 g/10ml), DMSO (100 mM), methanol, butanol, chloroform, and ether (Slightly).
Sensitivity	light sensitive
Flash Point(°F)	302 °F
Flash Point(°C)	150 °C
Melt Point(°C)	128-131°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	1
RTECS	QS3675000
Reaxy-Rn	383619
Merck Index	6523

FAQs and Articles

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New Uses for Organoids

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Organoids

Guidelines For Common Cell Culture Media

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Biological buffer Cell medium raw materials Cell culture additives Amino acids Vitamins Growth factors Salt Glucose Nucleosides & nucleotides Carbs Cell culture and transfection

Citations of This Product

1. Yucheng Wu, Xueli Wen, Bihe Yuan. (2024) Novel fabrication of flame-retardant melamine sponge for all-weather cleanup of viscous oil spills by Joule heat and photothermal effects. NEW JOURNAL OF CHEMISTRY, 48 (6): (2403-2415). [PMID:]
2. Yangyang Sun, Zhuzhu Tang, Yanjun Li, Yongkang Song, Hualei Wang, Dongzhi Wei, Shengli Yang. (2024) Identification and evolution of non-traditional nitrilase from Spirosoma linguale DSM 74 with high hydration activity. BIOORGANIC CHEMISTRY, 143 (107055). [PMID:38185008]
3. Qi Shen, Shi-Jia Zhang, Bin-Hui Xu, Zhi-Yu Chen, Feng Peng, Neng Xiong, Ya-Ping Xue, Yu-Guo Zheng. (2023) Semirational engineering of Cytophaga hutchinsonii polyphosphate kinase for developing a cost-effective, robust, and efficient adenosine 5′-triphosphate regeneration system. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, [PMID:37902313]
4. Qi Zhang, Mengyuan Xia, Chenxuan Zheng, Yinghong Yang, Junjie Bao, Wenjuan Dai, Xuefeng Mei. (2023) The Cocrystal of Ubiquinol: Improved Stability and Bioavailability. Pharmaceutics, 15 (10): (2499). [PMID:37896258]
5. Sun Yaru, Yu Bin, Liu Yan, Yan Junbo, Xu Zixi, Cheng Bo, Huang Fenglei, Wang Jun. (2023) Bio-inspired surface manipulation of halloysite nanotubes for high-performance flame retardant polylactic acid nanocomposites. Nano Research, (1-12). [PMID:]
6. Wangping Qin, Ruike Zhang, Yan Fu, Jie Chang. (2023) Preparation of a novel bio-based ferric flame retardant for enhancing flame retardancy, mechanical properties, and heat resistance of polylactic acid. JOURNAL OF APPLIED POLYMER SCIENCE, 140 (42): (e54542). [PMID:]
7. Yang Yi, Shi Kaicun, Xu Shufang, Tian Yu, Huang Hong, Cai Xiaoli, Liu Zhimin, Xu Zhigang, Zhang Fengmei, He Pei, Liu Chunbo, Si Xiaoxi. (2023) Dual-Chromatographic Column Tandem Technique for Optimizing Separation and Determination of Vitamin B3. Food Analytical Methods, 16 (9): (1468-1476). [PMID:]
8. Wei Jia, Xin Wang. (2023) 3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner. FOOD CHEMISTRY, 427 (136729). [PMID:37385056]
9. Xiao-Dong Cheng, Zheng Zhang, Yun-Ping Li. (2023) A facile approach to undecylenic acid-functionalized stationary phases for per aqueous liquid chromatography. ANALYTICA CHIMICA ACTA, 1265 (341337). [PMID:37230580]
10. Yani Zheng, Yin Dai, Junqiang Hong, Huizhu Fan, Qing Zhang, Wei Jiang, Wei Xu, Jianwen Fei, Junli Hong. (2023) Magnetic dummy template molecularly imprinted particles functionalized with dendritic nanoclusters for selective enrichment and determination of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in tobacco products. RSC Advances, 13 (20): (13824-13833). [PMID:37152563]
11. Zhiyong Zheng, Yuehua Deng, Weining Xie, Sirui Chen, Xiaoxiao Liang, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang. (2023) Co-Former Screening Method for Multicomponent Crystals Based on Partial Least Squares Regression: A Case Study of Ciprofloxacin. CRYSTAL GROWTH & DESIGN, 23 (5): (3244–3257). [PMID:]
12. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16): (7862-7872). [PMID:]
13. Yang Xintong, Chen Yang, Qiao Ning. (2023) Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal. Brazilian Journal of Pharmaceutical Sciences, 58 (e18768). [PMID:]
14. Hui Zhang, Huahui Zeng, Mengfei Li, Yagang Song, Shuo Tian, Jing Xiong, Lan He, Yang Liu, Xiangxiang Wu. (2022) Novel Ascorbic Acid Co-Crystal Formulations for Improved Stability. MOLECULES, 27 (22): (7998). [PMID:36432100]
15. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu. (2022) N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation. PHARMACOLOGICAL RESEARCH, 185 (106491). [PMID:36244543]
16. Zhongshi Huang, Ning Li, Shiqin Yu, Weiping Zhang, Tianmeng Zhang, Jingwen Zhou. (2022) Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide. ACS Synthetic Biology, 11 (9): (2979–2988). [PMID:35977419]
17. Jiahong Guo, Xiaoyu Ma, Fernando Bouffard, Sophia Yi Zhang. (2022) A Novel multi-fruit acids formula design on molecular basis for skin brightening via a system biology approach. Journal of Cosmetic Dermatology, 21 (11): (6145-6155). [PMID:35713107]
18. Liao Wenli, Rao Zhiwei, Wu Lingling, Chen Yong, Li Cairong. (2022) Cariporide Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation and Apoptosis Partly Through Regulation of Akt/GSK-3β and Sirt1 Signaling Pathway. Frontiers in Pharmacology, 13 [PMID:35747748]
19. Yali Chen, Ling Xia, Xiaohua Xiao, Gongke Li. (2022) Enhanced capillary zone electrophoresis in cyclic olefin copolymer microchannels using the combination of dynamic and static coatings for rapid analysis of carnosine and niacinamide in cosmetics. JOURNAL OF SEPARATION SCIENCE, 45 (12): (2045-2054). [PMID:35324077]
20. Qiurong Luo, Meijun Wan, Jingqiu Zhou, Xuemei Dai, Honglin Yang, Fengjiao Zu, Yunchao Zheng, Lujun Wang. (2022) Preparation and evaluation of a double-hydrophilic interaction stationary phase based on bovine serum albumin and graphene quantum dots modified silica. JOURNAL OF CHROMATOGRAPHY A, 1669 (462933). [PMID:35279558]
21. Chun-Yan Zhang, Wei-Yi Zhang, Guo-Ying Chen, Tong-Qing Chai, Hao Zhang, Yi Xu, Feng-Qing Yang. (2022) Vitamin B3 as a high acid-alkali tolerant peroxidase mimic for colorimetric detection of hydrogen peroxide and glutathione. Arabian Journal of Chemistry, 15 (103823). [PMID:]

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SKU	Size	Availability	Price	Qty
N108087-100g	100g	In stock	$26.90
N108087-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$101.90

Nicotinamide - for cell culture,for insect cell culture,≥99.5%(HPLC), high purity , CAS No.98-92-0